ali mobasheri (31 risultati)

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Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | 1 Introduction Ar ticular cartilage is a specialised connective tissue with unique biological and mechanical properties which depend on the structural design of the tissue and the interactions between its unique resident cells, the chondrocytes, and the extrac- lular matrix (ECM) that makes up the bulk of the tissue (Buckwalter and Mankin 1998). Chondrocytes (Fig. 1 ) are the architects of the ECM (Muir 1995), building the macromolecular framework of the ECM from three distinct classes of mac- molecules: collagens, proteoglycans, and noncollagenous proteins. Of the collagens present in articular cartilage, collagens type II, IX, and XI form a fibrillar meshwork that gives cartilage tensile stiffness and strength (Eyre 2004; Buckwalter and Mankin 1998; Kuettner et al. 1991), whereas collagen type VI forms part of the matrix im- diately surrounding the chondrocytes, enabling them to attach to the macro- lecular framework of the ECM and acting as a transducer of biomechanical and biochemical signals in the articular cartilage (Guilak et al. 2006; Roughley and Lee 1994). Embedded in the collagen mesh are large aggregating proteoglycans (agg- can), which give cartilage its stiffness to compression, its resilience and contribute to its long-term durability (Dudhia 2005; Kiani et al. 2002; Luo et al. 2000; Roughley and Lee 1994). The extracellular matrix proteins in cartilage are of great significance for the regulation of the cell behaviour, proliferation, differentiation and morphogenesis (Kosher et al. 1973; Kosher and Church 1975; von der Mark et al. 1977; Hewitt et al.

Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | 1 Introduction The provision of nutrients and oxygen to synovial joints is essential for the ph ysiological and load-bearing functions of articular cartilage and the hom- static control of metabolism within chondrocytes, its resident cells (Mobasheri et al. 2002c; Mobasheri et al. 2006). The transport of nutrients (i. e. , glucose, other h- ose and pentose sugars, amino acids, nucleotides, nucleosides and water soluble vitamins such as vitamin C) into articular chondrocytes is essential for the synt- sis of collagens, proteoglycans, and glycosaminoglycans by chondrocytes (Clark et al. 2002; Goggs et al. 2005; McNulty et al. 2005; Mobasheri et al. 2002a). There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on cartilage function and pathophysiological events in disease processes including osteoarthritis (McAlindon 2006). A decade ago, very l- tle was known about nutrient transport in chondrocytes, particularly the transport of glucose, related sugars, and water-soluble vitamins, which are essential for the synthesis of glycosaminoglycans by chondrocytes. Glucose is a crucial nutrient for cartilage function in vivo as it is for many other tissues and organs. However, it has always been assumed that glucose is important for the in vitro cultivation of chond- cytes, ex vivo maintenance of cartilage explants, and cartilage tissue engineering procedures.

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Taschenbuch. Condizione: Neu. Facilitative Glucose Transporters in Articular Chondrocytes | Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines | Ali Mobasheri (u. a.) | Taschenbuch | Advances in Anatomy, Embryology and Cell Biology | vii | Englisch | 2013 | Springer | EAN 9783540788980 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - 1 Introduction The provision of nutrients and oxygen to synovial joints is essential for the ph ysiological and load-bearing functions of articular cartilage and the hom- static control of metabolism within chondrocytes, its resident cells (Mobasheri et al. 2002c; Mobasheri et al. 2006). The transport of nutrients (i. e. , glucose, other h- ose and pentose sugars, amino acids, nucleotides, nucleosides and water soluble vitamins such as vitamin C) into articular chondrocytes is essential for the synt- sis of collagens, proteoglycans, and glycosaminoglycans by chondrocytes (Clark et al. 2002; Goggs et al. 2005; McNulty et al. 2005; Mobasheri et al. 2002a). There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on cartilage function and pathophysiological events in disease processes including osteoarthritis (McAlindon 2006). A decade ago, very l- tle was known about nutrient transport in chondrocytes, particularly the transport of glucose, related sugars, and water-soluble vitamins, which are essential for the synthesis of glycosaminoglycans by chondrocytes. Glucose is a crucial nutrient for cartilage function in vivo as it is for many other tissues and organs. However, it has always been assumed that glucose is important for the in vitro cultivation of chond- cytes, ex vivo maintenance of cartilage explants, and cartilage tissue engineering procedures.

