baiker martin (4 risultati)

Taschenbuch. Condizione: Neu. 3-D Visualisation of Chicken Embryo Vasculature | Assessment of staining methods for geometric vessel reconstruction and numerical simulation of blood flow-induced wall shear stress | Martin Baiker | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639155365 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Baiker MartinMartin Baiker obtained a MSc degree in Biomed. Eng. (cum laude)nfrom the TU Delft, The Netherlands, and is currently a PhDncandidate at the Leiden University Medical Center, The Netherlands.nProf. Jerry Westerweel holds .

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Shear stress responsive genes in the vessel walls ofthe developing chicken embryo have a large impact onthe development of the vasculature. To investigatethe effect of altered blood flow on vessel formation,blood velocity profiles have to be known close to thevessel walls. However, the determination of the exactvessel geometry is difficult, because the vessels arevery small (10 to 250 micrometres) and almosttransparent. This thesis investigates severalpossibilities to stain the endothelium (the celllayer at the inner boundary of a vessel) of chickenembryo vasculature, using animals after 2-4 days ofincubation (HH14-17), in order to make it visiblewith fluorescence microscopy. The most suitablestaining methods are subsequently used to stain theendothelium of HH14 chicken embryo hearts and 3Ddatasets are acquired by means of confocalmicroscopy. Based on these datasets, geometric modelsare reconstructed and, using a numerical flowsimulation package, blood flow-induced wall shearstress distributions are determined. Subsequently,the results of the simulations are related to recentresearch data about expressions of shear stressresponsive genes of the endothelium.