Receptors in the Evolution and Development of the Brain: Matter into Mind - Brossura

Fine, Richard E.

Brossura

ISBN 10: 0128110120 ISBN 13: 9780128110126

Casa editrice: Academic Press, 2019

Riassunto

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer's, Parkinson's, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

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Informazioni sull?autore

Dr. Richard E. Fine received his Bachelor’s and PhD degrees in Biochemistry from University of California at Berkeley and Brandeis University respectively. He then was a postdoctoral fellow in the laboratory of Francis Crick and Sydney Brenner at the Laboratory of Molecular Biology in Cambridge, U.K. During this period he and his colleague, Dennis Bray provided the first evidence for actin in growing neurons. Dr. Fine became an Assistant Professor of Physiology and Biochemistry at Boston University School of Medicine and demonstrated the existence of actin regulatory molecules, tropomyosin and troponin C in growing neurons, and he subsequently became interested in the role of clathrin coated vesicles in endocytic and exocytic processes in neurons and in other tissues. He also isolated and characterized vasopressin receptors, demonstrated for the first time that a large molecular, transferrin, can cross the blood brain barrier. Our lab in collaboration with Dr. Ken Kosik were the first to show that an antisense oligonucleotide can be used in vivo to block the synthesis of a single protein. Using the rabbit retina we were able to show that an antisense nucleotide against the kinesin mRNA can block the critical role of kinesin in the transport of synaptic vesicles, neuropeptide containing vesicles and vesicles destined for the plasma membrane. In recent years Dr. Fine’s laboratory has focused on the role of the amyloid beta peptide in Alzheimer’s disease especially in brain capillary endothelium. Also he has recently focused on the role of a mutant protein VPS35, a component of the retromer in Parkinson’s and Alzheimer’s diseases. During his career he has received over $25,000,000 in grant funding, have served on both NIH and VA review panels and authored or co-authored over 100 research papers.

Dalla quarta di copertina

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands from an evolutionary developmental biology perspective together with a plausible theory for correctly wiring the mammalian brain. It discusses the key functions of receptors in the evolution of the nervous system and the development of the large vertebrate brain. The key role of receptors in wiring the brain correctly is emphasized together with rapid eye movement sleep and apoptosis as mechanisms to destroy miss wired neurons. Finally, the possibility that connectional diseases including Alzheimer’s, Parkinson’s, and ALS result from trophic deficits is discussed together with the possibility of potential stem cell treatments. This book is extremely useful to graduate and students with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and to all readers with a curiosity about how the incredibly complex human brain can build itself.

Dettagli dell'edizione

• Editore: Academic Press
• Data di pubblicazione: 2019
• Lingua: Inglese
• ISBN 10: 0128110120
• ISBN 13: 9780128110126
• Rilegatura: Copertina flessibile
• Numero edizione: 1
• Numero di pagine: 286
• Contatto del produttore: Academic Press; https://shop.elsevier.com/; ; 230 PARK AVENUE, SUITE 800; NY; NY; 10169; U.S.A.
• Persona responsabile: non disponibile