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Soft cover. Condizione: New. New and lovely.

Hardcover. Condizione: Very Good. Condizione sovraccoperta: Very Good. 1st Edition. Book and dust jacket in very good condition.

Hardcover. Condizione: Very Good. Condizione sovraccoperta: Very Good. Signed by both editors and one contributor! DJ has edge wear, creases, minor scratches, rubbed corners/spine. Boards have edge wear, rubbed corners/spine. No writing in text. Very good. Signed by Author(s).

FIRST EDITION. Tall 8vo. xvii, 398 pp. Articles, photos, figs., index. Blue cloth, dust jacket; jacket extremities slightly rubbed, else fine. Ownership rubber stamp & signature of Norman Horowitz, California Institute of Technology. "In the dawn of molecular biology in the 1960s, his interest turned to gene expression, in particular the regulation of production of RNA from genes. Experiments in his laboratory in collaboration with his postdoctoral fellow Ru Chih C. Huang showed that histone, a protein associated with the genes, shuts off gene activity. If the histone fraction is extracted from isolated chromatin, more RNA is made whereas if histone is added back, the transcription of RNA is greatly decreased. In the course of these experiments, Huang and Bonner discovered DNA-dependent RNA polymerase, but Bonner noted in a biographical article that several other groups discovered the enzyme simultaneously." "Beginning about 1956 (at the urging of a former graduate student and by then postdoctoral fellow, Paul O. P. Ts'o), but with a significant acceleration in 1961, James became interested in protein synthesis, microsomal/chromosomal proteins, histones and chromatin (including non-histone chromosomal proteins) and molecular biology in general (including 3 papers on the molecular biology of memory!), nucleic acids, and the genome. This work encompassed about 190 publications with about 112 coauthors. James made numerous contributions in this area, far too many to discuss in limited space." "Paul O.P. Ts'o, who took his Ph.D. with James and by 1956 was a postdoctoral fellow, convinced James that they should study the most fundamental problem of biologyâ"how chromosomes control cellular metabolism." Frank B. Salisbury, "James Frederick Bonner, September 1, 1910â"September 13, 1996," National Academies of Sciences, Engineering, and Medicine. V. 73, 1998. Biographical Memoirs: Volume 73. Washington, DC: The National Academies Press.

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