Humana mai 2014 (36 risultati)

Buch. Condizione: Neu. Neuware -Thisbookcollects and synthesizes the latest thinking on the condition in its variety of cognitive and behavioral presentations, matched by a variety of clinical responses. Acknowledging the continuum of injury and the multi-stage nature of recovery, expert contributors review salient research data and offer clinical guidelines for the neuropsychologist working with TBI patients, detailing key areas of impairment, brief and comprehensive assessment methods and proven rehabilitation strategies. Taken together, these chapters provide a framework for best serving a wide range of TBI patients (including children, elders, and patients in multidisciplinary settings) and model treatment that is evidence-based and relevant. A sample of the topics featured in the Handbook: Bedside evaluations in TBI.Outcome assessment in TBI.Collaborating with family caregivers in the rehabilitation of persons with TBI.Behavioral assessment of acute neurobehavioral syndromes to inform treatment.Pediatric TBI: assessment, outcomes, intervention.Special issues with mild TBI in veterans and active duty service members.Expanding professional knowledge on a topic that continues to grow in importance, the Handbook on the Neuropsychology of Traumatic Brain Injury is a premier resource, not only for neuropsychologists but also for other professionals in cognitive care, and trainees entering the field. 436 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Mathematics of Finance has been a hot topic ever since the discovery of the Black-Scholes option pricing formulas in 1973. Unfortunately, there are very few undergraduate textbooks in this area. This book is specifically written for advanced undergraduate or beginning graduate students in mathematics, finance or economics. This book concentrates on discrete derivative pricing models, culminating in a careful and complete derivation of the Black-Scholes option pricing formulas as a limiting case of the Cox-Ross-Rubinstein discrete model.This second edition is a complete rewrite of the first edition with significant changes to the topic organization, thus making the book flow much more smoothly. Several topics have been expanded such as the discussions of options, including the history of options, and pricing nonattainable alternatives. In this edition the material on probability has been condensed into fewer chapters, and the material on the capital asset pricing model has been removed.The mathematics is not watered down, but it is appropriate for the intended audience. Previous knowledge of measure theory is not needed and only a small amount of linear algebra is required. All necessary probability theory is developed throughout the book on a 'need-to-know' basis. No background in finance is required, since the book contains a chapter on options. 304 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Mathematics of Finance has been a hot topic ever since the discovery of the Black-Scholes option pricing formulas in 1973. Unfortunately, there are very few undergraduate textbooks in this area. This book is specifically written for advanced undergraduate or beginning graduate students in mathematics, finance or economics. This book concentrates on discrete derivative pricing models, culminating in a careful and complete derivation of the Black-Scholes option pricing formulas as a limiting case of the Cox-Ross-Rubinstein discrete model.This second edition is a complete rewrite of the first edition with significant changes to the topic organization, thus making the book flow much more smoothly. Several topics have been expanded such as the discussions of options, including the history of options, and pricing nonattainable alternatives. In this edition the material on probability has been condensed into fewer chapters, and the material on the capital asset pricing model has been removed.The mathematics is not watered down, but it is appropriate for the intended audience. Previous knowledge of measure theory is not needed and only a small amount of linear algebra is required. All necessary probability theory is developed throughout the book on a 'need-to-know' basis. No background in finance is required, since the book contains a chapter on options.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 304 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 68 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cloud Computing Basics covers the main aspects of this fast moving technology so that both practitioners and students will be able to understand cloud computing. The author highlights the key aspects of this technology that a potential user might want to investigate before deciding to adopt this service. This book explains how cloud services can be used to augment existing services such as storage, backup and recovery. Addressing the details on how cloud security works and what the users must be prepared for when they move their data to the cloud. Also this book discusses how businesses could prepare for compliance with the laws as well as industry standards such as the Payment Card Industry.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 160 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This SpringerBrief explores the evacuation characteristics of children and their self-preservation capability during fire situations. An international survey among teachers from day-care centers and experts in child development indicates an age-limit at which pre-school children may be considered capable of evacuating a location without direct intervention by an instructor.The survey examines the ability of children to understand and follow simple instructions, walk on horizontal surfaces without physical support, and walk down stairs. It also studies how fire safety installations and fire drills differ between countries. A literature review and a presentation of the method applied are included.This data can be applied to evacuation procedures, building codes, and fire regulations. Determining Self-Preservation Capability in Pre-School Children is intended for practitioners as a tool for analyzing evacuation safety issues and developing methods removing potential hazards. Researchers working in a related field will also find the book valuable.