Gianpaolo rando (5 risultati)

Taschenbuch. Condizione: Neu. Taxonomy of drug activity in vivo | A case study with selective estrogen receptor modulators | Gianpaolo Rando | Taschenbuch | 80 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838376448 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For more than one century, the measure of drug structure-activity relationships has been based on mathematical equations describing the drug interaction with its biological receptor. This analysis fails to evaluate a critical part of a therapy that is the dynamic response of the organism to the pharmacological assault: this response occurs within an unpredictable time window. Therefore, by introducing the time dimension in the study of drug effects, we might increase our ability to predict the therapeutic efficacy of a given compound. Here, the space-temporal activation of drug targets is proposed as a measure of drug efficacy. The validity of this theory is demonstrated using imaging technologies and a reporter mouse in which drug action can be measured non-invasively. As a practical example, the taxonomy of selective estrogen receptor modulators (subject of my PhD dissertation with Prof. Adriana Maggi) is discussed. We show that the space-temporal analysis of a biological function leads to the taxonomy of structurally-related compounds. This methodology could facilitate the pre-clinical to clinical transition. 80 pp. Englisch.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Rando Gianpaoloobtained a M.Sc. in Biotechnology in 2005 and a Ph.D. in Pharmacology in 2008 at the University of Milan working with in vivo imaging. Now, he conducts his research at the Center for Integrative Genomics of the Univ.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -For more than one century, the measure of drug structure-activity relationships has been based on mathematical equations describing the drug interaction with its biological receptor. This analysis fails to evaluate a critical part of a therapy that is the dynamic response of the organism to the pharmacological assault: this response occurs within an unpredictable time window. Therefore, by introducing the time dimension in the study of drug effects, we might increase our ability to predict the therapeutic efficacy of a given compound. Here, the space-temporal activation of drug targets is proposed as a measure of drug efficacy. The validity of this theory is demonstrated using imaging technologies and a reporter mouse in which drug action can be measured non-invasively. As a practical example, the taxonomy of selective estrogen receptor modulators (subject of my PhD dissertation with Prof. Adriana Maggi) is discussed. We show that the space-temporal analysis of a biological function leads to the taxonomy of structurally-related compounds. This methodology could facilitate the pre-clinical to clinical transition.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 80 pp. Englisch.…

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - For more than one century, the measure of drug structure-activity relationships has been based on mathematical equations describing the drug interaction with its biological receptor. This analysis fails to evaluate a critical part of a therapy that is the dynamic response of the organism to the pharmacological assault: this response occurs within an unpredictable time window. Therefore, by introducing the time dimension in the study of drug effects, we might increase our ability to predict the therapeutic efficacy of a given compound. Here, the space-temporal activation of drug targets is proposed as a measure of drug efficacy. The validity of this theory is demonstrated using imaging technologies and a reporter mouse in which drug action can be measured non-invasively. As a practical example, the taxonomy of selective estrogen receptor modulators (subject of my PhD dissertation with Prof. Adriana Maggi) is discussed. We show that the space-temporal analysis of a biological function leads to the taxonomy of structurally-related compounds. This methodology could facilitate the pre-clinical to clinical transition.…