Haj christeene (8 risultati)

Condizione: New.

Condizione: New. In English.

PF. Condizione: New. This item is printed on demand. Brand new book, sourced directly from publisher. Dispatch time is 6-7 days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

PAP. Condizione: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Haj ChristeeneChristeene G. Haj, PhD: Studied Chemistry,Medicinal Chemistry and Natural Products at the Hebrew University Of Jerusalem. Post-Doc student at the School of Pharmacy, The Hebrew University Of Jerusalem.Cannabidiol (C.…

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cannabidiol (CBD) is a nonpsychoactive component of cannabis with a high potential for use in several therapeutic areas. It binds very weakly to the CB1 and CB2. It has been evaluated both in vitro and in vivo in anti-inflammatory assays. Thus, it lowers the formation of TNF- , a proinflammatory cytokine, in vitro, and was found to be an oral anti-arthritic therapeutic in murine collagen-induced arthritis in vivo. Its numerous potentially therapeutic pharmacological effects may be due in part to its metabolites. Indeed, a derivative of such a metabolite, CBD-dimethylheptyl (DMH)-7-oic-acid (HU-320) is more potent than CBD as an anti-arthritic agent in the above model of CIA. Several synthetic enantiomeric (+)-CBD derivatives, have been found to be bind to the CB1 receptor, but have only peripheral action and may not be able to cross the blood-brain barrier while its 7-OH-counterpart , (+)-7-OH-cannabidiol-DMH does cross the blood-brain barrier. The lack of central effects may make possible the development of such derivative as peripheral anti-inflammatory drugs.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cannabidiol (CBD) is a nonpsychoactive component of cannabis with a high potential for use in several therapeutic areas. It binds very weakly to the CB1 and CB2. It has been evaluated both in vitro and in vivo in anti-inflammatory assays. Thus, it lowers the formation of TNF-¿, a proinflammatory cytokine, in vitro, and was found to be an oral anti-arthritic therapeutic in murine collagen-induced arthritis in vivo. Its numerous potentially therapeutic pharmacological effects may be due in part to its metabolites. Indeed, a derivative of such a metabolite, CBD-dimethylheptyl (DMH)-7-oic-acid (HU-320) is more potent than CBD as an anti-arthritic agent in the above model of CIA. Several synthetic enantiomeric (+)-CBD derivatives, have been found to be bind to the CB1 receptor, but have only peripheral action and may not be able to cross the blood-brain barrier while its 7-OH-counterpart , (+)-7-OH-cannabidiol-DMH does cross the blood-brain barrier. The lack of central effects may make possible the development of such derivative as peripheral anti-inflammatory drugs.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 152 pp. Englisch.…