Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology (Advances in Experimental Medicine and Biology) (v. 11)

ISBN 10: 0387465278 / ISBN 13: 9780387465272

Editore: Springer, 2007

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Codice articolo ERICA77303874652786

Dati bibliografici

• Titolo: Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology (Advances in Experimental Medicine and Biology) (v. 11)
• Editore: Springer
• Data di pubblicazione: 2007
• Lingua: Inglese
• ISBN 10: 0387465278
• ISBN 13: 9780387465272
• Rilegatura: Hardcover
• Condizione: Like New
• Tipo di libro: book

Descrizione articolo

Riassunto

In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Contenuti

Regulation and Function of the E2A Proteins in B Cell Development.- Multiple Roles for Blimp-1 in B and T Lymphocytes.- Memory B Cell Evolution: B Cell Biology.- BCR-linked Factors in Developmental Fate Decisions.- Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors.- Rules for the Rearrangement Events at the L Chain Gene Loci of the Mouse.- Regulation of AID Function In Vivo.- Targeting of AID to Immunoglobulin Genes.- Targeting AID to the Ig Genes.- DNA Replication to Aid Somatic Hypermutation.- Regulation of Activation Induced Deaminase via Phosphorylation.- Modulation of MHC Class II Signal Transduction by CD19.- Role of NFUP?B Signaling in Normal and Malignant B Cell Development.- Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function.- Tolerance Mechanisms in the Late Phase of the Antibody Response.- Role of RS/?DE in B Cell Receptor Editing.- The Regulation of Receptor Editing.- B Cell Hyporesponsiveness and Autoimmunity: A New Paradigm.