Singla yash paul (8 risultati)

Condizione: New.

Paperback. Condizione: Brand New. 128 pages. 8.66x5.91x0.29 inches. In Stock.

paperback. Condizione: New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -After the first decade of QSAR in mid 1970s, it was observed that relationship derived from a series of compounds investigated in isolated systems did not apply to in vivo situations. Hence, it was realized that ADME processes of a drug were important determinants, as these modulated the concentration-time profile of the drug substance at the drug receptor site. Indeed, lack of activity may not be due to low affinity of a drug for the receptor, but an inadequate concentration of the drug at these sites. The introduction of pharmacokinetic parameters permitted markedly better interpretation of the structure-activity correlation in physiological and biological terms. Development of QSPR amongst congeneric drug series not only saves considerable amount of time, money, animal life and involvement of 'normally, healthy and drug-free human volunteers' required for conducting experimental pharmacokinetic studies, but also the expertise of pharmacokinetists and drug designers. Therefore, this book may prove useful for those who want to explore such techniques for the determination of ADME properties of a chemical compound before being actually introducing into human volunteers. 128 pp. Englisch.…

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singla Yash PaulDr. Yash Paul Singla, M.Pharm., Ph.D is working as Professor of Pharmaceutics and Principal at Lord Shiva College of Pharmacy, Sirsa (Haryana) India. Till date he has guided 1 doctoral, 50 postgraduate research projec.…

Condizione: New. Print on Demand.

Condizione: New. PRINT ON DEMAND.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -After the first decade of QSAR in mid 1970s, it was observed that relationship derived from a series of compounds investigated in isolated systems did not apply to in vivo situations. Hence, it was realized that ADME processes of a drug were important determinants, as these modulated the concentration-time profile of the drug substance at the drug receptor site. Indeed, lack of activity may not be due to low affinity of a drug for the receptor, but an inadequate concentration of the drug at these sites. The introduction of pharmacokinetic parameters permitted markedly better interpretation of the structure-activity correlation in physiological and biological terms. Development of QSPR amongst congeneric drug series not only saves considerable amount of time, money, animal life and involvement of 'normally, healthy and drug-free human volunteers' required for conducting experimental pharmacokinetic studies, but also the expertise of pharmacokinetists and drug designers. Therefore, this book may prove useful for those who want to explore such techniques for the determination of ADME properties of a chemical compound before being actually introducing into human volunteers.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 128 pp. Englisch.…