Articoli correlati a Genetic and Cellular Studies of the podocyte in FSGS:...
Genetic and Cellular Studies of the podocyte in FSGS: FSGS is an abbreviation for a kidney disease named focal segmental glomerulosclersis - Brossura
Sinossi
The podocyte forms the outer layer of the filtration barrier to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. I performed a genetic analysis of both familial and sporadic FSGS patients, and I investigated the role of the actin cytoskeleton in podocytes. We identified a new FSGS susceptibility gene, ARHGAP24, and showed that it was mutated in a family with FSGS. My work suggested that this balance between Rac and Rho might be important in FSGS. Using an inducible transgenic mouse model and multi-photon intravital microscopy, we validated that high activity of Rac1, is responsible for podocyte foot process effacement, increased membrane dynamics, and podocyte shedding into the urine, which could lead to proteinuria and FSGS. By sequencing a large cohort of sporadic FSGS patients, and using a novel podocyte-specific indicible RNAi mouse model that I developed, we validated four novel genes that could contribute to FSGS. Some of these genes function as regulators of the actin cytoskeleton. Our genetic study reinforces the role of actin cytoskeletal regulation in the pathogenesis of FSGS.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
Compra nuovo
Visualizza questo articolo
EUR 50,66
EUR 9,70 per la spedizione da Germania a Italia
Destinazione, tempi e costiRisultati della ricerca per Genetic and Cellular Studies of the podocyte in FSGS:...
Immagini fornite dal venditore
Genetic and Cellular Studies of the podocyte in FSGS
Editore:
LAP LAMBERT Academic Publishing, 2015
ISBN 10: 3659751502
ISBN 13: 9783659751509
Nuovo
Brossura
Da: moluna, Greven, Germania
Valutazione del venditore 5 su 5 stelle
Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Yu HaiyangHaiyang Yu,A postdoctoral researcher mentored by Dr. Don W. Cleveland in Ludwig Institute for Cancer Research (San Diego Branch)when this work is published. He earned a bachelor s degree from Nankai Univeristy, in Tianjin, . Codice articolo 158962127
Quantità: Più di 20 disponibili
Immagini fornite dal venditore
Genetic and Cellular Studies of the podocyte in FSGS
Editore:
LAP LAMBERT Academic Publishing Jul 2015, 2015
ISBN 10: 3659751502
ISBN 13: 9783659751509
Nuovo
Taschenbuch
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
Valutazione del venditore 5 su 5 stelle
Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The podocyte forms the outer layer of the filtration barrier to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. I performed a genetic analysis of both familial and sporadic FSGS patients, and I investigated the role of the actin cytoskeleton in podocytes. We identified a new FSGS susceptibility gene, ARHGAP24, and showed that it was mutated in a family with FSGS. My work suggested that this balance between Rac and Rho might be important in FSGS. Using an inducible transgenic mouse model and multi-photon intravital microscopy, we validated that high activity of Rac1, is responsible for podocyte foot process effacement, increased membrane dynamics, and podocyte shedding into the urine, which could lead to proteinuria and FSGS. By sequencing a large cohort of sporadic FSGS patients, and using a novel podocyte-specific indicible RNAi mouse model that I developed, we validated four novel genes that could contribute to FSGS. Some of these genes function as regulators of the actin cytoskeleton. Our genetic study reinforces the role of actin cytoskeletal regulation in the pathogenesis of FSGS. 148 pp. Englisch. Codice articolo 9783659751509
Quantità: 2 disponibili
Immagini fornite dal venditore
Genetic and Cellular Studies of the podocyte in FSGS : FSGS is an abbreviation for a kidney disease named focal segmental glomerulosclersis
Editore:
LAP LAMBERT Academic Publishing, 2015
ISBN 10: 3659751502
ISBN 13: 9783659751509
Nuovo
Taschenbuch
Da: AHA-BUCH GmbH, Einbeck, Germania
Valutazione del venditore 5 su 5 stelle
Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The podocyte forms the outer layer of the filtration barrier to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. I performed a genetic analysis of both familial and sporadic FSGS patients, and I investigated the role of the actin cytoskeleton in podocytes. We identified a new FSGS susceptibility gene, ARHGAP24, and showed that it was mutated in a family with FSGS. My work suggested that this balance between Rac and Rho might be important in FSGS. Using an inducible transgenic mouse model and multi-photon intravital microscopy, we validated that high activity of Rac1, is responsible for podocyte foot process effacement, increased membrane dynamics, and podocyte shedding into the urine, which could lead to proteinuria and FSGS. By sequencing a large cohort of sporadic FSGS patients, and using a novel podocyte-specific indicible RNAi mouse model that I developed, we validated four novel genes that could contribute to FSGS. Some of these genes function as regulators of the actin cytoskeleton. Our genetic study reinforces the role of actin cytoskeletal regulation in the pathogenesis of FSGS. Codice articolo 9783659751509
Quantità: 1 disponibili
Immagini fornite dal venditore
Genetic and Cellular Studies of the podocyte in FSGS
Editore:
LAP LAMBERT Academic Publishing Jul 2015, 2015
ISBN 10: 3659751502
ISBN 13: 9783659751509
Nuovo
Taschenbuch
Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
Valutazione del venditore 5 su 5 stelle
Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The podocyte forms the outer layer of the filtration barrier to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. I performed a genetic analysis of both familial and sporadic FSGS patients, and I investigated the role of the actin cytoskeleton in podocytes. We identified a new FSGS susceptibility gene, ARHGAP24, and showed that it was mutated in a family with FSGS. My work suggested that this balance between Rac and Rho might be important in FSGS. Using an inducible transgenic mouse model and multi-photon intravital microscopy, we validated that high activity of Rac1, is responsible for podocyte foot process effacement, increased membrane dynamics, and podocyte shedding into the urine, which could lead to proteinuria and FSGS. By sequencing a large cohort of sporadic FSGS patients, and using a novel podocyte-specific indicible RNAi mouse model that I developed, we validated four novel genes that could contribute to FSGS. Some of these genes function as regulators of the actin cytoskeleton. Our genetic study reinforces the role of actin cytoskeletal regulation in the pathogenesis of FSGS.Books on Demand GmbH, Überseering 33, 22297 Hamburg 148 pp. Englisch. Codice articolo 9783659751509
Quantità: 1 disponibili
Foto dell'editore
Genetic and Cellular Studies of the podocyte in FSGS
Editore:
LAP Lambert Academic Publishing, 2015
ISBN 10: 3659751502
ISBN 13: 9783659751509
Antico o usato
paperback
Da: Mispah books, Redhill, SURRE, Regno Unito
Valutazione del venditore 4 su 5 stelle
paperback. Condizione: Like New. Like New. book. Codice articolo ERICA80036597515026
Quantità: 1 disponibili