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Da: BargainBookStores, Grand Rapids, MI, U.S.A.
Paperback or Softback. Condizione: New. Zoledronic Acid Inhibits Cancer Growth. Book.
EUR 50,19
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Aggiungi al carrelloCondizione: As New. Unread book in perfect condition.
Da: Ria Christie Collections, Uxbridge, Regno Unito
EUR 47,40
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Aggiungi al carrelloCondizione: New. In.
Lingua: Inglese
Editore: VDM Verlag Dr. M�ller 2011-07-08, 2011
ISBN 10: 3639365445 ISBN 13: 9783639365443
Da: Chiron Media, Wallingford, Regno Unito
EUR 44,84
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Aggiungi al carrelloPaperback. Condizione: New.
EUR 47,39
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Aggiungi al carrelloCondizione: New.
EUR 53,67
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Da: preigu, Osnabrück, Germania
EUR 43,30
Quantità: 5 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. Zoledronic Acid Inhibits Cancer Growth | Molecular Characterization of Zoledronic acid Induced Growth Inhibition in Cancer | Shiv Kishor Singh (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2011 | VDM Verlag Dr. Müller | EAN 9783639365443 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 51,55
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 49,61
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Aggiungi al carrelloPAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Da: moluna, Greven, Germania
EUR 39,24
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Aggiungi al carrelloKartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh Dr.Shiv KishorFight Against Cancer: Once You Choose Hope, Anything s Possible.Autor/Autorin: Garima Singh Dr.Fight Against Cancer: Once You Choose Hope, Anything s Possible.Autor/Autorin: Dr. Volker Ellen.
Da: moluna, Greven, Germania
EUR 39,24
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Aggiungi al carrelloKartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh Dr. GarimaDarkness cannot drive out darkness, only light can do that. Cancer may have started the fight but research in cancer will finish it off one day.Autor/Autorin: Shiv Kishor Singh Dr.Darkness cannot drive ou.
Da: AHA-BUCH GmbH, Einbeck, Germania
EUR 49,95
Quantità: 2 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The aminobisphosphonate zoledronic acid(ZOL) has elicited significant attention due to its remarkable anti-tumoral activity,though its detailed mechanism of action remains unclear. Here,we demonstrate the existence of a nuclear GSK3-NFATc2 stabilization pathway that promotes cancer growth in vitro and in vivo and serves as a bonafide target of ZOL. Specifically, the serine/threonine kinase GSK3 stabilizes nuclear NFATc2 through phosphorylation of the serine-rich SP2 domain, thus protecting the transcription factor from E3-ubiquitin ligase HDM2 mediated proteolysis. ZOL disrupts this NFATc2 stabilization pathway through two mechanisms, namely GSK3 inhibition and induction of HDM2 activity. Upon nuclear accumulation,HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues K-684/K-897 and hence labels the factor for subsequent proteasomal degradation. Conversely, mutagenesis induced constitutive serine phosphorylation of the SP2 domain prevents NFATc2 from HDM2 mediated ubiquitination and degradation by ZOL. In conclusion, this report demonstrates a critical role of the GSK3-HDM2 signaling loop in the regulation of NFATc2 protein stability.