Articoli correlati a Site-Directed Insertion of Transgenes: 23

Site-Directed Insertion of Transgenes: 23 - Rilegato

Libro 16 di 17: Topics in Current Genetics
 
9789400745308: Site-Directed Insertion of Transgenes: 23
Rilegato
ISBN 10: 9400745303 ISBN 13: 9789400745308
Casa editrice: Springer Nature, 2012

Sinossi

The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, ?C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information s will help students and experienced researchers to understand and choose the best technology for their own purposes.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Dalla quarta di copertina

The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, ?C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information s will help students and experienced researchers to understand and choose the best technology for their own purposes.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
Springer Nature
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
9400745303
ISBN 13 
9789400745308
Rilegatura
Copertina rigida
Numero di pagine
392
Redattore
Renault Sylvaine, Duchateau Philippe
Contatto del produttore
Springer Nature Customer Service Center GmbH
ProductSafety@springernature.com

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