Modeling Cellular Signaling Systems: An Abstraction-Refinement Approach - Brossura

Hermith, Diana

Brossura

ISBN 10: 384653756X ISBN 13: 9783846537565

Casa editrice: LAP LAMBERT Academic Publishing, 2011

Riassunto

At the cellular level, theorize about the molecular mechanisms of cells to communicate with the environment implies to take into consideration concurrent processes, elements, and relationships that define the functionality of cells over time. The cell-membrane, the surface that acts as a boundary contains many receptors which are responsible for interacting with diverse signaling molecules and recognize external information that affects the behavior in a cell. Each receptor detects specific molecules that may bind to it, which activates signaling pathways that regulate molecular mechanisms, the flow and the processing of biochemical information. There is a special class of receptors that constitutes a common target of pharmaceutical drugs, the G protein-coupled receptors (GPCRs). These receptors interact with their respective Guanine nucleotide-binding proteins (G Proteins) to induce an intracellular signaling. In this thesis we study, in a compositional way, interesting biological scenarios in the context of signaling biochemical networks by using the nTCC calculus, a non-deterministic temporal extension of Concurrent Constraint Programming (CCP).

Su questo libro

L'autore

Graduated with an honors master degree in Computer Science. With a Bachelor Science degree in Molecular Biology and in Science, Technology and Society. Interested to understand the integration and the interactions of the components in biological systems. A scientist and humanist, who thinks about the complexity and the expression of life.

Dettagli dell?edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2011
• Lingua: Inglese
• ISBN 10: 384653756X
• ISBN 13: 9783846537565
• Rilegatura: Copertina flessibile
• Numero di pagine: 128
• Contatto del produttore: non disponibile