James e talmadge (35 risultati)
Georgia Voices: Volume 2: Nonfiction
Ruppersburg, Hugh [Editor]; Oglethorpe, James [Contributor]; Kemble, Frances Anne [Contributor]; Craft, William [Contributor]; Harris, Joel Chandler [Contributor]; Harris, Corra [Contributor]; Du Bois, W. E. B. [Contributor]; Wade, John Donald [Contributor]; Talmadge, John [Contributor]; Lumpkin, Katharine Du Pre [Contributor]; White, Walter [Contributor]; Smith, Lillian [Contributor]; Aiken, Conrad [Contributor]; McGill, Ralph [Contributor]; King Jr., Martin Luther [Contributor]; Windham, Donald [Contributor]; Caldwell, Erskine [Contributor]; O'Connor, Flannery [Contributor]; Walker, Alice [Contributor]; Crews, Harry [Contributor]; Daniell, Rosemary [Contributor]; Blount Jr., Roy [Contributor]; Williams, Philip Lee [Contributor]; Andrews,
- Brossura
Da: Adkins Books, Chattanooga, TN, U.S.A.Adkins Books
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Molto buono
EUR 8,86
EUR 3,45 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
paperback. Condizione: Very Good. Free of markings.
Mike Shayne - Mystery Magazine (Pulp Digest Magazine); Vol. 45, No.4 April 1981 Published by Renown Publications Inc. Fit for A Corpse by Brett Halliday; Gary Alexander; Richard Deming; Hal Ellson; Edward D. Hoch; E.L Knouse; Talmadge Powell; Peter Magn
Brett Halliday; Edward D.Hoch; Richard Deming; Talmadge Powell; Peter Death; Gary Alexandra; Hal Ellson; E.L Knouse; Lenora K. Rogers; James M. Reasoner; Paul Young
Editore: Renown Publications, Inc., New York, NY, USA. 1981
- Brossura
- Prima edizione
Da: Comic World, Steinbach, MB, CanadaComic World
Contatta il venditoreVenditore con 5 stelleCondizione: Usato
EUR 8,01
EUR 6,83 spedizioneSpedito da Canada a U.S.A.Quantità: 1 disponibili
Soft cover. Condizione: Very Good to Fine. First Collected Edition, PBO thus.. **FEATURE AND NOVELETS (1) Fit for a corpse by Brett Halliday **STORIES (1) Rubbish by Edward D.Hoch (2) Mother Love by Richard Deming (3) The beacon by Talmadge Powell (4) Faith unto death by Peter death (5) Personality conflict by Gary Alexandra (6)… Salami on rye by Hal Ellson (7) Deadly Sunday by E.L Knouse (8) Another close call by Lenora K. Rogers (9) Outback by James M. Reasoner (10) Dont the windows look nice by Paul Young. >> Minor cover creaisng; Size: 12mo - over 6¾" - 7¾" tall. GGA - {Good Girl Art) Painted Cover (illustratore). Book.
Mike Shayne - Mystery Magazine (Pulp Digest Magazine); Vol. 45, No.4 April 1981 Published by Renown Publications Inc. Fit for A Corpse by Brett Halliday; Gary Alexander; Richard Deming; Hal Ellson; Edward D. Hoch; E.L Knouse; Talmadge Powell; Peter Magn
Brett Halliday; Edward D.Hoch; Richard Deming; Talmadge Powell; Peter Death; Gary Alexandra; Hal Ellson; E.L Knouse; Lenora K. Rogers; James M. Reasoner; Paul Young
Editore: Renown Publications, Inc., New York, NY, USA. 1981
- Brossura
- Prima edizione
Da: Comic World, Steinbach, MB, CanadaComic World
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Ottimo
EUR 10,68
EUR 6,83 spedizioneSpedito da Canada a U.S.A.Quantità: 1 disponibili
Soft cover. Condizione: Fine. First Collected Edition, PBO thus.. **FEATURE AND NOVELETS (1) Fit for a corpse by Brett Halliday **STORIES (1) Rubbish by Edward D.Hoch (2) Mother Love by Richard Deming (3) The beacon by Talmadge Powell (4) Faith unto death by Peter death (5) Personality conflict by Gary Alexandra (6) Salami on ry…e by Hal Ellson (7) Deadly Sunday by E.L Knouse (8) Another close call by Lenora K. Rogers (9) Outback by James M. Reasoner (10) Dont the windows look nice by Paul Young Size: 12mo - over 6¾" - 7¾" tall. GGA - {Good Girl Art) Painted Cover (illustratore). Book.
