Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in western nations. Endothelial dysfunction precedes atherosclerosis and subsequent CVD. Endothelial dysfunction can be monitored be assessing a phenomenon known as flow-mediated dilation (FMD)- the regulation of vessel diameter in response to changes in shear rate (a product of blood velocity and vessel diameter). A popular non-invasive test of FMD has been developed, and has been noted for its capacity to predict CVD. However, this test would be more sensitive and reliable if the FMD response (usually expressed as change in diameter) is normalized to the shear stimulus. This book presents a literature review on the relationship between blood velocity/shear rate and FMD, as well as the findings from two studies. The purpose of study one was to determine the importance of velocity acceleration to FMD. The second study assessed whether peak- and time integrated-shear rates independently predict FMD. Collectively these studies suggest that: 1) The shear stimuli is not a linear function of mean blood velocity. And, 2) Peak- and time integrated-shear rates independently predict FMD.
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Dr. Stoner completed his M.A and Ph.D in Exercise Physiology at The University of Georgia (UGA). He is currently the Director of Academic Affairs for American Universities International Programs. Dr. McCully completed his Ph.D at the University of Michigan. He is a Professor at UGA where he directs the Exercise Vascular Biology Laboratory.
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in western nations. Endothelial dysfunction precedes atherosclerosis and subsequent CVD. Endothelial dysfunction can be monitored be assessing a phenomenon known as flow-mediated dilation (FMD)- the regulation of vessel diameter in response to changes in shear rate (a product of blood velocity and vessel diameter). A popular non-invasive test of FMD has been developed, and has been noted for its capacity to predict CVD. However, this test would be more sensitive and reliable if the FMD response (usually expressed as change in diameter) is normalized to the shear stimulus. This book presents a literature review on the relationship between blood velocity/shear rate and FMD, as well as the findings from two studies. The purpose of study one was to determine the importance of velocity acceleration to FMD. The second study assessed whether peak- and time integrated-shear rates independently predict FMD. Collectively these studies suggest that: 1) The shear stimuli is not a linear function of mean blood velocity. And, 2) Peak- and time integrated-shear rates independently predict FMD. 132 pp. Englisch. Codice articolo 9783843393812
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in western nations. Endothelial dysfunction precedes atherosclerosis and subsequent CVD. Endothelial dysfunction can be monitored be assessing a phenomenon known as flow-mediated dilation (FMD)- the regulation of vessel diameter in response to changes in shear rate (a product of blood velocity and vessel diameter). A popular non-invasive test of FMD has been developed, and has been noted for its capacity to predict CVD. However, this test would be more sensitive and reliable if the FMD response (usually expressed as change in diameter) is normalized to the shear stimulus. This book presents a literature review on the relationship between blood velocity/shear rate and FMD, as well as the findings from two studies. The purpose of study one was to determine the importance of velocity acceleration to FMD. The second study assessed whether peak- and time integrated-shear rates independently predict FMD. Collectively these studies suggest that: 1) The shear stimuli is not a linear function of mean blood velocity. And, 2) Peak- and time integrated-shear rates independently predict FMD. Codice articolo 9783843393812
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Taschenbuch. Condizione: Neu. Neuware -Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in western nations. Endothelial dysfunction precedes atherosclerosis and subsequent CVD. Endothelial dysfunction can be monitored be assessing a phenomenon known as flow-mediated dilation (FMD)- the regulation of vessel diameter in response to changes in shear rate (a product of blood velocity and vessel diameter). A popular non-invasive test of FMD has been developed, and has been noted for its capacity to predict CVD. However, this test would be more sensitive and reliable if the FMD response (usually expressed as change in diameter) is normalized to the shear stimulus. This book presents a literature review on the relationship between blood velocity/shear rate and FMD, as well as the findings from two studies. The purpose of study one was to determine the importance of velocity acceleration to FMD. The second study assessed whether peak- and time integrated-shear rates independently predict FMD. Collectively these studies suggest that: 1) The shear stimuli is not a linear function of mean blood velocity. And, 2) Peak- and time integrated-shear rates independently predict FMD.Books on Demand GmbH, Überseering 33, 22297 Hamburg 132 pp. Englisch. Codice articolo 9783843393812
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