Articoli correlati a Ecogenetics: Genetic predisposition to toxic effects...
Sinossi
Human beings vary in their sensitivity to environmental chemicals. Some people are particularly sensitive to certain chemical compounds and may, therefore, develop adverse effects as a result of exposures that are otherwise considered safe. Considerable variation in susceptibility may be determined by inherited patterns of metabolism. Research in several fields is now beginning to uncover the mechanisms and the significance of such inherited hypersusceptibility to environmental chemicals. This evidence will be of crucial importance for successful protection of all individuals against toxic chemicals. This book, which is based on a WHO consultation, provides an overview of current knowledge on genetic predisposition to chemical toxicity. It reviews the experimental, pharmacological, toxicogenetic and epidemiological evidence and considers the implications for preventative action and future research. The important ethical and legal aspects are covered, as is the importance of genetic factors in the pathogenesis of ischaemic heart disease and major types of cancer. Written and edited by an international team of experts, this book should be a vital reference source for industrial and environmental health officers, health care planners and physicians and researchers in toxicology, pharmacology, genetics, clinical chemistry, epidemiology and occupational health.
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Recensione
Written and edited by an international team of experts, Ecogenetics is a vital reference source...Biomedicine and Pharmacotherapy; The book provides a wealth of data which contain interesting and important information to both the toxicologist and molecular biologist - Chemistry and Industry; ...this is a useful and comprehensive volume...for students or those with broad interests, this volume presents an ideal lead into the diverse areas of ecogenetics... - Animals of Human Biology; For those generally unfamiliar with this field, this is a useful and comprehensive volume - Annals of Human Biology
Contenuti
One Significance for Public Health and Research.- 1 Report on a WHO consultation.- Two Perspectives of Genetic Predisposition.- 2 Genetic predisposition to occupationally-related diseases: current status and future directions.- 3 Genetic predisposition to environmental toxic agents: detection by distribution of ecogenetic markers.- 4 Genetic predisposition to common diseases.- Three Experimental Evidence.- 5 Evidence in laboratory animal studies of genetic predisposition to effects of toxic chemicals.- 6 Animal models for studies of genetic predisposition to adverse effects of chemical exposure.- 7 Sex-related differences in genetic susceptibility to toxic chemicals.- Four Pharmacogenetic Evidence.- 8 Lessons from pharmocogenetics.- 9 Human variability in alcohol and aldehyde metabolism: vulnerability to toxic effects.- 10 Detection of unsuspected non-fava-bean-sensitive G-6-PD deficiency in semiconductor fabrication workers in Israel.- Five Toxicogenetic Evidence.- 11 Prevalence of important polymorphisms in Poland.- 12 Phenotypes of human serum esterases reacting with organophosphates, carbamates and other esters.- 13 Predisposition in exposure to carbon disulfide.- 14 Genetic susceptibility to DNA-methylating agents.- 15 Interindividual variation in the level of DNA and protein adducts in humans.- Six Ethical and Regulatory Aspects.- 16 Ethical aspects of genetic predisposition to disease.- 17 Health policy, ethics and human values.- 18 Significance of hypersusceptibility for risk assessment.- 19 Examples of regulatory practices to protect hypersusceptible groups of workers.- Appendix: List of Participants.
