Ryan rautenbach (4 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Industrial-scale bioreactors expose cells to complex and continuously changing hydrodynamic conditions that are difficult to reproduce at laboratory scale. Conventional scale-down approaches are often developed under single-phase conditions and evaluated primarily using mixing times.This work combines experiments and validated Lattice-Boltzmann Large-Eddy Simulations to characterise the multiphase hydrodynamics of a 15 m mammalian cell culture stirred tank reactor. A Lagrangian, cell-centred perspective is used to quantify the conditions experienced by cells through velocity distributions, circulation times, residence times, and lifelines. Finite-Time Lyapunov Exponent fields additionally reveal coherent flow structures and transport barriers.The methodology is applied to evaluate the Single Multi-Compartment Bioreactor as a representative scale-down system. The results show that similarity achieved under single-phase conditions does not necessarily persist during aeration, highlighting the need to incorporate multiphase lifeline metrics into scale-down development and evaluation. 142 pp. Englisch.…

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Industrial-scale bioreactors expose cells to complex and continuously changing hydrodynamic conditions that are difficult to reproduce at laboratory scale. Conventional scale-down approaches are often developed under single-phase conditions and evaluated primarily using mixing times.This work combines experiments and validated Lattice-Boltzmann Large-Eddy Simulations to characterise the multiphase hydrodynamics of a 15 m mammalian cell culture stirred tank reactor. A Lagrangian, cell-centred perspective is used to quantify the conditions experienced by cells through velocity distributions, circulation times, residence times, and lifelines. Finite-Time Lyapunov Exponent fields additionally reveal coherent flow structures and transport barriers.The methodology is applied to evaluate the Single Multi-Compartment Bioreactor as a representative scale-down system. The results show that similarity achieved under single-phase conditions does not necessarily persist during aeration, highlighting the need to incorporate multiphase lifeline metrics into scale-down development and evaluation.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Industrial-scale bioreactors expose cells to complex and continuously changing hydrodynamic conditions that are difficult to reproduce at laboratory scale. Conventional scale-down approaches are often developed under single-phase conditions and evaluated primarily using mixing times.This work combines experiments and validated Lattice-Boltzmann Large-Eddy Simulations to characterise the multiphase hydrodynamics of a 15 m mammalian cell culture stirred tank reactor. A Lagrangian, cell-centred perspective is used to quantify the conditions experienced by cells through velocity distributions, circulation times, residence times, and lifelines. Finite-Time Lyapunov Exponent fields additionally reveal coherent flow structures and transport barriers.The methodology is applied to evaluate the Single Multi-Compartment Bioreactor as a representative scale-down system. The results show that similarity achieved under single-phase conditions does not necessarily persist during aeration, highlighting the need to incorporate multiphase lifeline metrics into scale-down development and evaluation. 142 pp. Englisch.…

Taschenbuch. Condizione: Neu. Lagrangian-Based Characterisation of Aerated Stirred Tank Reactors | Ryan Rautenbach | Taschenbuch | Berichte aus dem Institut für Mehrphasenströmungen 18 | Englisch | 2026 | Cuvillier | EAN 9783689525781 | Verantwortliche Person für die EU: Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen, info[at]cuvillier[dot]de | Anbieter: preigu Print on Demand. …