Editore: LDS January 1924 1924
- Rilegato
Da: The Book Garden, Bountiful, UT, U.S.A.The Book Garden
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EUR 17,80
EUR 6,26 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
Hardcover. Condizione: Very Good - Cash. No Jacket. Thirteenth Edition 1924. Light rubbing and edge wear to cover, with light reader wear to pages. Body of text appears crisp clean and unmarked. Tight binding. Still great condition. Stock photos may not look exactly like the book.
Editore: LDS 1924
- Rilegato
Da: Hawking Books, Edgewood, TX, U.S.A.Hawking Books
Contatta il venditoreVenditore con 4 stelleCondizione: Usato - Discreto
EUR 26,45
Spedizione gratuitaSpedito in U.S.A.Quantità: 1 disponibili
Hardcover. Condizione: Acceptable. Missing dust jacket; otherwise in excellent condition. Acceptable Condition. Five star seller - Buy with confidence.
Editore: LDS
- Rilegato
Da: ThriftBooks-Atlanta, AUSTELL, GA, U.S.A.ThriftBooks-Atlanta
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Discreto
EUR 26,61
Spedizione gratuitaSpedito in U.S.A.Quantità: 1 disponibili
Hardcover. Condizione: Fair. No Jacket. Missing dust jacket; Readable copy. Pages may have considerable notes/highlighting. ~ ThriftBooks: Read More, Spend Less.
Myeloid-Derived Suppressor Cells and Cancer
Escors, David; Talmadge, James E.; Breckpot, Karine; Van Ginderachter, Jo A.; Kochan, Grazyna
Lingua: Inglese
Editore: Springer 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
Da: GreatBookPrices, Columbia, MD, U.S.A.GreatBookPrices
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Come nuovo
EUR 50,01
EUR 2,28 spedizioneSpedito in U.S.A.Quantità: Più di 20 disponibili
Condizione: As New. Unread book in perfect condition.
Myeloid-Derived Suppressor Cells and Cancer
Escors, David; Talmadge, James E.; Breckpot, Karine; Van Ginderachter, Jo A.; Kochan, Grazyna
Lingua: Inglese
Editore: Springer 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
Da: GreatBookPrices, Columbia, MD, U.S.A.GreatBookPrices
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 50,62
EUR 2,28 spedizioneSpedito in U.S.A.Quantità: Più di 20 disponibili
Condizione: New.
Editore: The Church of Jesus Christ of Latter Day Saints
- Rilegato
Da: The Book Garden, Bountiful, UT, U.S.A.The Book Garden
Contatta il venditoreVenditore con 5 stelleCondizione: Usato
EUR 35,59
EUR 6,26 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
Leather. Condizione: Very Good - Cash. Beautiful dark leather with vibrant gold text on the spine. Birthday inscription inside from 1926, other pages are unmarked. Some light general rubbing to the cover and pages. Red/Gold page edges. Stock photos may not look exactly like the book.
Georgia Voices: Volume 2: Nonfiction
Ruppersburg, Hugh [Editor]; Oglethorpe, James [Contributor]; Kemble, Frances Anne [Contributor]; Craft, William [Contributor]; Harris, Joel Chandler [Contributor]; Harris, Corra [Contributor]; Du Bois, W. E. B. [Contributor]; Wade, John Donald [Contributor]; Talmadge, John [Contributor]; Lumpkin, Katharine Du Pre [Contributor]; White, Walter [Contributor]; Smith, Lillian [Contributor]; Aiken, Conrad [Contributor]; McGill, Ralph [Contributor]; King Jr., Martin Luther [Contributor]; Windham, Donald [Contributor]; Caldwell, Erskine [Contributor]; O'Connor, Flannery [Contributor]; Walker, Alice [Contributor]; Crews, Harry [Contributor]; Daniell, Rosemary [Contributor]; Blount Jr., Roy [Contributor]; Williams, Philip Lee [Contributor]; Andrews,
- Brossura
Da: BennettBooksLtd, Los Angeles, CA, U.S.A.BennettBooksLtd
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 68,41
EUR 6,00 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
paperback. Condizione: New. In shrink wrap. Looks like an interesting title.
