birkhäuser springer sep 2011 (48 risultati)

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These notes are based on lectures presented during the seminar on ' Asymptotic Statistics' held at SchloB Reisensburg, Gunzburg, May 29-June 5, 1988. They consist of two parts, the theory of asymptotic expansions in statistics and probabilistic aspects of the asymptotic distribution theory in nonparametric statistics. Our intention is to provide a comprehensive presentation of these two subjects, leading from elementary facts to the advanced theory and recent results. Prospects for further research are also included. We would like to thank all participants for their stimulating discussions and their interest in the subjects, which made lecturing very pleasant. Special thanks are due H. Zimmer for her excellent typing. We would also like to take this opportunity to to express our thanks to the Gesellschaft fur mathematische Forschung and to the Deutsche Mathematiker Vereinigung, especially to Professor G. Fischer, for the opportunity to present these lectures and to the Birkhauser Verlag for the publication of these lecture notes. R. Bhattacharya, M. Denker Part I: Asymptotic Expansions in Statistics Rabi Bhattacharya 11 1. CRAMER-EDGEWORTH EXPANSIONS Let Q be a probability measure on (IRk, B'), B' denoting the Borel sigmafield on IR'. Assume that the s - th absolute moment of Q is finite, (1.1) P. := J II x lis Q(dx) 00, for some integer s;::: 3, and that Q is normalized, (1.2) J x(i)Q(dx) = 0 (1 ~ i ~ k), J x(i)x(j)Q(dx) = Dij (1 ~ i,j ~ k). 122 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Functional Analysis is a comprehensive, 2-volume treatment of a subject lying at the core of modern analysis and mathemati- cal physics. The first volume reviews basic concepts such as the measure, the integral, Banach spaces, bounded operators and generalized functions. Volume II moves on to more ad- vanced topics including unbounded operators, spectral decomposition, expansion in generalized eigenvectors, rigged spaces, and partial differential operators. This text provides students of mathematics and physics with a clear introduction into the above concepts, with the theory well illustrated by a wealth of examples. Researchers will appreciate it as a useful reference manual. 293 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Research of discrete event systems is strongly motivated by applications in flex ible manufacturing, in traffic control and in concurrent and real-time software verification and design, just to mention a few important areas. Discrete event system theory is a promising and dynamically developing area of both control theory and computer science. Discrete event systems are systems with non-numerically-valued states, inputs, and outputs. The approaches to the modelling and control of these systems can be roughly divided into two groups. The first group is concerned with the automatic design of controllers from formal specifications of logical requirements. This re search owes much to the pioneering work of P.J. Ramadge and W.M. Wonham at the beginning of the eighties. The second group deals with the analysis and op timization of system throughput, waiting time, and other performance measures for discrete event systems. The present book contains selected papers presented at the Joint Workshop on Discrete Event Systems (WODES'92) held in Prague, Czechoslovakia, on Au gust 26-28, 1992 and organized by the Institute of Information Theory and Au tomation of the Czechoslovak Academy of Sciences, Prague, Czechoslovakia, by the Automatic Control Laboratory of the Swiss Federal Institute of Technology (ETH) , Zurich, Switzerland, and by the Department of Computing Science of the University of Groningen, Groningen, the Netherlands. 244 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -New methods for solving classical problems in the theory of nonlinear operator equations (solvability, multiple solutions, bifurcations, nonlinear resonance, potential methods, etc) are introduced and discussed. The general abstract theorems are illustrated by various applications to differential equations and boundary value problems. In particular, the problem on forced periodic oscillations is considered for equations arising in control theory. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is dedicated to A.C. Zaanen, one of the pioneers of functional analysis, and eminent expert in modern integration theory and the theory of vector lattices, on the occasion of his 80th birthday. The book opens with biographical notes, including Zaanen's curriculum vitae and list of publications. It contains a selection of original research papers which cover a broad spectrum of topics about operators and semigroups of operators on Banach lattices, analysis in function spaces and integration theory. Special attention is paid to the spectral theory of operators on Banach lattices; in particular, to the one of positive operators. Classes of integral operators arising in systems theory, optimization and best approximation problems, and evolution equations are also discussed. The book will appeal to a wide range of readers engaged in pure and applied mathematics. 