Sparking Signals : Kinases As Molecular Signaltransducers and Pharmacologial Drug Targets in Inflammation

Baier, G. (EDT); Schraven, B. (EDT); Bonin, A. V. (EDT); Zugel, U. (EDT)

ISBN 10: 3540735003 / ISBN 13: 9783540735007

Editore: Springer, 2008

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Dati bibliografici

• Titolo: Sparking Signals : Kinases As Molecular Signaltransducers and Pharmacologial Drug Targets in Inflammation
• Editore: Springer
• Data di pubblicazione: 2008
• Lingua: Inglese
• ISBN 10: 3540735003
• ISBN 13: 9783540735007
• Rilegatura: Rilegato
• Condizione: New

Descrizione articolo

Riassunto

The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. In this book, well known experts present their most recent findings on the fast developing kinase field. It will be of interest to basic researchers and the pharmaceutical industry.

Contenuti

Proteomics-Based Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T Lymphocytes.- Migration, Cell–Cell Interaction and Adhesion in the Immune System.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.- Systems Biology of T Cell Activation.- Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting, and Regulating PAMPS.- The Role of Diacylglycerol Kinases in T Cell Anergy.