QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives - Brossura

Jain, Priyal; Jain, Nilesh; Jain, Vaibhav

 
9783846586020: QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
Brossura
ISBN 10: 3846586021 ISBN 13: 9783846586020
Casa editrice: LAP LAMBERT Academic Publishing, 2012

Sinossi

We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

L'autore

Priyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
3846586021
ISBN 13 
9783846586020
Rilegatura
Copertina flessibile
Numero di pagine
76
Contatto del produttore
non disponibile
Persona responsabile
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Germania