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 60 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book discusses the opportunities offered by disruptive technologies to overcome the economical and physical limits currently faced by the electronics industry. It provides a new methodology for the fast evaluation of an emerging technology from an architectural prospective and discusses the implications from simple circuits to complex architectures. Several technologies are discussed, ranging from 3-D integration of devices (Phase Change Memories, Monolithic 3-D, Vertical NanoWires-based transistors) to dense 2-D arrangements (Double-Gate Carbon Nanotubes, Sublithographic Nanowires, Lithographic Crossbar arrangements). Novel architectural organizations, as well as the associated tools, are presented in order to explore this freshly opened design space. 204 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book gives a survey of astrophysics at the advanced undergraduate level, providing a physics-centred analysis of a broad range of astronomical systems. It originates from a two-semester course sequence at Rutgers University that is meant to appeal not only to astrophysics students but also more broadly to physics and engineering students. The organisation is driven more by physics than by astronomy; in other words, topics are first developed in physics and then applied to astronomical systems that can be investigated, rather than the other way around.The first half of the book focuses on gravity. The theme in this part of the book, as well as throughout astrophysics, is using motion to investigate mass. The goal of Chapters 2-11 is to develop a progressively richer understanding of gravity as it applies to objects ranging from planets and moons to galaxies and the universe as a whole. The second half uses other aspects of physics to address one of the bigquestions. While 'Why are we here ' lies beyond the realm of physics, a closely related question is within our reach: 'How did we get here ' The goal of Chapters 12-20 is to understand the physics behind the remarkable story of how the Universe, Earth and life were formed. This book assumes familiarity with vector calculus and introductory physics (mechanics, electromagnetism, gas physics and atomic physics); however, all of the physics topics are reviewed as they come up (and vital aspects of vector calculus are reviewed in the Appendix).Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 456 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases. 480 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Full-scale political change affects every level of a society, but perhaps nowhere as strikingly as in the areas of crime policy and law enforcement. Over the past two decades, the European nations that have moved from totalitarianism toward democracy have come to embody this trend, yet reliable sources on crime and law enforcement in these countries have not been readily accessible to the West.Representing viewpoints seldom available to outsiders, the contributors to Crime and Transition in Central and Eastern Europe analyze changes in criminal activities and crime control strategies in the region, explain the political background underlying these developments, and assess their long-term social impact. Experts from Slovenia, Hungary, Croatia, Serbia, the Czech Republic, Poland, Bosnia and Herzegovina discuss the politicization of crime, the ongoing paradoxes regarding civil liberties, and the future of crime policy in comparative and country-specific terms. Among the topics featured in the book: Crime and crime control in transitional countries, politics, the media, and public perception of crime, surveillance: from national security to private industry, penal policy and political change, emerging trends: economic and organized crime, human trafficking, juvenile delinquency, new perspectives on corruption in the region.With this fascinating insight, Crime and Transition in Central and Eastern Europe is a singular reference for researchers and policymakers in criminology and political science, and historians with a special interest in European affairs and policy.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 308 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Economic growth of a country depends on its industries. The focus of modern growth theory is basically macroeconomics, although neoclassical models use competitive markets and the optimization behavior of households and firms in general equilibrium framework. The emphasis here is on industry growth, where the microfoundations of industry are analyzed in terms of economic efficiency. The various linkages which link firm growth with the industry growth are discerned here under various market structures both competitive and monopolistic. The role of information in facilitating market signals and allowing the adoption of new processes has been especially emphasized in this volume. Many issues of market failure and the suboptimality of competitive equilibria are due to incomplete and imperfect information structures and we need a comprehensive theory of information structures underlying the process of industry growth and its dynamics. This book will be of interest to economists studying economic and industry growth and innovation.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 188 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Yeast Protocols, Third Edition presents up-to-date advances in research using yeasts as models. Chapters cover topics such as basic protocols in yeast culture and genomic manipulation, protocols that study certain organelles such as mitochondria and peroxisomes and their functions in autophagy and assays commonly used in yeast-based studies that can be adapted to other organisms. As the first sequenced living organism, budding yeast S. cerevisiae and other model yeasts have helped greatly in life science research. The easy switch between the haploid and diploid state makes yeast a paradigm of genetic manipulation. