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Validation Of Bioanalytical Methods Of Drugs: Emphasis of Drug Protein Binding on Method Validation - Brossura
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In this book a variety of techniques for the extraction of drugs from the plasma matrix have been investigated, the data was subjected to different statistical evaluation procedures, to properly evaluate the measured analytical outcomes. After evaluating the concentration–time profiles of pooled samples, previously harvested from dosed human volunteers, the effect of different extraction procedures on the calculated pharmacokinetic parameters was compared. Two types of drugs, classified as Non-Insulin-Dependent Diabetes Mellitus (NIDDM) active ingredients were selected in this study. Glibenclamide was chosen to represent a highly protein bound drug, whereas Metformin was chosen to represent a low protein bound drug. The primary bioanalytical methods validation parameters such as recovery, selectivity, specificity, sensitivity, limit of quantitation and limit of detection, in addition to uncertainty in the analytical measurement have been extensively reviewed. Rigorous approaches using different statistical weights for evaluating calibration data were also derived for each drug using various experimental conditions.
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L'autore
Dr. Adi Said obtained his Ph.D. degree in analytical chemistry from University of Jordan. He has 18 publications and studies. He held several posts at Royal Scientific Society since 1994 the latest is a Assistant Researcher. He has over twenty three years experience in both classical and instrumental analytical/bio-analytical chemistry.
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Validation Of Bioanalytical Methods Of Drugs
Editore:
LAP LAMBERT Academic Publishing Sep 2012, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this book a variety of techniques for the extraction of drugs from the plasma matrix have been investigated, the data was subjected to different statistical evaluation procedures, to properly evaluate the measured analytical outcomes. After evaluating the concentration time profiles of pooled samples, previously harvested from dosed human volunteers, the effect of different extraction procedures on the calculated pharmacokinetic parameters was compared. Two types of drugs, classified as Non-Insulin-Dependent Diabetes Mellitus (NIDDM) active ingredients were selected in this study. Glibenclamide was chosen to represent a highly protein bound drug, whereas Metformin was chosen to represent a low protein bound drug. The primary bioanalytical methods validation parameters such as recovery, selectivity, specificity, sensitivity, limit of quantitation and limit of detection, in addition to uncertainty in the analytical measurement have been extensively reviewed. Rigorous approaches using different statistical weights for evaluating calibration data were also derived for each drug using various experimental conditions. 308 pp. Englisch. Codice articolo 9783659237843
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Validation Of Bioanalytical Methods Of Drugs
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Said Adi J.Dr. Adi Said obtained his Ph.D. degree in analytical chemistry from University of Jordan. He has 18 publications and studies. He held several posts at Royal Scientific Society since 1994 the latest is a Assistant Research. Codice articolo 5142080
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Validation Of Bioanalytical Methods Of Drugs : Emphasis of Drug Protein Binding on Method Validation
Editore:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Da: AHA-BUCH GmbH, Einbeck, Germania
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - In this book a variety of techniques for the extraction of drugs from the plasma matrix have been investigated, the data was subjected to different statistical evaluation procedures, to properly evaluate the measured analytical outcomes. After evaluating the concentration time profiles of pooled samples, previously harvested from dosed human volunteers, the effect of different extraction procedures on the calculated pharmacokinetic parameters was compared. Two types of drugs, classified as Non-Insulin-Dependent Diabetes Mellitus (NIDDM) active ingredients were selected in this study. Glibenclamide was chosen to represent a highly protein bound drug, whereas Metformin was chosen to represent a low protein bound drug. The primary bioanalytical methods validation parameters such as recovery, selectivity, specificity, sensitivity, limit of quantitation and limit of detection, in addition to uncertainty in the analytical measurement have been extensively reviewed. Rigorous approaches using different statistical weights for evaluating calibration data were also derived for each drug using various experimental conditions. Codice articolo 9783659237843
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Validation Of Bioanalytical Methods Of Drugs: Emphasis of Drug Protein Binding on Method Validation
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Validation Of Bioanalytical Methods Of Drugs: Emphasis of Drug Protein Binding on Method Validation
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ISBN 10: 3659237841
ISBN 13: 9783659237843
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Validation Of Bioanalytical Methods Of Drugs: Emphasis of Drug Protein Binding on Method Validation
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Validation Of Bioanalytical Methods Of Drugs: Emphasis Of Drug Protein Binding On Method Validation
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Lap Lambert Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Paperback. Condizione: Brand New. 308 pages. 8.66x5.91x0.70 inches. In Stock. Codice articolo 3659237841
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Validation Of Bioanalytical Methods Of Drugs
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LAP LAMBERT Academic Publishing Sep 2012, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this book a variety of techniques for the extraction of drugs from the plasma matrix have been investigated, the data was subjected to different statistical evaluation procedures, to properly evaluate the measured analytical outcomes. After evaluating the concentration-time profiles of pooled samples, previously harvested from dosed human volunteers, the effect of different extraction procedures on the calculated pharmacokinetic parameters was compared. Two types of drugs, classified as Non-Insulin-Dependent Diabetes Mellitus (NIDDM) active ingredients were selected in this study. Glibenclamide was chosen to represent a highly protein bound drug, whereas Metformin was chosen to represent a low protein bound drug. The primary bioanalytical methods validation parameters such as recovery, selectivity, specificity, sensitivity, limit of quantitation and limit of detection, in addition to uncertainty in the analytical measurement have been extensively reviewed. Rigorous approaches using different statistical weights for evaluating calibration data were also derived for each drug using various experimental conditions. 308 pp. Englisch. Codice articolo 9783659237843
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Validation Of Bioanalytical Methods Of Drugs | Emphasis of Drug Protein Binding on Method Validation
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659237841
ISBN 13: 9783659237843
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Taschenbuch. Condizione: Neu. Validation Of Bioanalytical Methods Of Drugs | Emphasis of Drug Protein Binding on Method Validation | Adi J. Said | Taschenbuch | 308 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783659237843 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Codice articolo 106200284
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