Kovpak vitaly (9 risultati)

Condizione: New.

Condizione: New.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientific Study from the year 2020 in the subject Veterinary medicine, grade: 10, , language: English, abstract: This study investigates the changes in the pancreas of rats with the introduction of alloxan, confirming histologically the presence of pathological processes characteristic of type I diabetes. Additionally, a cytogenetic analysis of rat cells in culture obtained from red bone marrow, adipose tissue and pancreas during subcultivation in the in vitro system was performed and their phenotypic characterization was given. Furthermore the histological changes in the pancreas of rats were analysed with the introduction of cell cultures obtained from different sources against experimental diabetes and studied the changes in the blood glucose of experimental animals with the transplantation of cellular material.Despite the shortcomings of the modern methods of treating animals with type I diabetes using insulin therapy, as well as the fact that pancreatic beta-cell death is one of the important elements in the diabetes pathogenesis, new approaches to the treatment of this disease using cell technologies are being studied. Recent studies of beta-cells in the in vitro system have shown that they have a fairly high regenerative capacity, but in the in vivo system with diabetes, these cells almost do not recover. The development of methods that can activate beta-cell regeneration is an important area of the scientific research.To date, mainly red bone marrow is used as the source of stem cells for research, because this is the only tissue of the adult body that normally contains immature, undifferentiated and low-differentiated cells. However, adipose tissue is being increasingly used as an alternative source for stem cells, from which they can be isolated in significantly larger quantities using less invasive methods compared to using red bone marrow. It is worth noting that there are still a lot of unclear issues in the study of the pancreas regeneration ways, therefore, in the treatment of patients with diabetes, the direction of the use of cell culture obtained from the pancreas is especially relevant. Given the above, the aim of our study was to study the effect of cell cultures obtained from adipose tissue, bone marrow, and pancreas on the course of experimentally formed insulin-dependent type I diabetes in rats with the aim of developing scientifically based and effective cell therapy methods in veterinary medicine. 48 pp. Englisch.…

Condizione: New. Print on Demand.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientific Study from the year 2021 in the subject Veterinary medicine, , language: English, abstract: The research mainly focuses on the culture of myocardium-derived stem cells as an alternative source of the cell materials for treating patients with heart disease. Myocardial ischemia is a heart dysfunction caused by insufficient blood supply to its muscle tissue. This supply decrease can be related to the narrowing of coronary arteries, coronary thrombosis, or diffusive narrowing of arterioles and other small-sized vessels of the heart. Stopping the blood supply to the myocardium may lead to cardiac muscle necrosis (myocardial infarction).Coronary arteries perfuse the heart and help transport the nutrients and Oxygen to metabolically active myocardium. Nowadays, myocardial ischemia, which is associated with atherosclerosis and coronary arteries obstruction, is the leading cause of death for both men and women, and according to the predictions it will remain so until 2030. Myocardial ischemia and myocardial infarction, which is associated with coronary arteries diseases, can also happen to small animals like cats and dogs, which may lead to a sudden death or death while under anesthesia. Because the heart of adult mammals has extremely limited regeneration ability and the lost cells are replaced with fibrous scars, there is a need for search for treatment methods that are aimed at restoring the structure of cardiac muscle after the ischemia. Cell technologies are a promising treatment method for animals with myocardial infarction that restores its structure and contractile function. In the past 50 years there have been a significant number of experimental researches that deal with the cell technologies issues. As a result of the research, we understand that stem cells and their derivatives may lay foundation for developing the innovative cell technologies, at any stage of histogenesis. The spectrum of clinical issues that this kind of treatment methods is expected to help with is astounding.However, the introduction of cell technologies to the clinical practice requires a thorough guide for protocols on how to obtain the stem cells, cell culture and usage, deep study of recipient organism and the transplanted cells interaction, close control of phenotypic and genetic changes in order to provide high quality and safety of the used cell materials in restorative clinical therapy of post myocardial infarction changes in the myocardium. 88 pp. Englisch.…

Condizione: New. PRINT ON DEMAND.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Scientific Study from the year 2020 in the subject Veterinary medicine, grade: 10, , language: English, abstract: This study investigates the changes in the pancreas of rats with the introduction of alloxan, confirming histologically the presence of pathological processes characteristic of type I diabetes. Additionally, a cytogenetic analysis of rat cells in culture obtained from red bone marrow, adipose tissue and pancreas during subcultivation in the in vitro system was performed and their phenotypic characterization was given. Furthermore the histological changes in the pancreas of rats were analysed with the introduction of cell cultures obtained from different sources against experimental diabetes and studied the changes in the blood glucose of experimental animals with the transplantation of cellular material. Despite the shortcomings of the modern methods of treating animals with type I diabetes using insulin therapy, as well as the fact that pancreatic ¿-cell death is one of the important elements in the diabetes pathogenesis, new approaches to the treatment of this disease using cell technologies are being studied. Recent studies of ¿-cells in the in vitro system have shown that they have a fairly high regenerative capacity, but in the in vivo system with diabetes, these cells almost do not recover. The development of methods that can activate ¿-cell regeneration is an important area of the scientific research. To date, mainly red bone marrow is used as the source of stem cells for research, because this is the only tissue of the adult body that normally contains immature, undifferentiated and low-differentiated cells. However, adipose tissue is being increasingly used as an alternative source for stem cells, from which they can be isolated in significantly larger quantities using less invasive methods compared to using red bone marrow. It is worth noting that there are still a lot of unclear issues in the study of the pancreas regeneration ways, therefore, in the treatment of patients with diabetes, the direction of the use of cell culture obtained from the pancreas is especially relevant. Given the above, the aim of our study was to study the effect of cell cultures obtained from adipose tissue, bone marrow, and pancreas on the course of experimentally formed insulin-dependent type I diabetes in rats with the aim of developing scientifically based and effective cell therapy methods in veterinary medicine. 48 pp. Englisch.…

Taschenbuch. Condizione: Neu. The Effect of Allogenic Cell Cultures on Type I Diabetic Rats | Vitaly Kovpak (u. a.) | Taschenbuch | Englisch | 2021 | GRIN Verlag | EAN 9783346245441 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand. …

Taschenbuch. Condizione: Neu. Biological Properties of the Stem Cells and their Effect on Restoring Animal Myocardium after Experimental Ischemic Infarction | Vitaly Kovpak (u. a.) | Taschenbuch | Englisch | 2021 | GRIN Verlag | EAN 9783346474315 | Verantwortliche Person für die EU: GRIN Publishing GmbH, Waltherstr. 23, 80337 München, info[at]grin[dot]com | Anbieter: preigu Print on Demand.…