g lubec (29 risultati)

Condizione: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1000grams, ISBN:9783211407813.

Condizione: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1000grams, ISBN:9783211407813.

8pp, 4 figs, Card Cover, VGC,

Condizione: Like New. Used - Like New. This is a brand new book! Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.

Condizione: New.

Condizione: New.

Condizione: New. In.

Condizione: New. In.

Paperback. Condizione: Brand New. 242 pages. 10.80x8.20x0.40 inches. In Stock.

Condizione: New.

Paperback. Condizione: New. This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology. Softcover reprint of the original 1st ed. 1999.

hardcover. Condizione: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Taschenbuch. Condizione: Neu. The Molecular Biology of Down Syndrome | G. Lubec | Taschenbuch | x | Englisch | 1999 | Springer | EAN 9783211833773 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Gebunden. Condizione: New.

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.

Condizione: New. pp. 362 1st Edition.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.

Hardcover. Condizione: Like New. Like New. book.

Hardcover. Condizione: Brand New. 1st edition. 372 pages. 10.75x8.25x1.00 inches. In Stock.

Paperback. Condizione: New. Softcover reprint of the original 1st ed. 1999.

Buch. Condizione: Neu. Neuware - When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.

Paperback. Condizione: Brand New. 1st edition. 362 pages. 10.75x8.25x0.75 inches. In Stock.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology. 380 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology. 380 pp. Englisch.

Buch. Condizione: Neu. The Molecular Biology of Down Syndrome | G. Lubec | Buch | Englisch | 1999 | Springer | EAN 9783211833780 | Verantwortliche Person für die EU: Springer Wien, Prinz-Eugen-Str. 8-10, 1040 WIEN, ÖSTERREICH, buchhandel-buch[at]springer[dot]com | Anbieter: preigu Print on Demand.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 380 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer's neurodegeneration.- Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome.- The Down Syndrome critical region.- Neuropathology.- c-fos expression in brains of patients with Down Syndrome.- Neuronal cell death in Down's syndrome.- Altered Gene expression in fetal Down Syndrome brain as revealed by the Gene huntinG technique of subtractive hybridization.- Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization.- Molecular misreadinG of Genes in Down syndrome as a model for the Alzheimer type of neurodegeneration.- Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.- Gene expression relevant to Down Syndrome: problems and approaches.- Isolation and analysis of chromosome 21 Genes potentially involved in Down Syndrome.- Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome.- Serotonin (5-HT) in brains of adult patients with Down Syndrome.- Mechanisms of neuronal death in Down's syndrome.- Impaired brain Glucose metabolism in patients with Down Syndrome.- Oxidative stress and neural dysfunction in Down Syndrome.- Expression of the transcription factor ETS2 in brain of patients with Down Syndrome - evidence against the overexpression-Gene dosage hypothesis.- Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down Syndrome.- The 'Gene dosage effect' hypothesis versus the 'amplified developmental instability' hypothesis in Down Syndrome.- Downregulation of the transcription factorscleraxis in brain of patients with Down Syndrome.- Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer's disease.- Increased levels of 14-3-3 Gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down Syndrome.- Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin.- Overexpression of DNAse I in brain of patients with Down Syndrome.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 380 pp. Englisch.

Condizione: New. Print on Demand pp. 362.

Condizione: New. PRINT ON DEMAND pp. 362.