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gebundene Ausgabe. Condizione: Gut. XXVIII, 410 Seiten; Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber und kann entsprechende Merkmale aufweisen (Rückenschild, Instituts-Stempel.). In ENGLISCHER Sprache. Sprache: Englisch Gewicht in Gramm: 765.

Condizione: Good. *Price HAS BEEN REDUCED by 10% until Monday, May 18 (weekend sale item)* 401 pp., Hardcover, ex library, else text clean and binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.

Condizione: New. In.

Paperback. Condizione: Brand New. reprint edition. 429 pages. 9.00x1.00x6.30 inches. In Stock.

Hardcover. Condizione: gut. 2000. This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates. TOC: I: HIV Protease Inhibitors (PI).- II: Other Viral (Non-HIV) Protease Inhibitors.- III: (Non-Viral) Proteases Involved in Diseases. Reihe/Serie Handbook of Experimental Pharmacology ; Vol.140 Sprache englisch Maße 155 x 235 mm Einbandart gebunden Medizin Pharmazie Pharmakologie Arzneien Medikamente Arzneimittel Chemotherapie Chemotherapy drug design Pharmakologe Protease protease inhibitors Proteasen ISBN-10 3-540-66118-2 / 3540661182 ISBN-13 978-3-540-66118-4 / 9783540661184 In englischer Sprache. 401 pages. 24,1 x 15,9 x 2,5 cm.

Condizione: New. In.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Proteolytic enzymes and their natural antagonists, the protease inhibitor pro teins, play a crucial role in the physiology and pathology of living organisms including humans. Remark able advantages revealed their wide functional context. Proteases digest food proteinase in the digestive tract and liberate poly peptide hormones, stimulating gastric and pancreatic secretion. Proteases are involved during fertilization in sperm - egg interaction, ovulation, ovum implantation and parturition. Proteases of the renin-angiotensin and kallikrein-kinin systems act synergistically to generate blood pressure regu lating polypeptides. In wound healing a battery of proteases is involved in the proteolytic cascades of clotting, fibrinolysis and tissue repair.Another battery of very different proteases directs the immune defense via several routes, i.e. complement activation, antigen presentation, the generation of chemokines and chemotaxins directing phagocytes to the site of injury or infection and the generation of cell-stimulating factors such as cytokines regulating the inflam matory response of the organism.Granzymes contribute to the toxicity of lym phocytes or killer cells,caspases regulate physiological cell death and calpains intracellular signaling cascades.The energy-dependent proteasome-ubiquitin system controls highly efficientl y the activity or level of intracellular proteins, including cell-cycle regulators, transcription and signal transduction factors, oncoproteins and short-lived metabolic enzymes.And this listing is far from complete.

Taschenbuch. Condizione: Neu. Proteases as Targets for Therapy | Klaus Helm (u. a.) | Taschenbuch | xxviii | Englisch | 2012 | Springer | EAN 9783642630231 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Paperback. Condizione: Like New. Like New. book.

Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 410 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

Hardcover. Condizione: Brand New. 410 pages. 9.50x6.25x1.00 inches. In Stock.

Condizione: New. This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathologica.

Condizione: new. Questo è un articolo print on demand.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proteolytic enzymes and their natural antagonists, the protease inhibitor pro teins, play a crucial role in the physiology and pathology of living organisms including humans. Remark able advantages revealed their wide functional context. Proteases digest food proteinase in the digestive tract and liberate poly peptide hormones, stimulating gastric and pancreatic secretion. Proteases are involved during fertilization in sperm - egg interaction, ovulation, ovum implantation and parturition. Proteases of the renin-angiotensin and kallikrein-kinin systems act synergistically to generate blood pressure regu lating polypeptides. In wound healing a battery of proteases is involved in the proteolytic cascades of clotting, fibrinolysis and tissue repair.Another battery of very different proteases directs the immune defense via several routes, i.e. complement activation, antigen presentation, the generation of chemokines and chemotaxins directing phagocytes to the site of injury or infection and the generation of cell-stimulating factors such as cytokines regulating the inflam matory response of the organism.Granzymes contribute to the toxicity of lym phocytes or killer cells,caspases regulate physiological cell death and calpains intracellular signaling cascades.The energy-dependent proteasome-ubiquitin system controls highly efficientl y the activity or level of intracellular proteins, including cell-cycle regulators, transcription and signal transduction factors, oncoproteins and short-lived metabolic enzymes.And this listing is far from complete. 440 pp. Englisch.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. With contributions by numerous expertsSection I. Human Immunodeficiency Virus Protease Inhibitors.- 1 The Road to Fortovase. A History of Saquinavir, the First Human Immunodeficiency Virus Protease Inhibitor.- 2 Clinical Experience with Human Immunodefi.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Section I. Human Immunodeficiency Virus Protease Inhibitors.- 1 The Road to Fortovase. A History of Saquinavir, the First Human Immunodeficiency Virus Protease Inhibitor.- 2 Clinical Experience with Human Immunodeficiency Virus Protease Inhibitors: Antiretroviral Results, Questions and Future Strategies.- 3 The Nature of Resistance to Human Immunodeficiency Virus Type-1 Protease Inhibitors.- 4 The Next Generation of Human Immunodeficiency Virus Protease Inhibitors: Targeting Viral Resistance.- Section II. Other Viral (Non-HIV) Protease Inhibitors.- 5 The Proteinases Encoded by Hepatitis C Virus as Therapeutic Targets.- 6 The Human Herpes-Virus Proteases.- 7 The 3C Proteinases of Picornaviruses and Other Positive-Sense, Single-Stranded RNA Viruses.- 8 Adenovirus Proteinase-Antiviral Target for Triple-Combination Therapy on a Single Enzyme: Potential Inhibitor-Binding Sites.- 9 Proteinases as Virulence Factors in Bacterial Diseases and as Potential Targets for Therapeutic Intervention with Proteinase Inhibitors.- 10 Parasite Proteases as Targets for Therapy.- Section III. (Non-Viral) Proteases Involved in Diseases.- 11 Host Proteinases as Targets for Therapeutic Intervention.- 12 The Role of Metalloprotease Inhibitors in Cancer and Chronic Inflammatory Diseases.- 13 The Tumor Necrosis Factor- Converting Enzyme.- 14 Serine Elastases in Inflammatory and Vascular Diseases.- 15 Inhibitors of Thrombin and Factor Xa.- 16 Inhibitors of Papain-Like Cysteine Peptidases in Cancer.- 17 Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis.- 18 Proteasome and Apoptosis.- 19 Proteolytic Processing of the Amyloid Precursor Protein of Alzheimer's Disease.- 20 Presenilins and -Amyloid Precursor Protein-Proteolytically Processed Proteins Involved inthe Generation of Alzheimer's Amyloid Peptide.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 440 pp. Englisch.