John m greally (40 risultati)

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Condizione: Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.…

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Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 456 | Sprache: Englisch | Produktart: Bücher | Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum. …

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Condizione: New. pp. 438.

Condizione: New. pp. 456.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.…

Hardcover. Condizione: Brand New. 1st edition. 438 pages. 9.25x6.25x0.75 inches. In Stock.

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.…

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Hardcover. Condizione: new. Hardcover. The concept of epigenetics is fascinating, confusing, and often misapplied. Yet it offers the tantalizing promise of explaining how cells with the same DNA acquire different identities and behaviors as they develop, how traits may possibly be passed through generations without changes to DNA sequence, and how environmental exposure may influence biological functions and ultimately human health.In this book's wide-ranging, iconoclastic exploration of the topic, John Greally traces the evolution of the concept of epigenetics from its historical roots in embryology to today's sprawling landscape of molecular definitions, genomic technologies, and disease hypotheses. He shows how epigenetics has captivated scientists, clinicians, and the public-and why caution is needed to avoid overinterpretation and pseudoscience.Written with clarity and authority, Epigenetics rejects simplistic answers and exaggerated claims to refocus the reader on what matters most: how cells establish and preserve identity and how this understanding translates into insights that are meaningful for human health.Essential reading for scientists, clinicians, students, and anyone curious about biology, this book is a guide to what epigenetics is, and is not. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.…

Buch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The concept of epigenetics is fascinating, confusing, and often misapplied. Yet it offers the tantalizing promise of explaining how cells with the same DNA acquire different identities and behaviors as they develop, how traits may possibly be passed through generations without changes to DNA sequence, and how environmental exposure may influence biological functions and ultimately human health.In this book's wide-ranging, iconoclastic exploration of the topic, John Greally traces the evolution of the concept of epigenetics from its historical roots in embryology to today's sprawling landscape of molecular definitions, genomic technologies, and disease hypotheses. He shows how epigenetics has captivated scientists, clinicians, and the public-and why caution is needed to avoid overinterpretation and pseudoscience.Written with clarity and authority, Epigenetics rejects simplistic answers and exaggerated claims to refocus the reader on what matters most: how cells establish and preserve identity and how this understanding translates into insights that are meaningful for human health.Essential reading for scientists, clinicians, students, and anyone curious about biology, this book is a guide to what epigenetics is, and is not.…

Condizione: new. Questo è un articolo print on demand.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Epigenomics tells us how the genome worksCharacterising the epigenome is the next big step after determining the sequence of the genomeEpigenetic influences are major causes of diseaseThe epigenome is dynamic and can change in respon.…