Evolution Of Multiple Alignments: Towards Efficient Data Exploitation And Knowledge Extraction In The Genomic Era

Thompson, Julie Dawn; Thompson, Julie Dawn

ISBN 10: 3639169328 / ISBN 13: 9783639169324

Editore: Vdm Verlag Dr. Müller, 2009

168 pages. 8.66x5.91x0.38 inches. In Stock. Codice articolo __3639169328

Riassunto:

Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies.

L'autore: Dr. Thompson is a bioinformatics researcher at the National Centre for Scientific Research (CNRS) in France. She received her BSc degree in Mathematics at Sheffield University, UK and her PhD at the Louis Pasteur University, Strasbourg, France.

Dati bibliografici

Titolo: Evolution Of Multiple Alignments: Towards ...
Casa editrice: Vdm Verlag Dr. Müller
Data di pubblicazione: 2009
Legatura: Paperback
Condizione: Brand New