324 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -New trends in free boundary problems and new mathematical tools together with broadening areas of applications have led to attempts at presenting the state of art of the field in a unified way. In this monograph we focus on formal models representing contact problems for elastic and elastoplastic plates and shells. New approaches open up new fields for research. For example, in crack theory a systematic treatment of mathematical modelling and optimization of problems with cracks is required. Similarly, sensitivity analysis of solutions to problems subjected to perturbations, which forms an important part of the problem solving process, is the source of many open questions. Two aspects of sensitivity analysis, namely the behaviour of solutions under deformations of the domain of integration and perturbations of surfaces seem to be particularly demanding in this context. On writing this book we aimed at providing the reader with a self-contained study of the mathematical modelling in mechanics. Much attention is given to modelling of typical constructions applied in many different areas. Plates and shallow shells which are widely used in the aerospace industry provide good exam ples. Allied optimization problems consist in finding the constructions which are of maximal strength (endurance) and satisfy some other requirements, ego weight limitations. Mathematical modelling of plates and shells always requires a reasonable compromise between two principal needs. One of them is the accuracy of the de scription of a physical phenomenon (as required by the principles of mechanics). 370 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs. 288 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The last twenty years have witnessed enormous efforts by the pharmaceutical industry in the search for new drugs for the treatment of asthma. During this time, as a result of the efforts of asthma researchers in many disciplines, there has been an unprecedented increase in our knowledge about asthma as a disease and about the pharmacology of the existing anti-asthma drugs. This increase in knowledge should have generated information from which directions for future anti-asthma drug research and development might be predicted. Thus, we felt it was timely to invite a group of leading international pharmacologists to meet together on the occasion of the Xth International Congress of Pharmacology, being held for the first time in Australia (in Sydney August 23- 28th, 1987), for a satellite meeting to discuss the topic 'New drugs for asthma'. The proceedings of this small workshop are presented in this book. The meeting was unique in that leading pharmacologists from most of the pharmaceutical companies involved in the development of anti-asthma drugs were present. All participants, whether from the industry or from academia, were active researchers involved in providing the animal data and in carrying out human pharmacological studies, on new anti asthma drugs. Although the proceedings have been subtitled into 'symptomatic' and 'prophylactic' anti-asthma drugs for the purposes of presentation, this is not meant to pinpoint the idea that we believe such clear cut differences necessarily exist. In fact, they may not exist. 328 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Entre Meeanique et Arehiteeture: e'est-a-dire, entre les proeedes teehniques qui, depuis des temps immemoriaux eonforment l'art et la scienee de la eonstruetion au developpement de la scienee physique et mathematique la plus generale et, peut-etre, la plus abstraite, subalternata tanturn geometriae et philosophiae naturalis, eomme le disait Tartaglia, bien que liee aux faits les plus farniliers: la statique et la meeanique des mareriaux et des struetures. Le theme qui nous eoneeme est done la relation entre la technique et la scienee dans son exemple le plus important, je crois, du point de vue historiographique mais aussi epistemologique: a savoir, la relation entre le savoir faire, qui se eonforme a la norme, en respeetant une determination et une eongruenee parfaites avee son objectif, et la theorie, qui eonfirme la norme et temoigne la neeessite de la determiner eongrfiment avec les lois de la nature. Avee une extreme perspieaeite, quelque peu offusquee par une frivolite erudite, l' Abbe Franeeseo Maria Franeesehinis, mathematieien et adepte de la philosophie des lurnieres, se peneha sur la question dans un bref traite qu'il publia a Padoue en 1808 sous 1 le titre Des Mathematiques appliquees , soutenant la nouvelle tendanee didaetique introduite a l'Universite de Padoue par l'ephemere Regne d'Italie. Simulant un eonflit entre plusieurs auteurs, Franeesehinis exposait une premiere these dans un Discours inaugural qu'il reeita peut-etre reellement en 1807, lorsqu'il devint titulaire de la Chaire de Mathematiques appliquees. 