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Yeast Protocols, Third Edition seeks to serve both professionals and novices with newly-developed protocols to study this essential model organism.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 324 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Exploring these type II trans-membrane proteins, The TNF Superfamily: Methods and Protocols focuses on various techniques to investigate aspects of the TNF Superfamily members in health and disease. Opening with protocols to understand the signaling process of TNF family members, this detailed volume continues with technical examples of investigating the role of TNF family members in physiopathologies, protocols on modulation of TNF signaling by pathogens, experimental applications of TNF-reporter mice, as well as methodologies for various assays of TNF family members and the production of recombinant molecules. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Practical and ready to use, The TNF Superfamily: Methods and Protocols will aid researchers investigating this key family of proteins, involved in vital processes such as providing signals for activation, differentiation, survival and death of cells, modulation of immune response and inflammation, hematopoiesis and osteoclastogenesis.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 240 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Engineering Multicellular Systems: Methods and Protocols, focuses on laboratory procedures used in recent efforts for constructing synthetic multicellular systems and their applications. In particular, constructing multicellular systems to form various microbial ecosystems has been extensively explored to examine evolution and interactions of microbial ecosystems, while co-cultures have emerged as an efficient tool to produce some complex chemical molecules. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.Engineering Multicellular Systems: Methods and Protocols provide a comprehensive laboratory protocol reference for constructing multicellular systems for various applications.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 268 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cancer Cell Signaling: Methods and Protocols, Second Edition brings together the most recent advances in cancer cell signaling knowledge along with recent progress in the development of novel strategies and experimental cell models to study human cancer. Opening with a section on targeting cancer cell metabolism as an anticancer strategy, this detailed volume continues with parts describing protocols to study epigenetic control of cancer, protocols to study cancer metastasis, as well as two new techniques for cancer study.Written for the highly successful Methods in Molecular Biology series, chapters include introductions for their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Second Edition is an ideal guide to the techniques that will aid researchers in exploiting our current knowledge in order to make a profound impact in cancer prevention and treatment.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 276 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book discusses the opportunities offered by disruptive technologies to overcome the economical and physical limits currently faced by the electronics industry. It provides a new methodology for the fast evaluation of an emerging technology from an architectural prospective and discusses the implications from simple circuits to complex architectures. Several technologies are discussed, ranging from 3-D integration of devices (Phase Change Memories, Monolithic 3-D, Vertical NanoWires-based transistors) to dense 2-D arrangements (Double-Gate Carbon Nanotubes, Sublithographic Nanowires, Lithographic Crossbar arrangements). Novel architectural organizations, as well as the associated tools, are presented in order to explore this freshly opened design space.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 204 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is written for ecologists interested in capturing their understandings of how natural systems work in software ¿ to help inform their work and communicate the consequences of proposed management plans. Historically, ecologists had to rely on the skills of trained computer programmers to modeling natural systems, but now a new generation of software is allowing ecologists to directly capture their understandings of systems in software. This book is a compilation of spatially explicit simulation models developed by ecologists and planners without any formal computer programming skills. Readers will be inspired to believe that they too can create similar models of the systems with which they are familiar.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 280 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Plant Cold Acclimation: Methods and Protocols details many of the methods and protocols commonly used to study plant cold acclimation and freezing tolerance, breeding, genetics, physiology or molecular biology, or any combination of these specialties. Chapters focus on interdisciplinary approaches, experimental methods, and concepts from different areas of science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Plant Cold Acclimation: Methods and Protocols seeks to help not only new researchers starting in this field, but also those already working in a particular area of cold acclimation and freezing tolerance research who are looking to expand their range of experimental approaches.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 296 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 480 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Plant Circadian Networks: Methods and Protocols provides a collection of protocols to investigate clock-controlled parameters including transcript and small RNA levels, promoter activity using luciferase reporters, protein levels and posttranslational modification, protein-protein interaction, in vivo DNA-protein interaction and RNA-protein interaction, cellular redox state, Ca2+ levels, and innate immune responses. Furthermore, the use of bioinformatics resources is described to evaluate high throughput data sets and to integrate the data into an overarching picture of circadian networks in the cell.Additional chapters focus on seasonal processes like flowering time control, and techniques on trees, moss and algae.