Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin: Gastro - retentive floating matrix tablets - Brossura
Sinossi
The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.
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L'autore
Mr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AndraPradesh, India. He completed His B.Pharm and M.Pharm from Kakatiya University. He received “Research Excellence awrad” in 63rd IPC.
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Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin
Editore:
LAP LAMBERT Academic Publishing Sep 2012, 2012
ISBN 10: 3659238147
ISBN 13: 9783659238147
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up. 64 pp. Englisch. Codice articolo 9783659238147
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Formulation & Evaluation Of Floating Matrix Tablets Of Levofloxacin: Gastro - Retentive Floating Matrix Tablets
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Lap Lambert Academic Publishing, 2012
ISBN 10: 3659238147
ISBN 13: 9783659238147
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Paperback. Condizione: Brand New. 64 pages. 8.82x6.18x0.39 inches. In Stock. Codice articolo zk3659238147
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Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659238147
ISBN 13: 9783659238147
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dudhipala NarendarMr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A. Codice articolo 5142104
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Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin
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LAP LAMBERT Academic Publishing Sep 2012, 2012
ISBN 10: 3659238147
ISBN 13: 9783659238147
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 64 pp. Englisch. Codice articolo 9783659238147
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Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin : Gastro - retentive floating matrix tablets
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659238147
ISBN 13: 9783659238147
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up. Codice articolo 9783659238147
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Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin | Gastro - retentive floating matrix tablets
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LAP LAMBERT Academic Publishing, 2013
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ISBN 13: 9783659238147
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Taschenbuch. Condizione: Neu. Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin | Gastro - retentive floating matrix tablets | Narendar Dudhipala (u. a.) | Taschenbuch | 64 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659238147 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Codice articolo 106244568
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