408 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is devoted to a new direction in linear algebra and operator theory that deals with the invariants of partially specified matrices and operators, and with the spectral analysis of their completions. The theory developed centers around two major problems concerning matrices of which part of the entries are given and the others are unspecified. The first is a classification problem and aims at a simplification of the given part with the help of admissible similarities. The results here may be seen as a far reaching generalization of the Jordan canonical form. The second problem is called the eigenvalue completion problem and asks to describe all possible eigenvalues and their multiplicities of the matrices which one obtains by filling in the unspecified entries. Both problems are also considered in an infinite dimensional operator framework. A large part of the book deals with applications to matrix theory and analysis, namely to stabilization problems in mathematical system theory, to problems of Wiener-Hopf factorization and interpolation for matrix polynomials and rational matrix functions, to the Kronecker structure theory of linear pencils, and to non everywhere defined operators. The eigenvalue completion problem has a natural associated inverse, which appears as a restriction problem. The analysis of these two problems is often simpler when a solution of the corresponding classification problem is available. 368 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes. 340 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume I provides an in-depth discussion of the most recent developments of crucical biosensor components. It concentrates on the interface between the analyte phase and the detector, namely, the implementation of novel recognition elements, including nucleic acids, and of leading-edge technology in the construction of responsive thin layers. Thus, the reader can obtain a foretaste of achievable future progress in the field. 300 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 46 of 'Progress in Drug Research' contains seven reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with endo genous sodium pump inhibition, with neurotransmitters involved in the central regulation of the cardiovascular system, with leukotrienes and development of novel anti-inflammatory agents, with antithrombotic stra tegies and drugs affecting the plasma fibrinogen levels, with natural ami noglycosides and polyamines and their effects in the mammalian orga nism, with the latest developments in antidepressant agents and with immunopharmacological and biochemical bases of Chinese herbal medi cine. These reviews provide valuable information on several new deve lopments in the complex domain of drug research. In the 37 years that PDR has existed, the Editor has enjoyed the valua ble help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series of monographs. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such publi cations. 332 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -thrombospondin-l may be encoded by a tumor suppressor gene. Dr. O'Reilly discusses angiostatin, an exciting recently discovered factor derived from the fibrinolytic proenzyme plasminogen that inhibits tumor angiogenesis, primary tumor growth, and formation of metastases. In addition to the soluble class of angiogenesis-regulatory factors discussed above, interactions of endothelial cells with components of the extracellular matrix and with other cell types are critical for proper formation of vessels. Drs. Grant and Kleinman discuss the role of laminin and other matrix molecules in regulation of capillary formation. Dr. van Hinsbergh and colleagues describe the role of fibrin and the fibrinolytic system in angiogenesis associated with wound repair. Cell surface mole cules that interact with the extracellular matrix have been implicated in the regulation of angiogenesis. Dr. Varner discusses some exciting new studies on the roles of specific vascular cell integrins (a /33 and a /3s) in mediating v v tumor angiogenesis and angiogenesis associated with wound healing. The pericyte, a vascular smooth muscle-like cell, exerts a powerful regulatory effect during the later stages of angiogenesis in which mature capillaries are formed. These mechanisms are discussed by Drs. Hirschi and D' Amore. With all the recent progress in the molecular biology of angiogenesis, the contribution of microenvironmental conditions such as hypoxia and pH to angiogenesis is often ignored. Drs. Rockwell and Knisely review this area of investigation and present studies of experimental tumor models. 448 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is based on two keywords: Bioradical and ESR. Bioradical is a newly coined word which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structure and function of bioradicals has been attrac ting growing attention in the field of biological science, and comprehensive investigations from many fields are helping to understand the real features of these species. ESR spectroscopy also has interdisciplinary features in that its techniques have been applied to many fields, ranging from physics to medicine. It was our hope, therefore, that this book would help to clarify many aspects of bioradicals and that significant progress would be achieved in combining basic research from many different fields. This book arises from the First International Conference on Bioradicals Detected by ESR Spectroscopy (ICBES), which was held in Yamagata, a city in the Yamagata Prefecture of Japan, in 1994. About 300 participants from 16 different countries attended this conference, and about 170 papers were presented. This book is a collection of contributions from the conference and also contains eleven chapters selected by the editorial board, based on sugges tions from the members of the international editorial board of ICBES. The Yamagata Technopolis Foundation is developing a biomedical technology for the 21st century based on life science fused with material and physical science. Based on such a techno logy, the Foundation plans to share its fruits all over the world. 