Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis - Brossura

 
9781461350255: Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
Brossura
ISBN 10: 1461350255 ISBN 13: 9781461350255
Casa editrice: Springer, 2012

Sinossi

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

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Contenuti

Contributors. Preface. 1. Introduction; G.G. Harrigan, R. Goodacre. 2. Metabolome and Proteome Profiling for Microbial Characterization; S. Vaidyanathan, R. Goodacre. 3. Can 1H NMR Derived Metabolic Profiles Contribute to Proteomic Analyses? J.L. Griffin, E. Sang. 4. Application of Metabonomics in the Pharmaceutical Industry; A.P. Breau, G.H. Cantor. 5. Metabolic Profiling in Tumors by in Vivo and in Vitro NMR Spectroscopy; Yeun-Li Chung, M. Stubbs, J. Griffiths. 6. Raman Spectroscopy for Whole Organism and Tissue Profiling; S. Clarke, R. Goodacre. 7. Metabolic Fingerprinting with Fourier Transform Infrared Spectroscopy; D.I. Ellis, G.G. Harrigan, R. Goodacre. 8. Metabolomic Analysis with with Fourier Transform Ion Cyclotron Resonance Mass Spectroscopy; D. Goodenowe. 9. Stable Isotope-Based Dynamic Metabolic Profiling in Disease and Health; L.G. Boros, M. Cascante, W.-N.P. Lee. 10. The role of Metabolomics in Systems Biology; J.van der Greef, E. Davidov, E. Verheij, J. Vogels, R.van der Heijden, A.S. Adourian, M. Oresic, E.W. Marple, S. Naylor. 11. Use of Metabolomics to Discover Metabolic Patterns Associated with Human Diseases; O. Fiehn, J. Spranger. 12. Bioactive Lipids in Reproductive Diseases; J. Chaudhary, T. Compton, J.A. Parrott. 13. Evolutionary Computation for the Interpretation of Metabolomic Data; R. Goodacre, D.B. Kell. 14. Dynamic Profiling and Canonical Modeling; E.O. Voit, J. Almeida. 15. Databases, Data Modeling and Schemas; N. Hardy, H. Fuell. 16. Databases and Visualization for Metabolomics; X. Jing Lee, O. Brazhnik, A. Kamal, D. Guo, C. Lee, S. Hoops, P. Mendes. 17. The Human Metabolome. C.W.W. Beecher. Index.

Product Description

Book by None

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Editore
Springer
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
1461350255
ISBN 13 
9781461350255
Rilegatura
Copertina flessibile
Numero di pagine
352
Redattore
Harrigan George G., Goodacre Royston
Contatto del produttore
non disponibile
Persona responsabile
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Germania

Altre edizioni note dello stesso titolo

9781402073700: Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

Edizione in evidenza

ISBN 10:  1402073704 ISBN 13:  9781402073700
Casa editrice: Kluwer Academic Pub, 2003
Rilegato