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Plant Circadian Networks: Methods and Protocols is designed not only for the chronobiology community dealing with circadian biology but also for the plant community in general.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 376 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Listeria monocytogenes is still a major threat to public health. A new book in the Methods in Molecular Biology series, Listeria monocytogenes: Methods and Protocols addresses its titular pathogen with protocols and methodologies used in research to gain a better understanding of Listeria at a molecular level. The topics covered include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation and finally, methods for control of the organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Vital and authoritative, Listeria monocytogenes: Methods and Protocols aims to contribute to the harmonization of the methods used in the field and will therefore benefit all those interested in Listeria research.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 296 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine.This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine.Computational Biomechanics for Medicine: Deformation and Flow collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, andmedical robotics.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 148 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Providing a list of methods useful both to those who wish to study pseudogenes and to those who actually want to avoid their inadvertent detection, Pseudogenes: Functions and Protocols explores techniques involving pseudogenic DNA, RNA, and peptides/proteins, once believed to lack any functionality, but now known to be involved in complex regulatory circuits. After a few introductory chapters that overview the functions so far attributed to pseudogenes, this thorough volume delves into methods for pseudogene identification, for the detection of pseudogene transcription and translation, and for the study of the functions of pseudogenic RNA and proteins, as well as methods to avoid pseudogene detection when the focus of the research is their highly homologous parental counterparts. As part of the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed descriptions and implementation advice that ensures successful results in the lab.Authoritative and practical, Pseudogenes: Functions and Protocols will contribute to the high interest of the scientific community toward pseudogenes, while stimulating the conception of pseudogene - centered research projects and providing experimental protocols that can facilitate their execution.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 332 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -With rapid advancement in technology and materials in total knee arthroplasty (TKA), long-term survival and function of the total knee is now more and more dependent on restoring accurate limb alignment, precise component position and optimum soft-tissue balance. Proper technique is key to ensuring this andis all the more crucial and challenging to achieve in arthritic knees with severe and complex deformities. Correction of such knee deformities forms an important part of TKA for orthopedic surgeons working in both emerging and developed nations.Deformity Correction in Total Knee Arthroplasty fills the void that exists in treating severe and complex knee deformities and the use of computer-navigation in TKA. It covers the principles of deformity correction and soft-tissue balancing in primary TKA in an illustrative, step-wise and algorithmic fashion. Starting with the initial key step of preoperative planning, this book goes on to specifically describe how to deal with different types of deformities encountered in patients who undergo TKA - varus,valgus, flexion,hypertension, rotational and extra-articular deformities - as well as the stiff knee, the unstable knee, osteotomies in primary TKA and postoperative pain management and rehabilitation. This focused how-to manual includesplentiful images and clear, concise text from authors who have performed thousands of TKAs, making it a must-have reference for any surgeon unfamiliar or frequently confronted with this type of procedure.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 184 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson¿s disease, epilepsy, anxiety and depression.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 232 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The recent advent of molecular technologies has changed the way plant breeders identify and select their germplasm as genetic variation can now be assessed at the DNA level. Crop Breeding: Methods and Protocols presents detailed guidelines and tutorials that suit different needs and capacity from small laboratories analyzing molecular markers on a one-by-one basis to the increasingly popular high-throughput protocols for high capacity laboratories. Topics covered include breeding strategy for the selection of an ideal variety or genetic ideo type, protocols for breeders using molecular markers in selection programs and for laboratories providing molecular services to breeding programs, statistical programs and software to aid implementation of molecular data into breeding programs and methodologies that facilitate the generation of genetic diversity and its characterization. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Crop Breeding: Methods and Protocols will help in expanding the use of molecular technologies for the creation of tomorrow¿s crop varieties.