Simultaneous estimation of Atorvastatin, Clopidogril & Aspirin: Simultaneous estimation of Atorvastatin, Clopidogril and Aspirin by using UV-VIZ Spectroscopy - Brossura

Singh, Sunil

Brossura

ISBN 10: 3659942812 ISBN 13: 9783659942815

Casa editrice: LAP LAMBERT Academic Publishing, 2016

Riassunto

Atorvastatin [R-(R*,R*)]-2-(4-fluorophenyl)-ß, -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrole 1-heptanoic acid an Anti-hyperlipidemia and Clopidogrel (2-Chloro phenyl, 6-7 dihydro4H thieno [3,2-c]pyridine-5-yl)acetic acid is an Anti-platelet drug and Aspirin (2-Acetoxy benzoic acid) an NSAIDs. This paper presents two methods i.e. first derivative spectrophotometery and multicomponent spectrophotometery for simultaneous estimation of these three drugs combination in pharmaceutical formulations. The first derivative amplitudes at 276, 226 and 222 nm were utilized for simultaneous estimations. The multicomponent amplitudes at 247, 220 and 235 nm were utilizatied. Proper selection of wavelength for estimations of one drug by other in derivative spectra and multicomponent lead to successful development of methods for simultaneous estimation. The results of analysis were validated statistically that included parameters such as precision, LOD, LOQ, recovery and robustness. Both methods were simple, economical, accurate, reproducible and precise.

Dettagli dell?edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2016
• Lingua: Inglese
• ISBN 10: 3659942812
• ISBN 13: 9783659942815
• Rilegatura: Copertina flessibile
• Numero di pagine: 88
• Contatto del produttore: non disponibile
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