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Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume explores a collection of methodologies used to study the complexities of biological membranes and the associated surfaceome. The chapters in this book aim to facilitate the adoption of innovative methods to help researchers advance their understanding of the biology of membranes and their role in health and disease. Written in the highly successfulMethods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.Comprehensive and cutting-edge, The Surfaceome: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important and developing field.

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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1 Introduction The provision of nutrients and oxygen to synovial joints is essential for the ph ysiological and load-bearing functions of articular cartilage and the hom- static control of metabolism within chondrocytes, its resident cells (Mobasheri et al. 2002c; Mobasheri et al. 2006). The transport of nutrients (i. e. , glucose, other h- ose and pentose sugars, amino acids, nucleotides, nucleosides and water soluble vitamins such as vitamin C) into articular chondrocytes is essential for the synt- sis of collagens, proteoglycans, and glycosaminoglycans by chondrocytes (Clark et al. 2002; Goggs et al. 2005; McNulty et al. 2005; Mobasheri et al. 2002a). There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on cartilage function and pathophysiological events in disease processes including osteoarthritis (McAlindon 2006). A decade ago, very l- tle was known about nutrient transport in chondrocytes, particularly the transport of glucose, related sugars, and water-soluble vitamins, which are essential for the synthesis of glycosaminoglycans by chondrocytes. Glucose is a crucial nutrient for cartilage function in vivo as it is for many other tissues and organs. However, it has always been assumed that glucose is important for the in vitro cultivation of chond- cytes, ex vivo maintenance of cartilage explants, and cartilage tissue engineering procedures. 100 pp. Englisch.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Integrins in Articular Cartilage.- Concluding Remarks.Integrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Articular Cartilage: Structure, Function, and Pathophysiology.- Does Arthritis Have a Nutritional Etiology?.- Metabolic Dysfunction in Arthritis.- Glucose: An Essential Metabolite and Structural Precursor for Articular Cartilage.- Mammalian Sugar Transporte.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Articular Cartilage: Structure, Function, and Pathophysiology.- Does Arthritis Have a Nutritional Etiology .- Metabolic Dysfunction in Arthritis.- Glucose: An Essential Metabolite and Structural Precursor for Articular Cartilage.- Mammalian Sugar Transporter Families: GLUT and SGLT.- Molecular Diversity of Facilitative Glucose Transporters in Articular Chondrocytes.- Regulation of Glucose Transport by Nonsteroidal Anti-inflammatory Drugs.- Glucose Transporters in the Intervertebral Disc.- Glucose Transporter Expression and Regulation in Embryonic and Mesenchymal Stem Cells.- Concluding Remarks.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 100 pp. Englisch.

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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume explores a collection of methodologies used to study the complexities of biological membranes and the associated surfaceome. The chapters in this book aim to facilitate the adoption of innovative methods to help researchers advance their understanding of the biology of membranes and their role in health and disease. Written in the highly successfulMethods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.Comprehensive and cutting-edge, The Surfaceome: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important and developing field. 279 pp. Englisch.

Condizione: New. Print on Demand.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume explores a collection of methodologies used to study the complexities of biological membranes and the associated surfaceome. The chapters in this book aim to facilitate the adoption of innovative methods to help researchers advance their understanding of the biology of membranes and their role in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.Comprehensive and cutting-edge, The Surfaceome: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important and developing field.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 292 pp. Englisch.

Hardcover. Condizione: new. Hardcover. This volume explores a collection of methodologies used to study the complexities of biological membranes and the associated surfaceome. The chapters in this book aim to facilitate the adoption of innovative methods to help researchers advance their understanding of the biology of membranes and their role in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.Comprehensive and cutting-edge, The Surfaceome: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this important and developing field. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.