Zhe sheng chen (158 risultati)

paperback. Condizione: New. Language:Chinese.Paperback. Pub Date: 2024-04 Publisher: Shanghai Culture Publishing House AI robot Hua Duoduo encountered difficulties in entering school. but was recognized for his bravery in saving people. However. three ruffians on campus bullied his classmates. and Hua Duoduo unfortunately disappeared. With wisdom and teamwork. the data detectives uncovered the truth. found the dark hacker and rescued Hua Duoduo. The exciting plot. the display of wisdom and teamwork. and the discussion o.…

paperback. Condizione: New. Language:Chinese.Paperback. Pub Date: 2024-04 Publisher: Shanghai Culture Publishing House This book revolves around a fake video case. Detectives use their superb skills to conduct in-depth investigations and uncover the truth behind fake videos. While reading. children will follow the footsteps of detectives to explore the mysteries of video fakery technology. and learn how to identify false information and protect their rights.…

paperback. Condizione: New. Language:Chinese.Paperback. Pub Date: 2024-04 Publisher: Shanghai Culture Publishing House Through the thrilling pursuit action. the book shows how detectives use wisdom and courage to uncover the true identity of the dark night hacker and maintain network security. While reading. children will understand the seriousness of network security issues and learn how to strengthen network security protection in daily life and protect their own information security.…

paperback. Condizione: New. Language:Chinese.Paperback. Pub Date: 2024-04 Publisher: Shanghai Culture Publishing House The book shows how detectives face difficulties and gradually uncover the secrets behind the Rubik's Cube Championship through exciting storylines. Children will feel the wisdom and courage of detectives while reading. and learn how to stick to dreams. face challenges. and move forward bravely in life.…

paperback. Condizione: New. Paperback. Pub Date: 2008 Pages: 109 Language: English Publisher: Zhejiang Science and Technology Press After nearly 30 years of reform and opening up development. especially in recent years. the construction of efficient ecological agriculture. Zhejiang Province. comprehensive agricultural production capacity greatly improved production and operation of a major shift in the way. are now at an important stage of development forward from traditional agriculture to modern agriculture. At the sa. …

paperback. Condizione: New. Language:Chinese.Publisher: China Children Publishing House Pub. Date :1999-08. Pages Number: 80 Publisher: China Children Publishing House Pub. Date :1999-08. Chinese Children s Encyclopedia is designed for primary school children in low-grade writing of. Of course. age. slightly smaller or bigger kids. you can still learn a lot from this book knowledge. This book is a book of this set of natural wonders volumes. has three characteristics: first. to young readers as the center. to observe. e. …

Hardcover. Condizione: Good. 1st Edition. Good+. Oversized hardcover, xxi + 270 pages, NOT ex-library. A corner crease to a portion of leaves. Interior is clean and bright throughout with unmarked text, free of inscriptions and stamps, firmly bound. Boards show rubbing and short creases to corners. Issued without a dust jacket. -- The book focuses on the use of protein kinase inhibitors (PKIs) to overcome multidrug resistance (MDR) in cancer treatment. Drawing from experimental and clinical research, it documents the biochemical, genetic, and molecular mechanisms by which PKIs sensitize tumors to chemotherapeutic agents. It offers 15 detailed review chapters, each addressing a distinct molecular target or signaling pathway, with implications for both solid and hematologic malignancies. The work serves as a reference for cancer researchers, oncologists, and clinicians designing or evaluating combinatory treatment strategies in the context of MDR. The introductory framework outlines the rationale for combining kinase inhibitors with chemotherapy. Resistance mechanisms - ranging from altered signal transduction to enhanced drug efflux via ATP-binding cassette (ABC) transporters - are central to treatment failure. The editors present kinase inhibitors as modulators that can reverse such resistance by targeting dysregulated pathways, thereby enhancing chemosensitivity and lowering effective drug doses. Chapters 1 through 4 focus on well-characterized tyrosine kinase pathways, beginning with EGFR and HER2, whose inhibitors (e.g., gefitinib, osimertinib) restore chemosensitivity in tumors with high ABC transporter activity. BCR-ABL inhibitors, such as imatinib, are examined for their dual role in chronic myeloid leukemia (CML) treatment and their regulatory effect on transporter expression. The VEGF/VEGFR axis and its blockade (e.g., with bevacizumab) is considered from an antiangiogenic perspective, while ALK inhibitors are reviewed for their ability to resensitize tumor cells through transporter modulation. Chapters 5-10 broaden the scope to include STAT3, FLT3, BTK, CDKs, and Bcl-2 - targets implicated in apoptosis evasion, aberrant cell cycling, and survival signaling. STAT3, though not yet clinically inhibited, is presented as a key future target due to its central role in oncogenesis. FLT3 inhibitors (e.g., midostaurin) are explored in acute myeloid leukemia, with attention to their impact on drug uptake and blood-brain barrier permeability. BTK inhibitors, particularly ibrutinib, are analyzed for their combination potential in hematologic malignancies. CDK inhibitors (e.g., palbociclib) and Bcl-2 antagonists are detailed in relation to phase-specific chemosensitization and apoptosis restoration. Chapters 11 to 15 cover kinase-related mechanisms and lesser-studied inhibitors, including Plk1, BRAF, and JAK modulators, which indirectly affect drug resistance via ABC transporter interactions. The PI3K/Akt pathway is reviewed in two chapters: first as a general resistance driver and target for sensitization, then in the broader context of mTOR and IGF signaling. These sections present the rationale for dual inhibition and review several trials combining these agents with cytotoxic therapies. The final chapter addresses MDM2/p53 interactions and their inhibition as a route to restoring tumor suppressor function, particularly in cancers with intact but suppressed p53 activity. Emphasis is placed throughout on mechanistic understanding as a prerequisite for therapeutic intervention. Each chapter includes summaries of preclinical data, clinical trials where available, and potential off-target effects. The book provides a modular yet comprehensive reference for designing synergistic cancer therapies involving kinase-targeted agents. It consolidates current targets and inhibitors with translational potential and contextualizes emerging therapies within molecular resistance frameworks to support evidence-based treatment decisions. …

