Da: Midtown Scholar Bookstore, Harrisburg, PA, U.S.A.
Hardcover. Condizione: Good. HARDCOVER Good - Bumped and creased book with tears to the extremities, but not affecting the text block, may have remainder mark or previous owner's name - GOOD Standard-sized.
EUR 69,95
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Aggiungi al carrelloPaperback. Condizione: New. Softcover reprint of the original 1st ed. 1994.
Da: BOOKWEST, Phoenix, AZ, U.S.A.
Prima edizione
Hardcover. Condizione: New. 1st Edition. US SELLER SHIPS FAST FROM USA.
Da: Ria Christie Collections, Uxbridge, Regno Unito
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Da: Ria Christie Collections, Uxbridge, Regno Unito
EUR 60,33
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Da: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irlanda
EUR 70,81
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Aggiungi al carrelloCondizione: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . .
Condizione: New. pp. 508.
Condizione: New. pp. 530.
Da: Revaluation Books, Exeter, Regno Unito
EUR 83,08
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Aggiungi al carrelloPaperback. Condizione: Brand New. reprint edition. 509 pages. 9.00x6.00x1.25 inches. In Stock.
Condizione: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . . Books ship from the US and Ireland.
EUR 50,35
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Alzheimer Disease | Therapeutic Strategies | Ezio Giacobini (u. a.) | Taschenbuch | xvi | Englisch | 2012 | Birkhäuser | EAN 9781461581512 | Verantwortliche Person für die EU: Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
EUR 59,97
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Da: Mispah books, Redhill, SURRE, Regno Unito
EUR 102,14
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Aggiungi al carrelloPaperback. Condizione: Like New. Like New. book.
Da: Mispah books, Redhill, SURRE, Regno Unito
EUR 105,70
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Aggiungi al carrelloPaperback. Condizione: Like New. Like New. book.
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Aggiungi al carrelloPaperback. Condizione: New. Softcover reprint of the original 1st ed. 1994.
EUR 47,63
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Aggiungi al carrelloCondizione: Sehr gut. Zustand: Sehr gut | Seiten: 528 | Sprache: Englisch | Produktart: Bücher | Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
EUR 155,99
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Aggiungi al carrelloCondizione: Used. pp. 632.
Da: GreatBookPricesUK, Woodford Green, Regno Unito
EUR 248,62
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EUR 273,70
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Da: GreatBookPricesUK, Woodford Green, Regno Unito
EUR 272,21
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Aggiungi al carrelloCondizione: As New. Unread book in perfect condition.
Da: Brook Bookstore On Demand, Napoli, NA, Italia
EUR 46,22
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Aggiungi al carrelloCondizione: new. Questo è un articolo print on demand.
Lingua: Inglese
Editore: Birkhäuser Boston Mai 2012, 2012
ISBN 10: 1461581516 ISBN 13: 9781461581512
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
EUR 53,49
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis. 528 pp. Englisch.
Da: Majestic Books, Hounslow, Regno Unito
EUR 83,15
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Aggiungi al carrelloCondizione: New. Print on Demand pp. 508 49:B&W 6.14 x 9.21 in or 234 x 156 mm (Royal 8vo) Perfect Bound on White w/Gloss Lam.
Da: Biblios, Frankfurt am main, HESSE, Germania
EUR 80,59
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Aggiungi al carrelloCondizione: New. PRINT ON DEMAND pp. 508.
Da: Majestic Books, Hounslow, Regno Unito
EUR 90,96
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Aggiungi al carrelloCondizione: New. Print on Demand pp. 530.
Da: moluna, Greven, Germania
EUR 48,37
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Aggiungi al carrelloCondizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critic.
Da: moluna, Greven, Germania
EUR 48,37
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Aggiungi al carrelloCondizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Springer Book Archives.
Da: Biblios, Frankfurt am main, HESSE, Germania
EUR 89,73
Quantità: 4 disponibili
Aggiungi al carrelloCondizione: New. PRINT ON DEMAND pp. 530.