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 268 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Axon Growth and Regeneration: Methods and Protocols brings together a diverse set of techniques for the study of the mechanisms underlying central nervous system axon growth, consequently providing a resource that will aid in the development of repair strategies. After an introductory section, this detailed volume continues with sections focusing on axon growth in vitro, providing a range of protocols that can be used to examine intracellular signalling pathways, axonal responses to extracellular factors and methods for quantifying outgrowth. The next section provides protocols for inducing experimental injury in vivo as well as some highly promising protocols for promoting regeneration, which segues into the final section highlighting a series of protocols that can be used to monitor the extent of axon regeneration in vivo, ranging from tract tracing to in vivo imaging and functional recovery. As a book in the Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Practical and reliable, Axon Growth and Regeneration: Methods and Protocols aims to serve researchers studying axon regeneration with a significant set of diverse tools, vital for moving on to the next generation of exciting new discoveries in the field.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 268 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly exploresthis cutting-edge subject.Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 340 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Integrative Weight Management: A Guide for Clinicians intends to educate physicians and nutritionists about the wide ranges of approaches to weight control from non-traditional sources. The options for weight management in conventional practices are limited to a small number of medications, a confusing array of dietary approaches and surgical procedures with their inherent risks and complications. Unfortunately medical practitioners are not exposed to nutrition and weight control principles during training and thus are reluctant to manage their patients weight control issues. This volume is structured into 4 sections: Introduction to Weight Management Disorders; Morbidity and Mortality of Obesity; Therapy of Obesity; and Integrative Medicine and Obesity. Integrative Weight Management: A Guide for Clinicians represents a powerful collaboration of dozens of leading experts in the fields of nutrition, weight management and integrative medicine who have managed countless numbers of patients and summarized the research from thousands of articles to create an up-to- date state of the art guide for healthcare practitioners, allied health professionals and public health authorities who manage those who are overweight/obese along with the associated metabolic consequences. 544 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Inhaltsangabe1. The Role of Carnitine in Cell Metabolism.- A Century of Carnitine Research.- Biosynthesis, Uptake and Excretion.- Carnitine Acyltransferases.- Fatty Acid Oxidation in Liver.- Fatty Acid Oxidation in Heart.- Carnitine in Insulin Secretion.- Perspectives.- 2. Molecular Biology of Carnitine Palmitoyltransferases and Role of Carnitine in Gene Transcription.- Mitochondrial CPTs.- Peroxisomal CPTs.- Microsomal CPTs.- Nuclear CPTs.- A Role for Carnitine in the Transcriptional Regulation.- Perspectives.- 3. Carnitine and Myocardial Glucose Metabolism.- Review of the Literature.- Conclusions.- 4. Carnitine and Mitochondrial Dysfunction.- Mitochondrial Function and Dysfunction.- Carnitine-Related Mitochondrial Disorders.- Carnitine, CoA and Mitochondrial Function.- Carnitine and Mitochondrial Alterations Induced by Anoxia.- 5. Effect of L-Carnitine on Fas-Induced Apoptosis and Sphingomyelinase Activity in Human T Cell Lines.- Materials and Methods.- Effect of Camitine on Fas-Induced Apoptosis in Hut78 and U937 Cells.- Effect of L-Carnitine on Fas Crosslinking-Induced Ceramide Generation in Hut78 and U937 Cells.- Effect of L-Carnitine on Fas Crosslinking-Induced Acidic and Neutral SMases.- Effects of L-Carnitine on Purified Acidic and Neutral SMases in Vitro.- Discussion.- 6. Carnitine Deficiency: Primary and Secondary Syndromes.- Carnitine Metabolism.- Functions of Carnitine.- Carnitine Deficiency in Humans.- Primary Carnitine Deficiencies.- Secondary Carnitine Deficiencies.- Myocardial Diseases and Secondary Carnitine Deficiency.- Diabetes and Secondary Carnitine Deficiency.- Idiopathic Inflammatory Myopathies.- Drugs and Carnitine Deficiency.- 7. Carnitine Against Ischemia and Lipopolysaccharide Toxicity.- L-Carnitine in the Treatment of Ischemic Muscles.- Summary.- 8. Carnitine and Derivatives in Experimental Infections.- Results of Murine Studies.- Results of Rat Studies.- Discussion.- 9. Involvement of Carnitine in Reye's and Reye-Like Syndromes.- Definition of Reye's and Reye-Like Syndromes.- Pathological Manifestation of RS and RLS.- Involvement of Carnitine.- Carnitine Treatment in RS and RLS.- 10. Fatigue Syndrome.- Summary.- Acylcarnitine (ACR) Deficiency in CFS.- ACR Metabolism in Mammals.- The Uptake of ACR in the Brain of Rhesus Monkeys and Humans.- Hypothesis: the Role of ACR in the Etiology of CFS.- Acetyl-L-Camitine Treatment for Patients with CFS.- 11. L-Carnitine, a Modulator of Immunometabolic Homeostasis in Subjects Infected with the Human Immunodeficiency Virus.- Immunomodulating Properties of L-Carnitine.- Serum and Cellular Carnitine Deficiency in HIV-Infected Subjects.- Carnitine Deficiency and Mitochondrial Toxicity of Nucleoside Analogs.- Etiology of Carnitine Deficiency in AIDS.- Impact of L-Carnitine Therapy on Lymphocyte Mitogen Responsiveness and Carnitine Cellular Content.- Impact of L-Carnitine Therapy on Lymphocyte Apoptosis, CD4 Cell Decline and HIV Viremia.- Concluding Remarks.- 12. Effect of L-Carnitine on the AZT-Induced Mitochondrial Toxicity: Studies on Human Muscle Cultures.- In Vitro Studies.- In Vivo Studies.- Conclusions.- 13. Possible Anti-Apoptotic Activity of Carnitines on Excitatory Amino Acid-Induced Neurotoxicity.- Glutamate and Cancer.- Glutamate May Mediate Some Neurological Disorders.- Pharmacotherapy for Excitatory Amino Acid-Induced Neurotoxicity.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 288 pp. Englisch.…