352 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Table of Contents: D. Duffie: Martingales, Arbitrage, and Portfolio Choice J. Fröhlich: Mathematical Aspects of the Quantum Hall Effect M. Giaquinta: Analytic and Geometric Aspects of Variational Problems for Vector Valued Mappings U. Hamenstädt: Harmonic Measures for Leafwise Elliptic Operators Along Foliations M. Kontsevich: Feynman Diagrams and Low-Dimensional Topology S.B. Kuksin: KAM-Theory for Partial Differential Equations M. Laczkovich: Paradoxical Decompositions: A Survey of Recent Results J.-F. Le Gall: A Path-Valued Markov Process and its Connections with Partial Differential Equations I. Madsen: The Cyclotomic Trace in Algebraic K-Theory A.S. Merkurjev: Algebraic K-Theory and Galois Cohomology J. Nekovár: Values of L-Functions and p-Adic Cohomology Y.A. Neretin: Mantles, Trains and Representations of Infinite Dimensional Groups M.A. Nowak: The Evolutionary Dynamics of HIV Infections R. Piene: On the Enumeration of Algebraic Curves - from Circles to Instantons A. Quarteroni: Mathematical Aspects of Domain Decomposition Methods A. Schrijver: Paths in Graphs and Curves on Surfaces B. Silverman: Function Estimation and Functional Data Analysis V. Strassen: Algebra and Complexity P. Tukia: Generalizations of Fuchsian and Kleinian Groups C. Viterbo: Properties of Embedded Lagrange Manifolds D. Voiculescu: Alternative Entropies in Operator Algebras M. Wodzicki : Algebraic K-Theory and Functional Analysis D. Zagier: Values of Zeta Functions and Their Applications 513 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of the present book is to propose a new algebraic approach to the study of norm stability of operator sequences which arise, for example, via discretization of singular integral equations on composed curves. A wide variety of discretization methods, including quadrature rules and spline or wavelet approximations, is covered and studied from a unique point of view. The approach takes advantage of the fruitful interplay between approximation theory, concrete operator theory, and local Banach algebra techniques. The book is addressed to a wide audience, in particular to mathematicians working in operator theory and Banach algebras as well as to applied mathematicians and engineers interested in theoretical foundations of various methods in general use, particularly splines and wavelets. The exposition contains numerous examples and exercises. Students will find a large number of suggestions for their own investigations. 376 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents the proceedings of the Joint German-Israeli Workshop on linear one-dimensional singular integral equations, held in Tel Aviv from March 1-10, 1995. The volume contains a selection of papers in modern operator theory and its applications. The main topics of the workshop were symbol calculus, index formulas, projection and quadrature methods for Toeplitz and singular integral operators with different symbols, algebras generated by such operators and algebras generated by indempotents. The other topics discussed were inverse scattering problems for differential operators, distribution of zeros for orthogonal functions, factorization of matrix functions and calculation of norms. The book will be appreciated by a wide audience in the mathematical and engineering sciences. 328 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Why do hormone receptors arise An introduction.- The evolution of recognition.- Signal receivers and signal molecules.- Interrelation of hormone receptor evolution.- Conclusions.- Mechanisms of receptor-mediated transmembrane signaling.- Receptors, acceptors channels and the problem of transmembrane-signaling.- General mechanisms of transmembrane signaling.- Receptor dynamics and transmembrane signaling.- Receptor microclustering and cell activation.- Internalized receptor and cell activation.- Summary.- Insulin receptors: structure and function.- The molecular mechanism of insulin action.- The insulin receptor kinase.- Biochemical properties of the insulin receptor kinase.- Role of receptor phosphorylation in insulin action.- Structure-function relationship of the insulin receptor kinase.- Summary and conclusions.- Internalization of polypeptide hormones and receptor recycling.- Historical perspective.- Events at the cell surface (steps 1, 2 and 3).- Initial steps of endocytosis (steps 4 and 5).- Later steps of endocytosis (steps 6, 7 and 8).- Receptor recycling.- What determines the specificity of receptor-mediated endocytosis.- Biochemical features of receptor-mediated endocytosis.- Functional implications of receptor-mediated endocytosis.- Conclusions.- The nature and development of steroid hormone receptors.- Models of steroid hormone action.- Nuclear binding sites.- Development of steroid receptors: Ontogeny of estrogen receptors.- Receptor ontogeny and hormonal imprinting.- Receptor alterations during ontogenetic development.- Why is receptor adaptation necessary An approach based on information theory.- Experimental evidence for hormonal imprinting.- Polypeptide hormones.- Imprinting by related hormones; the disturbing effect of 'noise'.- Overlappingimprinting by steroid hormones.