paperback. Condizione: New. Language:Chinese.Paperback. Publisher: Ocean Press. If you are a girl. if you have a man chasing behind. said: I love you. that is.

paperback. Condizione: New. Language:Chinese.Paperback. Pages Number: 0 Publisher: Ocean Press Pub. Date :2007-11-01. Nalan explorers with all their love and happiness of their own people dream of love . traveled the entire side of the world. Way through the numerous forces of evil battle. children involved in the pedicle honey. tiger tulips and many other forces soul disputes. in the fight to get their skills upgraded. and eventually with the help of friends to beat their own wisdom the forces of evil . . Contents.…

paperback. Condizione: New. Language:Chinese.Paperback.Pub Date:2024-07 Pages:306 Publisher:Chemical Industry This book is based on the current procurement law and bidding law of my country. and comprehensively explains the main legal basis. bid evaluation methods. working procedures and matters that should be paid attention to in the bid evaluation practice of the three major categories of procurement projects. goods and services. At the same time. each type of project is accompanied by corresponding bid evaluation cas.…

paperback. Condizione: New. Paperback. Pub Date: 2024-07 Pages: 276 Publisher: China Railway Publishing House Co. Ltd. This book. building upon a clear explanation of the relationship between natural language processing and artificial intelligence in its opening chapters. combines current mainstream and cutting-edge applications in the field of natural language processing to explain the practical application of related algorithms in nine practical application scenarios. including text feature extraction. language gener.…

Soft cover. Condizione: New. Language:Chinese.Author:MA CHEN HUI ZU XUE ZHE ZHANG ZUAN XU XIAN SHENG SHI LVE NU ER. WEN GUANG HUAI NIAN ZHANG XUE MING HA JI.Binding.Publisher:Ningxia People's Publishing House.

Soft cover. Condizione: New. Language:Chinese.Author:CHEN ZONG GUANG 1955 NIAN SHENG YU ZHE JIANG QING TIAN GAN SHOU SONG YANG LIANG ZHU .Binding.Publisher:Qinghai People's Publishing House.

paperback. Condizione: New. Language:Chinese.Paperback.Pub Date:2023-03 Publisher:Zhejiang University Press.

paperback. Condizione: New. Ship out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.Paperback. Pub Date :2003-01-01 Pages: 183 Publisher: People's Education Press title: the Dewey of education and democracy Price: 13.80 yuan Author: Cho Yee (Author) Chen Hansheng (translator). Hongguang Lei (translation by) Publisher: People's Education Publishing Date :2003-1-1ISBN: 9787107166839 Words: Pages: 183 Edition: 1 Binding: Paperback: 32 Editor's Summary \ n Dewey On education and democracy to the United States famous educator John Dewey theory on Democracy and Education. a comprehensive and systematic introduction and objective. in-depth assessment. brilliant exposition of its main ideas and arguments. \ N directory of the abstracts preambleFour Satisfaction guaranteed,or money back. …

Soft cover. Condizione: New. Language:Chinese.Author:SHENG ZHE CHEN LEI.Binding:Soft cover.Publisher:World Press; 2 (January 1, 2010).

Condizione: New.

Paperback. Condizione: new. Paperback. Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Condizione: As New. Unread book in perfect condition.

paperback. Condizione: Good. Ship out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.Paperback. Pub Date :2006-08 Pages: 432 Publisher: Central China Normal University Press sheet: 13.75 title page names. with handwritingFour Satisfaction guaranteed,or money back.…

paperback. Condizione: Good. Ship out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.Black Arrow (1984 edition printed collections)Four Satisfaction guaranteed,or money back.

paperback. Condizione: Good. Ship out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.The female [Tianzhijiao drama comic book 84 years 1 version 1 India]Four Satisfaction guaranteed,or money back.

Hardcover. Condizione: new. Hardcover. Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Condizione: As New. Unread book in perfect condition.

Condizione: New.

Condizione: As New. Unread book in perfect condition.

paperback. Condizione: New. Language:Chinese.Paperback. Pub Date: 2024-08 Publisher: Shuhai Publishing House.

Soft cover. Condizione: New. Language:Chinese.Author:CHEN WEN HUA ZHE JIANG SHENG JIAO YU TING ZHI CHENG JIAO JIAO YAN SHI.Binding:Soft cover.Publisher:Machine Press Pub. Date :2009-08-01.

Condizione: New.

Condizione: New. 2018. 1st Edition. hardcover. . . . . .