Raj sewduth (9 risultati)

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Taschenbuch. Condizione: Neu. Vascular Morphogenesis is regulated by Wnt signaling via PDZRN3 | Role of a novel ubiquitin ligase in Wnt signal transduction during development and in pathology | Raj Sewduth | Taschenbuch | 228 S. | Englisch | 2016 | SPS | EAN 9783639861167 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work presents the characterization Of the Ubiquitin Ligase PDZRN3 as a Novel Actor of Wnt Pathways in Vascular Morphogenesis and Integrity. Fzd4 is the only Frizzled receptor that is essential for angiogenesis. By using a yeast two hybrid screening, we have identified the ubiquitin ligase PDZRN3 as a potential partner of the adaptor protein Dvl3 that acts downstream of Fzd4. By using genetic models, we have shown that loss of PDZRN3 leads to early embryo lethality due to vascular defects in the yolk sac when deleted in utero, and is then required during retinal vascularization. PDZRN3 would target the Fzd4/ Dvl3 complex to endosome, leading to signal transduction upon binding of Wnt5a to Fzd4. PDZRN3 also regulates integrity of the blood brain barrier by acting on tight junctions stability. Loss of PDZRN3 stabilizes microvessels after cerebral ischemia. PDZRN3 would induce tight junction disruption and blood brain barrier leakage by ubiquitinylating the scaffolding protein MUPP1. 228 pp. Englisch.…

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This work presents the characterization Of the Ubiquitin Ligase PDZRN3 as a Novel Actor of Wnt Pathways in Vascular Morphogenesis and Integrity. Fzd4 is the only Frizzled receptor that is essential for angiogenesis. By using a yeast two hybrid screening, we have identified the ubiquitin ligase PDZRN3 as a potential partner of the adaptor protein Dvl3 that acts downstream of Fzd4. By using genetic models, we have shown that loss of PDZRN3 leads to early embryo lethality due to vascular defects in the yolk sac when deleted in utero, and is then required during retinal vascularization. PDZRN3 would target the Fzd4/ Dvl3 complex to endosome, leading to signal transduction upon binding of Wnt5a to Fzd4. PDZRN3 also regulates integrity of the blood brain barrier by acting on tight junctions stability. Loss of PDZRN3 stabilizes microvessels after cerebral ischemia. PDZRN3 would induce tight junction disruption and blood brain barrier leakage by ubiquitinylating the scaffolding protein MUPP1.…

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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This work presents the characterization Of the Ubiquitin Ligase PDZRN3 as a Novel Actor of Wnt Pathways in Vascular Morphogenesis and Integrity. Fzd4 is the only Frizzled receptor that is essential for angiogenesis. By using a yeast two hybrid screening, we have identified the ubiquitin ligase PDZRN3 as a potential partner of the adaptor protein Dvl3 that acts downstream of Fzd4. By using genetic models, we have shown that loss of PDZRN3 leads to early embryo lethality due to vascular defects in the yolk sac when deleted in utero, and is then required during retinal vascularization. PDZRN3 would target the Fzd4/ Dvl3 complex to endosome, leading to signal transduction upon binding of Wnt5a to Fzd4. PDZRN3 also regulates integrity of the blood brain barrier by acting on tight junctions stability. Loss of PDZRN3 stabilizes microvessels after cerebral ischemia. PDZRN3 would induce tight junction disruption and blood brain barrier leakage by ubiquitinylating the scaffolding protein MUPP1.OmniScriptum SRL, Str. Armeneasca 28/1, office 1, 2012 Chisinau 228 pp. Englisch.…