- Imprinting with acid type hormones.- The importance and sensitivity of imprinting.- Hormonal imprinting in cell lines.- Cell-cell transmission of hormonal imprinting.- Hormonal imprinting at enzyme level.- The mechanism of imprinting.- The four stages of the development of encoded adaptation-requiring dynamic systems in mammals.- Medicinal aspects of hormonal imprinting.- The spectal case of hormonal imprinting, the neonatal influence of sex.- Historical perspectives.- Environmental influences on sexual differentiation.- Genetic influences on sexual differentiation.- Hormonal influences on sexual differentiation.- Conclusions.- The mechanism of receptor development as implied by hormonal imprinting studies on unicellular organisms.- The role of the cell membrane in hormonal imprinting.- The role of second messengers in hormonal imprinting.- Impact of the inhibition of endocytosis, transcription and translation on hormonal imprinting.- Impact of hormone concentration and time factor on hormonal imprinting.- Which materials can induce imprinting.- Study of induced receptors in the Tetrahymena.- Receptor 'memory' in unicellular model systems.- Structural studies on membrane receptors of Tetrahymena.- Specificity of the hormone receptors of Tetrahymena.- The phylogeny of the endocrine system.- The scope of phylogeny.- Thyroidal phylogenesis.- The steroid ring system.- Peptide hormones.- Pathways of endocrine diversification.- Multiple sites and actions.- Invertebrates.- Challenging perspectives.- A new approach to the molecular evolution of hormones: the receptorial aspect.- The signal molecule potential of amino acids.- The signal molecule potential of oligopeptides.- Common origin and phylogenetic diversification of animal hormonalsystems.- The significance of the evolutionary history of hormones.- The approach of comparative physiology.- The common base of intercellular messenger substances in multicellular organisms.- The different evolutions of animal and plant hormonal systems.- Diversification of hormonal systems in multicellular animals.- The evolutionary history of neu.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 31 of 'Progress in Drug Research' contains 13 articles, a sub ject index, an index for all articles that have been published so far in this series of monographs, as well as an author and subject index for all 31 volumes. The reviews in this volume are particularly concerned with the therapy of helminth diseases, with pyramidinones as biody namic agents, and with quinolones which are of interest in the treat ment of infections. For a deeper understanding of the pharmacokinet ic actions of modem drugs, the articles on cooperative binding of drug molecules to DNA, on in vitro models for the study of antibiotic activi ties, on inhibitors of the renin-angiotensin system, on GAB A-drug in teractions, and on the mechanism of action of anxiolytic drugs provide a wealth offacts and new findings. The pharmacology of caffeine is re viewed from the viewpoint of its role in combination with other phy siologically active substances, and the chapter on high resolution nuc lear magnetic resonance spectroscopy demonstrates the importance of this method in the development of new drugs. Finally, the article on light and dark touches border problems of the therapy of psychic dis orders. With these contributions, the authors aim to summarize latest achieve ments in important and actual fields of drug research. Researchers who are actively engaged in the same or in similar fields of research are sure to benefit from these efforts. 532 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W. 336 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This study has two declared aims: it presents the theoretical basis for a provably ideal comparative process for relaxing flows (ICP) and jus tifies its application to jet and, in particular, rocket engines. This will be treated in two parts. Part I offers a status quo report on current calculation methods, and compiles and explains briefly the most important data on selected pro minent rocket engines. Starting from the phenomenology of the dynamical and physico-chemical conversion processes in the fuel-oxidizer fluid mixture and in the burned gases, the ideal thermodynamic comparative process is then derived - as a defined sequential change of states in the system. In order to render this comparative process readily under standable, it is first applied to an appropriate model gas using alge braic equations for all relevant parameters. This model gas undergoes energy conversion processes without forfeiting the simplicity of pre sentation typical of classical gas dynamics. Above all, examination of this model offers proof that it is generally impermissible to use, as is done in practice, the familiar isentropic equation for flow changes of state continuously propagated in flow tube theory. Elementary calculations immediately indicate essential attributes which are also typical for relaxing, multicomponent, one-phase systems, such as the significant 'pressure drop phenomenon' or the establishment of the steady mass flow rate as an 'eigenvalue' of the comparative pro cess. Their relevance to the RE theory is stressed.