Douglas lappi (44 risultati)

hardcover. Condizione: New. In shrink wrap. Looks like an interesting title.

Hardcover. Condizione: Very Good. No Jacket. Very Good condition hardcover book, no dust jacket. Shelf wear to covers. Bumping to spine ends. Pages lightly toned and smudged at text block edges and margins, pages are otherwise clean and unmarked. All books are individually inspected and described. Never X-Library unless specifically described as such. …

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

hardcover. Condizione: Very Good. 2014 signed and inscribed first edition, association copy (1977 Nobel winner Roger Guillemin), 7 x 9 7/8 inches tall color pictorial hardcover, no dust jacket (as issued), illustrated with color and black-and-white diagrams and drawings, index, xii, 296 pp. Laid in is a slip reading, 'From the Private Colllection of Dr. Roger and Lucienne Guillemin, Nobel Laureate, 1977, Salk Institute, La Jolla, CA.' Roger Charles Louis Guillemin (1924-2024) was a French-American neuroscientist who received the National Medal of Science in 1976, and the Nobel Prize for Medicine in 1977 for his work on neurohormones. Very slight soiling, rubbing and edgewear to covers. On the title page, nicely signed by author Douglas Lappi and inscribed to Guillemin, widely considered the 'father of neuroendocrinology' and winner of the Nobel prize for medicine. Otherwise, a very good to near fine copy - clean, bright and unmarked. ~SP19~ [2.5P] This important reference provides information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain. Contents: Preface; 1 Introduction and History; Introduction; Identification and Distribution in Nature; Mechanism of Action; Effects on Cells and Animals; Role in Nature; Practical Applications; Bioweapons; Future Challenges; References; 2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily; Introduction; How to Investigate the Distribution of Proteins with an N-glycosidase Domain?; Conclusions; Acknowledgments. IntroductionFamily Sambuceae; Type 2 RIPs from Other families; Uses of nontoxic type 2 RIPs; Concluding remarks; Acknowledgment; References; 6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins; Introduction; Cell Surface Events; Endosome to TGN Sorting; From the Golgi to the ER; Reductive Separation and Destabilization of the Holotoxin Subunits; Dislocation Across the ERâ?0 embrane; Cytosolic Post-dislocation Events that Restore Catalytic Activity; Concluding Remarks; Acknowledgements; References. 7 Shiga ToxinsIntroduction; Purification of Shiga Toxins; Structure and Mechanism of Action of Shiga Toxins; Role of Shiga Toxins in the Pathogenesis of HUS; The 2011 German STEC Outbreak; References; 8 The Structure and Action of Ribosome-inactivating Proteins; Introduction; Acknowledgments; References; 9 Updated Model of the Molecular Evolution of RIP Genes; Introduction; Important Issues to be Considered in View of the Evolution of RIP Genes. Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome DataNew Insights in the Overall Phylogeny of Plant RIPs; An Updated Model of the Molecular Evolution of the Plant RIP Gene Family; What is the Evolutionary Link Between Plant and Non-Plant RIPs?; Conclusions; References; 10 Enzymology of the Ribosome-inactivating Proteins; Introduction; Ricin as RNA N-glycosidase; Role of SRL in Ribosomes; Ribosomal RNA Apurinic Site-specific Lyase Intrinsic Stability of the Ribosomes; Action of RIPs on DNA.…

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: New.

Condizione: New.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: As New. Unread book in perfect condition.

Condizione: Used. pp. 328 1st Edition.

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: New.

Condizione: As New. Unread book in perfect condition.

Condizione: Used. pp. 328.

Condizione: Used. pp. 328.

Condizione: New. This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Editor(s): Stirpe, Fiorenzo; Lappi, Douglas. Num Pages: 328 pages, black & white illustrations, black & white line drawings, black & white tables, figures, BIC Classification: MJCM; PSBC. Category: (P) Professional & Vocational. Dimension: 251 x 169 x 20. Weight in Grams: 812. . 2014. 1st Edition. Hardcover. . . . .…

Taschenbuch. Condizione: Neu. Molecular Neurosurgery with Targeted Toxins | Ronald G. Wiley (u. a.) | Taschenbuch | xii | Englisch | 2010 | Humana | EAN 9781617374203 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Condizione: New. Brand new! Please provide a physical shipping address.

Condizione: New. pp. 328.

Condizione: New.

Condizione: New.

Paperback. Condizione: Brand New. reprint edition. 328 pages. 9.45x6.30x0.73 inches. In Stock.

Condizione: New. In English.

Condizione: New. Fiorenzo Stirpe is Professor Emeritus at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.Douglas A. Lappi is the President and Chief Scientific Officer of Advanced Targeting Systems, USA.Ribosome-inactivat.

Condizione: New. This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Editor(s): Stirpe, Fiorenzo; Lappi, Douglas. Num Pages: 328 pages, black & white illustrations, black & white line drawings, black & white tables, figures, BIC Classification: MJCM; PSBC. Category: (P) Professional & Vocational. Dimension: 251 x 169 x 20. Weight in Grams: 812. . 2014. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.…

Condizione: As New. Unread book in perfect condition.

Condizione: New. Gives a treatment of the highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. This book explains the theory and techniques of using targeted toxins experimentally. Editor(s): Wiley, Ronald G.; Lappi, Douglas. Num Pages: 312 pages, biography. Category: (G) General (US: Trade); (P) Professional & Vocational; (U) Tertiary Education (US: College). Dimension: 235 x 155 x 21. Weight in Grams: 654. . 2005. Hardback. . . . .…

Buch. Condizione: Neu. Neuware - This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.…