Margaret m mccarthy (73 risultati)

Hard Cover. Condizione: Very Good. First Edition. a very good hardcover; an ex-library copy with usual markings; internally pages bright and clean; ---------- SATISFACTION GUARANTEED --------- FAST, COURTEOUS SERVICE ------ ALL ORDERS SHIPPED WITH DELIVERY CONFIRMATION; Size: 6 x 9". Ex-Library.

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Paperback or Softback. Condizione: New. Sex and the Developing Brain: Second Edition. Book.

Condizione: As New. Unread book in perfect condition.

Condizione: New.

Condizione: New.

Condizione: New.

Condizione: As New. Unread book in perfect condition.

Condizione: New.

Condizione: New. In English.

Condizione: As New. Unread book in perfect condition.

Paperback. Condizione: Brand New. 2nd edition. 139 pages. 9.00x7.25x0.25 inches. In Stock.

Condizione: New.

Soft cover. Condizione: New. 8vo (23.5 cm), XI, 139 pp. Laminated wrappers. Synopsis: The brains of males and females, men and women, are different, that is a fact. What is debated is how different and how important are those differences. Sex differences in the brain are determined by genetics, hormones, and experience, which in humans includes culture, society, and parental and peer expectations. The importance of nonbiological variables to sex differences in humans is paramount, making it difficult if not impossible to parse out those contributions that are truly biological. The study of animals provides us the opportunity to understand the magnitude and scope of biologically based sex differences in the brain, and understanding the cellular mechanisms provides us insight into novel sources of brain plasticity. Many sex differences are established during a developmental sensitive window by differences in the hormonal milieu of males versus females. The neonatal testis produces large amounts of testosterone which gains access to the brain and is further metabolized into active androgens and estrogens which modify brain development. Major parameters that are influenced by hormones include neurogenesis, cell death, neurochemical phenotype, axonal and dendritic growth, and synaptogenesis. Variance in these parameters results in sex differences in the size of particular brain regions, the projections between brain regions, and the number and type of synapses within particular brain regions. The cellular mechanisms are both region and endpoint specific and invoke many surprising systems such as prostaglandins, endocannabinoids, and cell death proteins. Epigenetic modifications to the genome both establish and maintain sex differences in the brain and behavior. By understanding when, why, and how sex differences in the brain are established, we may also learn the source of strong gender biases in the relative risk and severity of numerous neurological diseases and disorders of mental health. Boys are much more likely to be diagnosed with autism spectrum or attention and hyperactivity disorders, as well as speech and language deficits, compared to girls. By contrast, women are more likely to suffer from affective disorders, such as depression, anxiety, compulsion, and eating disorders and more likely to experience autoimmune and neurodegenerative disorders. Schizophrenia with an early onset is more common in males but a late-onset version is markedly more frequent in females. Male biased disorders have origins in development while female biased disorders are almost exclusively post-puberty. This remarkable shift in disease risk demands our attention. Novel insights into the biological origins of disease are also gained by comparing and contrasting the same processes in different sexes. …

Condizione: New.

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This open access book originates from the 36th Ernst Strüngmann Forum, where in 2023 scholars from a wide range of disciplines came together to advance understanding of gender, sex, and their entanglement. Although these interdisciplinary discussions revealed no single approach to the conceptualization or operationalization of sex/gender entanglement, they did uncover a high degree of convergence. Driving this project was the pressing need for constructive, interdisciplinary dialogue, as clearly articulated arguments grounded in rigorous, principled scholarship are required to promote sound application in research, policy, medicine, and public health.At the Forum, open debate is a given, but science does not operate in isolation from the political and social forces around it. This became starkly evident in 2025, when newly instituted policy interventions and measures impacted research and knowledge production in many areas of science, interfering not only with the first edition of this volume but, more broadly, affecting the lives of many individuals.The second edition seeks to redirect attention back to sound science. Together with updates throughout and a restored chapter on brain transcriptomics, this edition advances rigorous, interdisciplinary scholarship on sex/gender entanglement and illuminates viable paths forward.…

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Hardcover. Condizione: Brand New. 376 pages. 6.14x0.88x9.21 inches. In Stock.

Condizione: New. In English.

Hardcover. Condizione: Brand New. 2nd edition. 141 pages. 7.50x0.38x9.25 inches. In Stock.