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 272 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 336 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 288 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -'Stress-Inducible Cellular Responses' are essential for survival of cells of all species under adverse conditions. At the molecular level this is ac complished by a number of essential proteins all of which are involved in various aspects of cellular homeostasis through protective or adaptive func tions. Interestingly, molecules such as heat shock proteins have properties as molecular chaperones and are involved in multiple stages of a protein biogenesis beginning with synthesis and involvement in the subsequent events of folding, translocation, and degradation. Heat shock proteins have a critical role to stabilize folding intermediates and to prevent protein aggregation. In addition, stress-proteins serve as targets for immune re sponses in immune homeostasis and during infections. The term Stress Response reflects the rapid growth and breadth of this field which includes the molecular and cellular response to drugs, UV irra diation, oxidative stress, and environmental toxins. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metall ic ion status such as ferritin and protein disulfide isomerases are also con sidered within the frame of stress proteins and represent a new and growing class of stress responses.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 512 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Angiogenesis and angiogenesis inhibition: An overview.- Significance of angiogenesis in human disease.- Role of the macrophage in angiogenesis-dependent diseases.- Angiogenesis in human gliomas: Prognostic and therapeutic implications.- Regulation of angiogenesis in malignant gliomas.- Lymphangiogenesis: Mechanisms, significance and clinical implications.- Angiogenesis as a biologic and prognostic indicator in human breast carcinoma.- Molecular mechanisms of angiogenesis regulation.- Control of angiogenesis by cytokines and growth factors.- Fibroblast growth factors as angiogenesis factors: New insights into their mechanism of action.- Regulation of angiogenesis by scatter factor.- Vascular endothelial growth factor: Basic biology and clinical implications.- Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine.- Angiogenesis inhibition.- Angiostatin: An endogenous inhibitor of angiogenesis and of tumor growth.- Thrombospondin as a regulator of angiogenesis.- Regulation of angiogenesis by cell-matrix cell-cell and other interactions.- Regulation of capillary formation by laminin and other components of the extracellular matrix.- Hypoxia and angiogenesis in experimental tumor models: Therapeutic implications.- The role of vascular cell integrins v 3 and v 5 in angiogenesis.- Role of fibrin and plasminogen activators in repair-associated angiogenesis: In vitro studies with human endothelial cells.- Tumor angiogenesis: Functional similarities with tumor invasion.- Control of angiogenesis by the pericyte: Molecular mechanisms and significance.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 448 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Why do hormone receptors arise An introduction.- The evolution of recognition.- Signal receivers and signal molecules.- Interrelation of hormone receptor evolution.- Conclusions.- Mechanisms of receptor-mediated transmembrane signaling.- Receptors, acceptors channels and the problem of transmembrane-signaling.- General mechanisms of transmembrane signaling.- Receptor dynamics and transmembrane signaling.- Receptor microclustering and cell activation.- Internalized receptor and cell activation.- Summary.- Insulin receptors: structure and function.- The molecular mechanism of insulin action.- The insulin receptor kinase.- Biochemical properties of the insulin receptor kinase.- Role of receptor phosphorylation in insulin action.- Structure-function relationship of the insulin receptor kinase.- Summary and conclusions.- Internalization of polypeptide hormones and receptor recycling.- Historical perspective.- Events at the cell surface (steps 1, 2 and 3).- Initial steps of endocytosis (steps 4 and 5).- Later steps of endocytosis (steps 6, 7 and 8).- Receptor recycling.- What determines the specificity of receptor-mediated endocytosis.- Biochemical features of receptor-mediated endocytosis.- Functional implications of receptor-mediated endocytosis.- Conclusions.- The nature and development of steroid hormone receptors.- Models of steroid hormone action.- Nuclear binding sites.- Development of steroid receptors: Ontogeny of estrogen receptors.- Receptor ontogeny and hormonal imprinting.- Receptor alterations during ontogenetic development.- Why is receptor adaptation necessary An approach based on information theory.- Experimental evidence for hormonal imprinting.- Polypeptide hormones.- Imprinting by related hormones; the disturbing effect of 'noise'.- Overlappingimprinting by steroid hormones.- Imprinting with acid type hormones.- The importance and sensitivity of imprinting.- Hormonal imprinting in cell lines.- Cell-cell transmission of hormonal imprinting.- Hormonal imprinting at enzyme level.- The mechanism of imprinting.- The four stages of the development of encoded adaptation-requiring dynamic systems in mammals.- Medicinal aspects of hormonal imprinting.- The spectal case of hormonal imprinting, the neonatal influence of sex.- Historical perspectives.