QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives - Brossura

Jain, Priyal; Jain, Nilesh; Jain, Vaibhav

Brossura

ISBN 10: 3846586021 ISBN 13: 9783846586020

Casa editrice: LAP LAMBERT Academic Publishing, 2012

Riassunto

We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

Su questo libro

L'autore

Priyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.

Dettagli dell?edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2012
• ISBN 10: 3846586021
• ISBN 13: 9783846586020
• Rilegatura: Copertina flessibile
• Lingua: Inglese
• Numero di pagine: 76
• Contatto del produttore: non disponibile