Lori j goldstein (25 risultati)
Lingua: Inglese
Editore: Kluwer, USA, 1994
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EUR 61,64
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Hardcover. Condizione: Very Good. 0792328361. Pharmaceutical company library hardcover, with minimal wear. 294 pages, index, illustrated with charts, tables and diagrams. Drug development has resulted in successful responses in childhood leukemia, testicular cancer and Hodgkin's disease. However, there are still many cancer-rela…ted deaths. Drug resistance is largely responsible for these failures and continues to be an area of active investigation. Drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, allowing us to explore the relationship between structure and function. In addition to clinical trials aimed at reversing MDR mediated drug resistance, gene therapy studies with MDR 1 gene retrovirally transduced into human bone marrow cells are described. MDR is the most understood mechanism of drug resistance, we are increasing our knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. Many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As understanding of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. Contents clean, tight and bright. Book.
Lingua: Inglese
Editore: Springer, 2012
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Da: California Books, Miami, FL, U.S.A.California Books
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EUR 235,41
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Condizione: New.
Lingua: Inglese
Editore: Springer, 1994
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Da: Ria Christie Collections, Uxbridge, Regno UnitoRia Christie Collections
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EUR 228,03
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Condizione: New. In.
Lingua: Inglese
Editore: Springer, 2012
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Da: Ria Christie Collections, Uxbridge, Regno UnitoRia Christie Collections
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Condizione: New. In.
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Lingua: Inglese
Editore: Humana, 2012
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Da: preigu, Osnabrück, Germaniapreigu
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EUR 184,95
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Taschenbuch. Condizione: Neu. Anticancer Drug Resistance | Advances in Molecular and Clinical Research | Lori J. Goldstein (u. a.) | Taschenbuch | xiii | Englisch | 2012 | Humana | EAN 9781461361299 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[do…t]com | Anbieter: preigu.
Lingua: Inglese
Editore: Springer, 1994
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Da: Bookmonger.Ltd, HILLSIDE, NJ, U.S.A.Bookmonger.Ltd
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EUR 282,28
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Hardcover. Condizione: Very Good.
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Lingua: Inglese
Editore: Springer, Humana, 2012
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Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
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EUR 223,11
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Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer…-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.
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Lingua: Inglese
Editore: Springer US, Springer US, 1994
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Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
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EUR 223,11
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Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-relate…d deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.
Lingua: Inglese
Editore: Springer, 2012
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Da: Books Puddle, New York, NY, U.S.A.Books Puddle
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EUR 312,88
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Condizione: New. pp. 312.
Lingua: Inglese
Editore: Springer, 2012
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Da: Revaluation Books, Exeter, Regno UnitoRevaluation Books
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EUR 306,51
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Paperback. Condizione: Brand New. reprint edition. 308 pages. 9.25x6.10x0.74 inches. In Stock.
Lingua: Inglese
Editore: Springer, 1994
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Da: Books Puddle, New York, NY, U.S.A.Books Puddle
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Condizione: New. pp. 312.
Anticancer Drug Resistance: Advances in Molecular and Clinical Research
Goldstein, Lori J. (Edited by)/ Ozols, Robert F. (Edited by)
Lingua: Inglese
Editore: Springer, 1994
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Da: Revaluation Books, Exeter, Regno UnitoRevaluation Books
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EUR 308,28
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Hardcover. Condizione: Brand New. 10.00x6.75x0.75 inches. In Stock.
Lingua: Inglese
Editore: Springer, 2012
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Da: Mispah books, Redhill, SURRE, Regno UnitoMispah books
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Paperback. Condizione: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.
Lingua: Inglese
Editore: Springer, 2012
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- Print on Demand
Da: Brook Bookstore On Demand, Napoli, NA, ItaliaBrook Bookstore On Demand
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EUR 166,29
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Condizione: new. Questo è un articolo print on demand.
- Altre immagini
Lingua: Inglese
Editore: Springer US, 2012
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Da: moluna, Greven, Germaniamoluna
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin s disease. We are still, however, conf…ronted with over 500,000 cancer-relate.
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Lingua: Inglese
Editore: Springer US, 1994
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Da: moluna, Greven, Germaniamoluna
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Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin s disease. We are still, how…ever, confronted with over 500,000 cancer-relate.
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Lingua: Inglese
Editore: Springer US Okt 2012, 2012
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.
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EUR 213,99
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with ove…r 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. 312 pp. Englisch.
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Lingua: Inglese
Editore: Springer US, 1994
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- Print on Demand
Da: preigu, Osnabrück, Germaniapreigu
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EUR 186,70
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Buch. Condizione: Neu. Anticancer Drug Resistance | Advances in Molecular and Clinical Research | Robert F. Ozols (u. a.) | Buch | Einband - fest (Hardcover) | Englisch | 1994 | Springer US | EAN 9780792328360 | Verantwortliche Person für die EU: Springer Heidelberg, Tiergartenstr. 17, 69121 Heidelberg, buchhandel-buch[at]spring…er[dot]com | Anbieter: preigu Print on Demand.
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Lingua: Inglese
Editore: Springer, Humana Okt 2012, 2012
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- Print on Demand
Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000
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EUR 213,99
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 50…0,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation.Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated.Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance.It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 312 pp. Englisch.
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Lingua: Inglese
Editore: Springer US, Springer US Dez 1994, 1994
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Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000
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EUR 213,99
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Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 c…ancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation.Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated.Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance.It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. 312 pp. Englisch.
Lingua: Inglese
Editore: Springer, 2012
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Da: Majestic Books, Hounslow, Regno UnitoMajestic Books
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EUR 330,85
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Condizione: New. Print on Demand pp. 312.
Lingua: Inglese
Editore: Springer, 1994
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Da: Majestic Books, Hounslow, Regno UnitoMajestic Books
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EUR 340,54
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Condizione: New. Print on Demand pp. 312.
Lingua: Inglese
Editore: Springer, 2012
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Da: Biblios, frankfurt am main, HESSE, GermaniaBiblios
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Condizione: New. PRINT ON DEMAND pp. 312.
Lingua: Inglese
Editore: Springer, 1994
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Da: Biblios, frankfurt am main, HESSE, GermaniaBiblios
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EUR 339,14
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Condizione: New. PRINT ON DEMAND pp. 312.
- Altre immagini
Lingua: Inglese
Editore: Springer US Dez 1994, 1994
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.
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EUR 373,43
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Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,0…00 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy. 312 pp. Englisch.