- Environmental influences on sexual differentiation.- Genetic influences on sexual differentiation.- Hormonal influences on sexual differentiation.- Conclusions.- The mechanism of receptor development as implied by hormonal imprinting studies on unicellular organisms.- The role of the cell membrane in hormonal imprinting.- The role of second messengers in hormonal imprinting.- Impact of the inhibition of endocytosis, transcription and translation on hormonal imprinting.- Impact of hormone concentration and time factor on hormonal imprinting.- Which materials can induce imprinting.- Study of induced receptors in the Tetrahymena.- Receptor 'memory' in unicellular model systems.- Structural studies on membrane receptors of Tetrahymena.- Specificity of the hormone receptors of Tetrahymena.- The phylogeny of the endocrine system.- The scope of phylogeny.- Thyroidal phylogenesis.- The steroid ring system.- Peptide hormones.- Pathways of endocrine diversification.- Multiple sites and actions.- Invertebrates.- Challenging perspectives.- A new approach to the molecular evolution of hormones: the receptorial aspect.- The signal molecule potential of amino acids.- The signal molecule potential of oligopeptides.- Common origin and phylogenetic diversification of animal hormonalsystems.- The significance of the evolutionary history of hormones.- The approach of comparative physiology.- The common base of intercellular messenger substances in multicellular organisms.- The different evolutions of animal and plant hormonal systems.- Diversification of hormonal systems in multicellular animals.- The evolutionary history of neurose.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Volume 31 of 'Progress in Drug Research' contains 13 articles, a sub ject index, an index for all articles that have been published so far in this series of monographs, as well as an author and subject index for all 31 volumes. The reviews in this volume are particularly concerned with the therapy of helminth diseases, with pyramidinones as biody namic agents, and with quinolones which are of interest in the treat ment of infections. For a deeper understanding of the pharmacokinet ic actions of modem drugs, the articles on cooperative binding of drug molecules to DNA, on in vitro models for the study of antibiotic activi ties, on inhibitors of the renin-angiotensin system, on GAB A-drug in teractions, and on the mechanism of action of anxiolytic drugs provide a wealth offacts and new findings. The pharmacology of caffeine is re viewed from the viewpoint of its role in combination with other phy siologically active substances, and the chapter on high resolution nuc lear magnetic resonance spectroscopy demonstrates the importance of this method in the development of new drugs. Finally, the article on light and dark touches border problems of the therapy of psychic dis orders. With these contributions, the authors aim to summarize latest achieve ments in important and actual fields of drug research. Researchers who are actively engaged in the same or in similar fields of research are sure to benefit from these efforts.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 532 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Entre Meeanique et Arehiteeture: e'est-a-dire, entre les proeedes teehniques qui, depuis des temps immemoriaux eonforment l'art et la scienee de la eonstruetion au developpement de la scienee physique et mathematique la plus generale et, peut-etre, la plus abstraite, subalternata tanturn geometriae et philosophiae naturalis, eomme le disait Tartaglia, bien que liee aux faits les plus farniliers: la statique et la meeanique des mareriaux et des struetures. Le theme qui nous eoneeme est done la relation entre la technique et la scienee dans son exemple le plus important, je crois, du point de vue historiographique mais aussi epistemologique: a savoir, la relation entre le savoir faire, qui se eonforme a la norme, en respeetant une determination et une eongruenee parfaites avee son objectif, et la theorie, qui eonfirme la norme et temoigne la neeessite de la determiner eongrfiment avec les lois de la nature. Avee une extreme perspieaeite, quelque peu offusquee par une frivolite erudite, l' Abbe Franeeseo Maria Franeesehinis, mathematieien et adepte de la philosophie des lurnieres, se peneha sur la question dans un bref traite qu'il publia a Padoue en 1808 sous 1 le titre Des Mathematiques appliquees , soutenant la nouvelle tendanee didaetique introduite a l'Universite de Padoue par l'ephemere Regne d'Italie. Simulant un eonflit entre plusieurs auteurs, Franeesehinis exposait une premiere these dans un Discours inaugural qu'il reeita peut-etre reellement en 1807, lorsqu'il devint titulaire de la Chaire de Mathematiques appliquees.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 408 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Volume I provides an in-depth discussion of the most recent developments of crucical biosensor components. It concentrates on the interface between the analyte phase and the detector, namely, the implementation of novel recognition elements, including nucleic acids, and of leading-edge technology in the construction of responsive thin layers. Thus, the reader can obtain a foretaste of achievable future progress in the field.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 300 pp. Englisch.