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Ecogenetics: Genetic predisposition to toxic effects of chemicals
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Ecogenetics
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Springer Netherlands Jun 1991, 1991
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Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Protection of human health by prevention of environmental hazards has become a major concern in all European countries. This concern is reflected in the regional strategy of Health for All by the Year 2000, as developed in 1984, and in the 1989 European Charter on Environment and Health. However, despite considerable progress, most efforts are related to single sources of exposure and to a small number of 'priority' chemicals. In protecting the population against chemical hazards, attention must also be paid to the fact that subgroups are particularly susceptible to the adverse effects of certain chemicals. This hypersusceptibility may be genetically determined. Such individual predisposition to toxic effects must be taken into account in the efforts to prevent adverse effects of environmental exposures to toxic chemicals. To help address these problems the Regional Office, in co-operation with the Institute of Human Genetics and Anthropology of the Univer sity of Dusseldorf and with financial support from the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety of the Federal Republic of Germany, organized a consultation in Krefeld in October 1989. The meeting was attended by 17 experts from 12 coun tries, three representatives of the host government, two representatives of other organizations and five staff members from the WHO Regional Office for Europe and WHO Headquarters. The list of participants is included as an appendix to the present volume. 308 pp. Englisch. Codice articolo 9780412392900
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Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Protection of human health by prevention of environmental hazards has become a major concern in all European countries. This concern is reflected in the regional strategy of Health for All by the Year 2000, as developed in 1984, and in the 1989 European Cha. Codice articolo 5914577
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Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Protection of human health by prevention of environmental hazards has become a major concern in all European countries. This concern is reflected in the regional strategy of Health for All by the Year 2000, as developed in 1984, and in the 1989 European Charter on Environment and Health. However, despite considerable progress, most efforts are related to single sources of exposure and to a small number of 'priority' chemicals. In protecting the population against chemical hazards, attention must also be paid to the fact that subgroups are particularly susceptible to the adverse effects of certain chemicals. This hypersusceptibility may be genetically determined. Such individual predisposition to toxic effects must be taken into account in the efforts to prevent adverse effects of environmental exposures to toxic chemicals. To help address these problems the Regional Office, in co-operation with the Institute of Human Genetics and Anthropology of the Univer sity of Dusseldorf and with financial support from the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety of the Federal Republic of Germany, organized a consultation in Krefeld in October 1989. The meeting was attended by 17 experts from 12 coun tries, three representatives of the host government, two representatives of other organizations and five staff members from the WHO Regional Office for Europe and WHO Headquarters. The list of participants is included as an appendix to the present volume. Codice articolo 9780412392900
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Condizione: New. A presentation of the proceedings of a WHO meeting held in Krefeld in the Federal Republic of Germany, 17-20 October 1989. The essays explore the effect of toxic chemicals on human genetics, regarding this as one factor in an individual's health response to environmental chemicals. Editor(s): Grandjean, Philippe. Num Pages: 288 pages, biography. BIC Classification: PSBT; RN. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 234 x 156 x 19. Weight in Grams: 609. . 1991. Hardback. . . . . Codice articolo V9780412392900
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Ecogenetics | Genetic predisposition to toxic effects of chemicals
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Buch. Condizione: Neu. Ecogenetics | Genetic predisposition to toxic effects of chemicals | P. Grandjean | Buch | Einband - fest (Hardcover) | Englisch | 1991 | Springer Netherland | EAN 9780412392900 | Verantwortliche Person für die EU: Springer Netherlands, Haberstr. 7, 69126 Heidelberg, buchhandel-buch[at]springer[dot]com | Anbieter: preigu Print on Demand. Codice articolo 101980370
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Ecogenetics
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Springer Netherlands, Springer Netherlands Jun 1991, 1991
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Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Protection of human health by prevention of environmental hazards has become a major concern in all European countries. This concern is reflected in the regional strategy of Health for All by the Year 2000, as developed in 1984, and in the 1989 European Charter on Environment and Health. However, despite considerable progress, most efforts are related to single sources of exposure and to a small number of 'priority' chemicals. In protecting the population against chemical hazards, attention must also be paid to the fact that subgroups are particularly susceptible to the adverse effects of certain chemicals. This hypersusceptibility may be genetically determined. Such individual predisposition to toxic effects must be taken into account in the efforts to prevent adverse effects of environmental exposures to toxic chemicals. To help address these problems the Regional Office, in co-operation with the Institute of Human Genetics and Anthropology of the Univer sity of Dusseldorf and with financial support from the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety of the Federal Republic of Germany, organized a consultation in Krefeld in October 1989. The meeting was attended by 17 experts from 12 coun tries, three representatives of the host government, two representatives of other organizations and five staff members from the WHO Regional Office for Europe and WHO Headquarters. The list of participants is included as an appendix to the present volume.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch. Codice articolo 9780412392900
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