Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals: Modulation of Human Immunodeficiency Virus Type-1 Co-Receptors Expression on the Cell Surface by Anti-Viral Compounds - Brossura
Sinossi
It is the cell surface molecule receptor CD4 and the two chemokine co-receptors CCR5 and CXCR4 that allow the Human Immunodeficiency Virus (HIV) to enter and infect target cells; these are the direct or indirect targets of anti-retroviral drugs (ARV) currently being tested in clinical trials. No characterisation of the potential effect of these drugs on the level of expression of the receptor and/or co-receptors on the cell surface has, as of yet been performed. This is despite the existence of heterologous modulation of at least CCR5 by compounds which are structurally similar to some ARV drugs. We investigated whether candidate microbicides could modulate the expression of CD4, CCR5 and/or CXCR4 on the cell surface membrane of various cell types. Cell lines expressing different or unknown levels of co-receptors were incubated with entry inhibitors, reverse transcriptase inhibitors and protease inhibitors in a time course mode before assessment by flow cytometry.
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L'autore
Daniel Yaw Adu BSc(Hons),MRes born in London in 1987 entered the Masters of Research program at St George’s University of London to pursue his medical interests. This thesis was based on his Masters project. This thesis was typed by the author. Contact: daniel.adu@hotmail.co.uk
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Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals
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LAP LAMBERT Academic Publishing Jun 2011, 2011
ISBN 10: 3844334246
ISBN 13: 9783844334241
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It is the cell surface molecule receptor CD4 and the two chemokine co-receptors CCR5 and CXCR4 that allow the Human Immunodeficiency Virus (HIV) to enter and infect target cells; these are the direct or indirect targets of anti-retroviral drugs (ARV) currently being tested in clinical trials. No characterisation of the potential effect of these drugs on the level of expression of the receptor and/or co-receptors on the cell surface has, as of yet been performed. This is despite the existence of heterologous modulation of at least CCR5 by compounds which are structurally similar to some ARV drugs. We investigated whether candidate microbicides could modulate the expression of CD4, CCR5 and/or CXCR4 on the cell surface membrane of various cell types. Cell lines expressing different or unknown levels of co-receptors were incubated with entry inhibitors, reverse transcriptase inhibitors and protease inhibitors in a time course mode before assessment by flow cytometry. 92 pp. Englisch. Codice articolo 9783844334241
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Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals
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LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844334246
ISBN 13: 9783844334241
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Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals
Editore:
LAP LAMBERT Academic Publishing Jun 2011, 2011
ISBN 10: 3844334246
ISBN 13: 9783844334241
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It is the cell surface molecule receptor CD4 and the two chemokine co-receptors CCR5 and CXCR4 that allow the Human Immunodeficiency Virus (HIV) to enter and infect target cells; these are the direct or indirect targets of anti-retroviral drugs (ARV) currently being tested in clinical trials. No characterisation of the potential effect of these drugs on the level of expression of the receptor and/or co-receptors on the cell surface has, as of yet been performed. This is despite the existence of heterologous modulation of at least CCR5 by compounds which are structurally similar to some ARV drugs. We investigated whether candidate microbicides could modulate the expression of CD4, CCR5 and/or CXCR4 on the cell surface membrane of various cell types. Cell lines expressing different or unknown levels of co-receptors were incubated with entry inhibitors, reverse transcriptase inhibitors and protease inhibitors in a time course mode before assessment by flow cytometry.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 92 pp. Englisch. Codice articolo 9783844334241
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Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals : Modulation of Human Immunodeficiency Virus Type-1 Co-Receptors Expression on the Cell Surface by Anti-Viral Compounds
Editore:
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844334246
ISBN 13: 9783844334241
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - It is the cell surface molecule receptor CD4 and the two chemokine co-receptors CCR5 and CXCR4 that allow the Human Immunodeficiency Virus (HIV) to enter and infect target cells; these are the direct or indirect targets of anti-retroviral drugs (ARV) currently being tested in clinical trials. No characterisation of the potential effect of these drugs on the level of expression of the receptor and/or co-receptors on the cell surface has, as of yet been performed. This is despite the existence of heterologous modulation of at least CCR5 by compounds which are structurally similar to some ARV drugs. We investigated whether candidate microbicides could modulate the expression of CD4, CCR5 and/or CXCR4 on the cell surface membrane of various cell types. Cell lines expressing different or unknown levels of co-receptors were incubated with entry inhibitors, reverse transcriptase inhibitors and protease inhibitors in a time course mode before assessment by flow cytometry. Codice articolo 9783844334241
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Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals | Modulation of Human Immunodeficiency Virus Type-1 Co-Receptors Expression on the Cell Surface by Anti-Viral Compounds
Editore:
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844334246
ISBN 13: 9783844334241
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Taschenbuch. Condizione: Neu. Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals | Modulation of Human Immunodeficiency Virus Type-1 Co-Receptors Expression on the Cell Surface by Anti-Viral Compounds | Daniel Y Adu | Taschenbuch | 92 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783844334241 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Codice articolo 106954976
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