P zambetti (34 risultati)

Condizione: New. pp. 260.

Condizione: New. pp. 260 Illus.

Condizione: New. pp. 260.

Condizione: quasi ottimo. Italia Centrale Local History Central Italy bross. edit. ill. - prima edizione - illustrazioni in b.n. fuori testo OTTIME CONDIZIONI.

Condizione: Very Good. 1st Edition. Former library copy. Pages intact with possible writing/highlighting. Binding strong with minor wear. Dust jackets/supplements may not be included. Includes library markings. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.…

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: New. New.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

Condizione: BUONO USATO. Da revisionare ITALIANO Piccolo volume di preghiere, con copertina in cartoncino flessibile, ingiallita, con evidente fioritura, macchie ed usura ai bordi, pagine lievemente ingiallite ai bordi rimanendo comunque in buonissimo stato di conservazione Numero Pagine 118.

Condizione: BUONO USATO. IED. Da revisionare ITALIANO Libro usato ma in buone condizioni. Potrebbe presentare piccolissimi danni alle copertine e lievi piegature da lettura al dorso e/o piegature minime agli angoli, normali segni del tempo. La rilegatura potrebbe essere minimamente allentata ma integra e senza fogli sciolti e o mancanze. Le pagine e/o i tagli potrebbero essere lievemente ingialliti con minima fioritura. La foto corrisponde al libro in vendita. Altre foto su richiesta. Numero pagine 185.…

Condizione: DISCRETO USATO. Da revisionare ITALIANO Copertina morbida illustrata e lievemente ingiallita dal tempo mostrante quasi impercettibili segni di usura da scaffale e leggere macchioline marroni ai piatti. Pagine minimamente ingiallite dal tempo con occasionali illustrazioni in bianco e nero. Numero pagine 69.…

Condizione: New.

Condizione: New.

Condizione: As New. Unread book in perfect condition.

Condizione: As New. Unread book in perfect condition.

Taschenbuch. Condizione: Neu. The p53 Tumor Suppressor Pathway and Cancer | Gerard P. Zambetti | Taschenbuch | Protein Reviews | x | Englisch | 2014 | Springer | EAN 9781489998798 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging eld rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the eld exploded and p53 became a major focus of scientists around the world.…

Buch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The p53 tumor suppressor gene is mutated in approximately half of all human malignancies, including colon, lung, and breast cancers. It is well recognized that these mutations directly inactivate p53 tumor suppressor function. Furthermore, the p53 protein operates within a pathway and this pathway, including the mutations in p53, is likely inactivated by nearly every human tumor. In support of this hypothesis, 100% of mice that have been engineered such that they do not express p53 protein (knockout animals), develop highly malignant tumors by only 3-6 months of age. The importance of p53 in preventing human cancer is also evident by families in which a mutated p53 gene is inherited from a parent. Individuals who carry an inherited germline p53 mutation are associated with Li-Fraumeni syndrome. These carriers often develop cancer as children or young adults (some have multiple tumors) and remarkably, 90% of these individuals will develop cancer by 60 years of age. Lastly, cigarette smoke, sexually transmitted viruses, and other environmental hazards play a significant role in the disruption of the p53 pathway. The p53 Tumor Suppressor Pathway and Cancer provides a comprehensive review of the p53 tumor suppressor pathway, how p53 functions to prevent tumor genesis, and how this pathway is corrupted during tumor development. The latest, state-of-the-art strategies to combat cancer by targeting p53 defects in tumors is also presented.…

Condizione: New. pp. 260.

Hardcover. Condizione: Brand New. 1st edition. 246 pages. 9.50x6.50x1.00 inches. In Stock.

121 S. OBr. Sprache: Deutsch.

Condizione: new. Questo è un articolo print on demand.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging eld rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the eld exploded and p53 became a major focus of scientists around the world. 260 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The p53 tumor suppressor gene is mutated in approximately half of all human malignancies, including colon, lung, and breast cancers. It is well recognized that these mutations directly inactivate p53 tumor suppressor function. Furthermore, the p53 protein operates within a pathway and this pathway, including the mutations in p53, is likely inactivated by nearly every human tumor. In support of this hypothesis, 100% of mice that have been engineered such that they do not express p53 protein (knockout animals), develop highly malignant tumors by only 3-6 months of age. The importance of p53 in preventing human cancer is also evident by families in which a mutated p53 gene is inherited from a parent. Individuals who carry an inherited germline p53 mutation are associated with Li-Fraumeni syndrome. These carriers often develop cancer as children or young adults (some have multiple tumors) and remarkably, 90% of these individuals will develop cancer by 60 years of age. Lastly, cigarette smoke, sexually transmitted viruses, and other environmental hazards play a significant role in the disruption of the p53 pathway. The p53 Tumor Suppressor Pathway and Cancer provides a comprehensive review of the p53 tumor suppressor pathway, how p53 functions to prevent tumor genesis, and how this pathway is corrupted during tumor development. The latest, state-of-the-art strategies to combat cancer by targeting p53 defects in tumors is also presented. 260 pp. Englisch.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides the best comprehensive summary of the most important studies&nbsp book regarding this fundamental tumor suppressorIf one wants to understand cancer, one must begin by studying p53Full color through-out textDr. Gerard Za.…

Gebunden. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides the best comprehensive summary of the most important studies&nbsp book regarding this fundamental tumor suppressorIf one wants to understand cancer, one must begin by studying p53Full color through-out textDr. Gerard Za.…