Hardcover. Condizione: Very Good. Condizione sovraccoperta: Very Good. 2012 Cambridge University Press hadrcover edition. Light reading wear else very good condition. Bringing together a team of international scholars, this volume provides the first substantial text dedicated to the various contexts that frame Wharton's remarkable career. Each essay offers a clearly argued and lucid assessment of Wharton's work as it relates to seven key areas: life and works, critical receptions, book and publishing history, arts and aesthetics, social designs, time and place, and literary milieux. These sections provide a broad and accessible resource for students coming to Wharton for the first time while offering scholars new critical insights. CONTENTS: Part I. Life and Works 1. Edith Wharton: contextual revisions by Laura Rattray 2. Chronology: Wharton in cultural and historical context by Pamela Knights and Laura Rattray 3. Biography by Melanie Dawson 4. Composition and publication by Sharon Kehl Califano 5. Portraits of Wharton by Susan Goodman Part II. Critical Receptions 6. Contemporary reviews, 1877-1938 by Heidi M. Kunz 7. Obituaries by Linda De Roche 8. 'Justice' to Edith Wharton? The early critical responses by Melissa M. Pennell 9. Modern critical receptions by Jessica Schubert McCarthy Part III. Book and Publishing History 10. Wharton and her editors by Sharon Shaloo 11. Selling Wharton by Gary Totten 12. Serialization by Elsa Nettels 13. Short story markets by Bonnie Shannon McMullen Part IV. Arts and Aesthetics 14. Stage adaptations of Wharton's fiction by John Dennis Anderson 15. Wharton's writings on screen by Anne-Marie Evans 16. Visual arts by Emily J. Orlando 17. Architecture by Cecilia Macheski 18. Interior and garden design by Helena Chance 19. Images of Wharton by Katherine Joslin Part V. Social Designs 20. The marriage market by Pamela Knights 21. Leisured lives by Maureen E. Montgomery 22. Wharton and gender by Linda Wagner-Martin 23. Race and imperialism by Margaret Toth 24. Social transitions by Adam Jabbur Part VI. Time and Place 25. Wharton and France by William Blazek 26. Wharton and Italy by Robin Peel 27. Wharton and World War I by Julie Olin-Ammentorp 28. The 1920s by Gail D. Sinclair 29. Wharton and the Great Depression by Carol J. Singley Part VII. Literary Milieux 30. Literary influences by Judith P. Saunders 31. Wharton and the American romantics by Linda Costanzo Cahir 32. The novel of manners by Cecilia Macheski 33. Naturalism by Donna Campbell 34. Modernism by Jennifer Haytock.…

Paperback. Condizione: Brand New. 2nd edition. 776 pages. 10.00x8.25x1.50 inches. In Stock.

Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | The brains of males and females, men and women, are different, that is a fact. What is debated is how different and how important are those differences. Sex differences in the brain are determined by genetics, hormones, and experience, which in humans includes culture, society, and parental and peer expectations. The importance of nonbiological variables to sex differences in humans is paramount, making it difficult if not impossible to parse out those contributions that are truly biological. The study of animals provides us the opportunity to understand the magnitude and scope of biologically based sex differences in the brain, and understanding the cellular mechanisms provides us insight into novel sources of brain plasticity. Many sex differences are established during a developmental sensitive window by differences in the hormonal milieu of males versus females. The neonatal testis produces large amounts of testosterone which gains access to the brain and is further metabolized into active androgens and estrogens which modify brain development. Major parameters that are influenced by hormones include neurogenesis, cell death, neurochemical phenotype, axonal and dendritic growth, and synaptogenesis. Variance in these parameters results in sex differences in the size of particular brain regions, the projections between brain regions, and the number and type of synapses within particular brain regions. The cellular mechanisms are both region and endpoint specific and invoke many surprising systems such as prostaglandins, endocannabinoids, and cell death proteins. Epigenetic modifications to the genome both establish and maintain sex differences in the brain and behavior. By understanding when, why, and how sex differences in the brain are established, we may also learn the source of strong gender biases in the relative risk and severity of numerous neurological diseases and disorders of mental health. Boys are much more likely to be diagnosed with autism spectrum or attention and hyperactivity disorders, as well as speech and language deficits, compared to girls. By contrast, women are more likely to suffer from affective disorders, such as depression, anxiety, compulsion, and eating disorders and more likely to experience autoimmune and neurodegenerative disorders. Schizophrenia with an early onset is more common in males but a late-onset version is markedly more frequent in females. Male biased disorders have origins in development while female biased disorders are almost exclusively post-puberty. This remarkable shift in disease risk demands our attention. Novel insights into the biological origins of disease are also gained by comparing and contrasting the same processes in different sexes. …

Condizione: New. In English.

Condizione: New. In English.

Condizione: New. Application of antisense oligonucleotide technology in the nervous system stands apart, largely because of its enormous success. The source of this success remains a matter of some controversy. This work addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action. Editor(s): McCarthy, Margaret M. Series: Perspectives in Antisense Science. Num Pages: 172 pages, biography. BIC Classification: MJN; PSAN. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 234 x 156 x 12. Weight in Grams: 980. . 1998. Hardback. . . . .…

Taschenbuch. Condizione: Neu. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning | Margaret M. McCarthy | Taschenbuch | xi | Englisch | 2012 | Springer US | EAN 9781461372387 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

hardcover. Condizione: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features: experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors; the novel use of plasmids to express antisense RNA in the nervous system; the biodistribution and metabolism of antisense oligonucleotides in the nervous system; rapid and unusual effects; and non-specific effects.…