DNA DEAMINATION & THE IMMUNE SYSTEM (V3)

Fugmann Sebastian

ISBN 10: 1848165927 / ISBN 13: 9781848165922

Editore: ICP, 2010

nach der Bestellung gedruckt Neuware - Printed after ordering - This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments. Codice articolo 9781848165922

Riassunto:

This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments.

Dalla quarta di copertina: This monograph covers current understanding of the role of activation induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID and the genetic demonstration of its role in somatic hypermutation and class switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions (How does this enzyme get to the antibody locus leaving the rest of the genome intact? Why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome?) remain hotly contested. These questions will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued monograph summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments.

Dati bibliografici

Titolo: DNA DEAMINATION & THE IMMUNE SYSTEM (V3)
Casa editrice: ICP
Data di pubblicazione: 2010
Legatura: Buch
Condizione: Neu