Modulation of protein-protein interactions: The role of short peptides in modulating protein-protein interactions in-vivo - Brossura

Dar, Altaf

Brossura

ISBN 10: 3843361789 ISBN 13: 9783843361781

Casa editrice: LAP LAMBERT Academic Publishing, 2010

Riassunto

Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.

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L'autore

Altaf A Dar is currently working on identifying biomarkers involved in melanoma progression and metastasis at CPMC, San Francisco, CA. Previously Dr. Dar worked on gastric cancer at Vanderbilt University, Nashville, TN. Dr. Dar earned his PhD from Friedrich Schiller University, Jena Germany, where he worked on protein-protein interactions.

Dettagli dell'edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2010
• Lingua: Inglese
• ISBN 10: 3843361789
• ISBN 13: 9783843361781
• Rilegatura: Copertina flessibile
• Numero di pagine: 96
• Contatto del produttore: non disponibile
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