Myeloid-Derived Suppressor Cells and Cancer
Escors, David; Talmadge, James E.; Breckpot, Karine; Van Ginderachter, Jo A.; Kochan, Grazyna
Lingua: Inglese
Editore: Springer 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
Da: GreatBookPricesUK, Woodford Green, Regno UnitoGreatBookPricesUK
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 58,88
EUR 17,38 spedizioneSpedito da Regno Unito a U.S.A.Quantità: Più di 20 disponibili
Condizione: New.
Myeloid-Derived Suppressor Cells and Cancer
Escors, David; Talmadge, James E.; Breckpot, Karine; Van Ginderachter, Jo A.; Kochan, Grazyna
Lingua: Inglese
Editore: Springer 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
Da: GreatBookPricesUK, Woodford Green, Regno UnitoGreatBookPricesUK
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Come nuovo
EUR 66,75
EUR 17,38 spedizioneSpedito da Regno Unito a U.S.A.Quantità: Più di 20 disponibili
Condizione: As New. Unread book in perfect condition.
- Rilegato
Da: Once Upon A Time Books, Siloam Springs, AR, U.S.A.Once Upon A Time Books
Contatta il venditoreVenditore con 4 stelleCondizione: Usato - Discreto
EUR 83,21
EUR 3,41 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
hardcover. Condizione: Acceptable. This is a used book. It may contain highlighting/underlining and/or the book may show heavier signs of wear . It may also be ex-library or without dustjacket. This is a used book. It may contain highlighting/underlining and/or the book may show heavier signs of wear . It may also be ex-library…or without dustjacket.
Lingua: Inglese
Editore: Springer Verlag 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
Da: Revaluation Books, Exeter, , Regno UnitoRevaluation Books
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 76,07
EUR 11,59 spedizioneSpedito da Regno Unito a U.S.A.Quantità: 2 disponibili
Paperback. Condizione: Brand New. 1st edition. 102 pages. 8.75x6.00x0.25 inches. In Stock.
Lingua: Inglese
Editore: Springer 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
Da: Ria Christie Collections, Uxbridge, Regno UnitoRia Christie Collections
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 115,65
EUR 13,88 spedizioneSpedito da Regno Unito a U.S.A.Quantità: Più di 20 disponibili
Condizione: New. In.
Lingua: Inglese
Editore: Springer 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
Da: Ria Christie Collections, Uxbridge, Regno UnitoRia Christie Collections
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 115,65
EUR 13,88 spedizioneSpedito da Regno Unito a U.S.A.Quantità: Più di 20 disponibili
Condizione: New. In.
Lingua: Inglese
Editore: Springer 2011-11 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
Da: Chiron Media, Wallingford, , Regno UnitoChiron Media
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 113,14
EUR 17,95 spedizioneSpedito da Regno Unito a U.S.A.Quantità: 10 disponibili
PF. Condizione: New.
Lingua: Inglese
Editore: Springer 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
Da: Books Puddle, New York, NY, U.S.A.Books Puddle
Contatta il venditoreVenditore con 4 stelleCondizione: Nuovo
EUR 160,23
EUR 3,45 spedizioneSpedito in U.S.A.Quantità: 4 disponibili
Condizione: New. pp. 212.
Lingua: Inglese
Editore: Springer, Springer 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 112,77
EUR 61,65 spedizioneSpedito da Germania a U.S.A.Quantità: 1 disponibili
Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a… search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).
Lingua: Inglese
Editore: Springer US, Springer US 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 114,36
EUR 62,45 spedizioneSpedito da Germania a U.S.A.Quantità: 1 disponibili
Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search… for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).
Lingua: Inglese
Editore: Springer 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
Da: Mispah books, Redhill, SURRE, Regno UnitoMispah books
Contatta il venditoreVenditore con 4 stelleCondizione: Usato - Molto buono
EUR 185,02
EUR 28,97 spedizioneSpedito da Regno Unito a U.S.A.Quantità: 1 disponibili
Hardcover. Condizione: Very Good. Very Good. book.
