Formulation and Development of Bilayer Floating Tablets of Nifedipine: Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique

Sharma, Dinesh Kumar; Behera, Amulyaratna; Pattnaik, Gurudutta

ISBN 10: 620341087X / ISBN 13: 9786203410877

Editore: LAP LAMBERT Academic Publishing, 2021

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Codice articolo 26395131211

Dati bibliografici

• Titolo: Formulation and Development of Bilayer Floating Tablets of Nifedipine: Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique
• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2021
• Lingua: Inglese
• ISBN 10: 620341087X
• ISBN 13: 9786203410877
• Rilegatura: Brossura
• Condizione: New

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Riassunto

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.