Nicolle charls (1 risultati)

Hardcover. Condizione: Very Good. First Edition; First Printing. Large 8vo 9" - 10" tall; 2 p.l. & 994 & 1 pages; Contemporary binding, red half morocco over marbled boards, five raised bands on the spine, title, date and volume number lettered directly in spine panels in gilt, top edges lightly marbled to match the marbled endpapers. Just a hint of light rubbing at the edges and corners; the binding is clean and handsome. 1910 was a particularly significant year for the Institut Pasteur's 'Annales' -- with contributions detailing progress in understanding and irradicating diseases and their agents, ever expanding understanding of how complex biological systems operate, and a renewal of the great Pasteur's determined examinations of human food: how and why various agents cooperate (or collide) to make or break what we eat and drink. There is a title singled out in Garrison-Morton: [G-M 5384] -- "Recherches experimentales sur le typhus exanthà matique" -- by Charles Nicolle. In what became a series of reports, Nicolle demonstrated the transmission of typhus by the body louse ('Pediculus corporis'). Nicolle produced the disease in monkeys and guinea-pigs by the injection of infected blood. This hugely significant work was finally given its recognition when the author was awarded the Nobel Prize in 1928. There is also an article by the co-founder of modern immunology, published two years after Ãlie Metchnikoff became the second of the scientists of the Institut Pasteur to be awarded the Nobel Prize: (E. Metchnikoff, 'Etudes sur la flore intestinale: Deuxieme memoire -- Poisons Intestinaux et scleroses' [pp. 755-70]). In 1908, Metchnikoff and Paul Ehrlich had been awarded the Nobel Prize in Physiology or Medicine "in recognition of their work on immunity." Metchnikoff, (whose name is also now transliterated as Ilya Ilyich Mechnikov) was born near Kharkov in 1845. After studies in Russia and Germany, he held academic appointments in Odessa and St. Petersburg, but left Russia in the 1880's as a reaction to political turbulence. Metchnikoff went to Paris seeking advice from Louis Pasteur, who responded by appointing Metchnikoff to a position as the Institut Pasteur, where Metchnikoff remained until his death in 1916. This paper shows a major aspect of Metchnikoff's final scientific hypothesis -- that human aging is caused by toxic bacteria in the gut and that lactic acid could prolong life. Based on this theory, he drank sour milk every day -- seeking to provide his system with potential life-lengthening properties of lactic acid bacteria (Lactobacillus delbrueckii subsp. bulgaricus). Probiotics, a major theme of twenty-first century medicine and biology, starts here. This 1910 volume also contains a paper of great importance to early advancements in combating poliomyelitis, by Constantin Levaditi and Karl Landsteiner, who demonstrated that poliomyelitis is due to a filterable virus -- (Etude experimentale de la Poliomyà lite aiguë,' pp. 833-878. [relates to G-M 4670.3]. Landesteiner had isolated the polio virus the previous year (working with Karl Popper). Levaditi continued working on poliomyelitis, following an outbreak in Sweden. Together with Carl Kling, Levanditi authored the first monograph dedicated to the disease, La Poliomyà lite aiguë à pidà mique (1913). In addition to a partiularly rich mix of the subjects to which the Insittut Pasteur has traditionally focused -- infectuous disease, rabies, serums and vaccination. there is an extensive series by Pierre Mazà on cheesemaking. ['Technique fromagà re' published in three parts, all contained in this 1910 volume -- see pp. 395; 435; and 543. The significance of these detailed accounts of the process by which milk becomes cheese was great at the time of publication, and may be greater now, just over a century later. While cheesemakers have, for centuries, assumed that the process they exploited was an example of spontaneous generation -- Louis Pasteur proved them wrong not quite fifty years before this voume appeared. Milk becomes cheese.…