Lingua: Inglese
Editore: Springer 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
Da: Mispah books, Redhill, SURRE, Regno UnitoMispah books
Contatta il venditoreVenditore con 4 stelleCondizione: Usato - Come nuovo
EUR 185,02
EUR 28,97 spedizioneSpedito da Regno Unito a U.S.A.Quantità: 1 disponibili
Paperback. Condizione: Like New. Like New. book.
Baum's Textbook of Pulmonary Diseases
Glassroth, Jeffrey, M.D.; Karlinsky, Joel B.; King, Talmadge E.
- Rilegato
Da: Buchpark, Trebbin, , GermaniaBuchpark
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Ottimo
EUR 202,88
EUR 105,00 spedizioneSpedito da Germania a U.S.A.Quantità: 1 disponibili
Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 1455 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.
Editore: Springer 1985
- Rilegato
Da: mountain, GEORGETOWN, CO, U.S.A.mountain
Contatta il venditoreVenditore con 5 stelleCondizione: Usato - Discreto
EUR 83,44
EUR 4,32 spedizioneSpedito in U.S.A.Quantità: 1 disponibili
hardcover. Condizione: Acceptable. Ex- Library no dust jacket medium wear to book edges and cover . Library stickers and stamps are present . Some corner dings.
Lingua: Inglese
Editore: Springer 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
- Print on Demand
Da: Brook Bookstore On Demand, Napoli, NA, ItaliaBrook Bookstore On Demand
Contatta il venditoreVenditore con 3 stelleCondizione: Nuovo
EUR 86,24
EUR 5,50 spedizioneSpedito da Italia a U.S.A.Quantità: Più di 20 disponibili
Condizione: new. Questo è un articolo print on demand.
Myeloid-Derived Suppressor Cells and Cancer
David Escors|James E. Talmadge|Karine Breckpot|Jo A. Van Ginderachter|Grazyna Kochan
Lingua: Inglese
Editore: Springer International Publishing 2016
Serie: SpringerBriefs in Immunology, Libro 4 di 9. Libro 4 di 9 - SpringerBriefs in Immunology
- Brossura
- Print on Demand
Da: moluna, Greven, , Germaniamoluna
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 48,37
EUR 48,99 spedizioneSpedito da Germania a U.S.A.Quantità: Più di 20 disponibili
Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Comprehensively explores the biology and role of MDSCs in cancerCovers therapeutic targeting via the STAT3 pathway, a major regulatory pathway in MDSCs functions as well as in tumour cellsPar…ticularly relevant for scientists working in the .
Lingua: Inglese
Editore: Springer US Apr 1985 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
- Print on Demand
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , GermaniaBuchWeltWeit Ludwig Meier e.K.
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 106,99
EUR 23,00 spedizioneSpedito da Germania a U.S.A.Quantità: 2 disponibili
Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations sti…mulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6). 212 pp. Englisch.
Lingua: Inglese
Editore: Springer US 1985
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Rilegato
- Print on Demand
Da: moluna, Greven, , Germaniamoluna
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 92,27
EUR 48,99 spedizioneSpedito da Germania a U.S.A.Quantità: Più di 20 disponibili
Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agen…ts. The initial observations stimulated a search fo.
Lingua: Inglese
Editore: Springer US 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
- Print on Demand
Da: moluna, Greven, , Germaniamoluna
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 92,27
EUR 48,99 spedizioneSpedito da Germania a U.S.A.Quantità: Più di 20 disponibili
Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemot…herapeutic agents. The initial observations stimulated a search fo.
Lingua: Inglese
Editore: Springer US Nov 2011 2011
Serie: Developments in Oncology, Libro 21 di 78. Libro 21 di 78 - Developments in Oncology
- Brossura
- Print on Demand
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, , GermaniaBuchWeltWeit Ludwig Meier e.K.
Contatta il venditoreVenditore con 5 stelleCondizione: Nuovo
EUR 139,05
EUR 23,00 spedizioneSpedito da Germania a U.S.A.Quantità: 2 disponibili
Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observati…ons stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for 'screening' drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6). 212 pp. Englisch.
