Understanding Tertiary Interactions In Protein Structures: Use of Computational Methods and Techniques - Brossura

Bawa, Tejdeep Singh

 
9783843394031: Understanding Tertiary Interactions In Protein Structures: Use of Computational Methods and Techniques
Brossura
ISBN 10: 3843394032 ISBN 13: 9783843394031
Casa editrice: LAP LAMBERT Academic Publishing, 2011

Sinossi

Three-dimensional structures of proteins are the support of their biological functions.Their folds are stabilized by contacts between residues.Inner protein contacts are generally described through direct atomic contacts,while contact prediction methods mainly used inter-C? distances. During the process of protein folding,the amino acid residues along the polypeptide chain interact with each other in a cooperative manner to form a stable native structure.The knowledge about inter-residue interactions in protein structures is helpful to understand the mechanism of protein folding and stability.It provides valuable insights for understanding protein folding and de novo protein design.I analyzed protein contacts on a high quality non-redundant pdbs drawn from protein databank using various criteria. I have computed the average number of contacts depending on the distance threshold to define a contact.Preferential contacts between types of amino acids have been highlighted. Detailed analysis have been done concerning the proximity of contacts in the sequence,the size of the proteins and fold classes.The strongest differences have been extracted,highlighting important residues.

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L'autore

Tejdeep is currently reading for a MA degree in Biomedical Informatics at Columbia University,completed his B.Tech in Computer Science and Engineering from GGSIP University,Delhi. Tejdeep has worked as a Research Asst. at SCFBio,IIT Delhi,and currently works at the Honig Lab,Center for Computational Biology and Bioinformatics at Columbia University

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2011
Lingua
Inglese
ISBN 10 
3843394032
ISBN 13 
9783843394031
Rilegatura
Copertina flessibile
Numero di pagine
64
Contatto del produttore
non disponibile
Persona responsabile
KreGa Onlinehandel GmbH
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