Humana okt 2014 (148 risultati)

Taschenbuch. Condizione: Neu. Neuware -Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines.Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer. 216 pp. Englisch.…

Taschenbuch. Condizione: Neu. Neuware -Allergic diseases affect nearly one-fourth of the population and cause or contribute to significant chronic illness. Allergic diseases are common and are seen by a wide variety of health care providers. In Clinical Allergy: Diagnosis and Management, the author provides a practical clinical overview for the common disorders encountered in the specialty of Allergy. Designed to be easily readable and to provide clinically applicable information for both the nonallergist and allergist, the intent is to unravel the mystery of allergy. The introductory chapters focus on the human immune response, environmental allergens, and the different types of allergy testing. The subsequent chapters focus on the common allergic conditions seen in the office or clinic, including rhinitis and rhinosinusitis, allergic eye disease, asthma, urticaria and angioedema, atopic and contact dermatitis, drug allergy, food allergy, anaphylaxis, and stinging insect allergy. 'Cross-talk' between chapters helps show the interrelationships among the various allergic disorders. The chapters begin with a review of pathophysiologic mechanisms and then consider a clinically structured approach to diagnosis and management of the disorders. In addition to pharmacologic treatment, the importance of nonpharmacologic management and patient education is emphasized. At the end of each chapter, clinical vignettes highlight the daily management of the allergic patient. Clinical Allergy: Diagnosis and Management, provides a logical framework for the evaluation and management of allergic disorders in patients. 512 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents numerical and other approximation techniques for solving various types of mathematical problems that cannot be solved analytically. In addition to well known methods, it contains some non-standard approximation techniques that are now formally collected as well as original methods developed by the author that do not appear in the literature.This book contains an extensive treatment of approximate solutions to various types of integral equations, a topic that is not often discussed in detail. There are detailed analyses of ordinary and partial differential equations and descriptions of methods for estimating the values of integrals that are presented in a level of detail that will suggest techniques that will be useful for developing methods for approximating solutions to problems outside of this text.The book is intended for researchers who must approximate solutions to problems that cannot be solved analytically. It is also appropriatefor students taking courses in numerical approximation techniques. 500 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this book is to provide the reader with a solid background and understanding of the basic results and methods in probability theory before entering into more advanced courses (in probability and/or statistics). The presentation is fairly thorough and detailed with many solved examples. Several examples are solved with di erent methods in order to illustrate their di erent levels of sophistication, their pros, and their cons. The motivation for this style of exposition is that experience has proved that the hard part in courses of this kind usually is the application of the results and methods; to know how, when, and where to apply what; and then, technically, to solve a given problem once one knows how to proceed. Exercises are spread out along the way, and every chapter ends with a large selection of problems. Chapters 1 through 6 focus on some central areas of what might be called pure probability theory: multivariate random variables, conditioning, tra- forms, order variables, the multivariate normal distribution, and convergence. 320 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rooted in a pedagogically successful problem-solving approach to linear algebra, this work fills a gap in the literature that is sharply divided between, on the one end, elementary texts with only limited exercises and examples, and, at the other end, books too advanced in prerequisites and too specialized in focus to appeal to a wide audience. Instead, it clearly develops the theoretical foundations of vector spaces, linear equations, matrix algebra, eigenvectors, and orthogonality, while simultaneously emphasizing applications to fields such as biology, economics, computer graphics, electrical engineering, cryptography, and political science.Key features:\* Intertwined discussion of linear algebra and geometry\* Example-driven exposition; each section starts with a concise overview of important concepts, followed by a selection of fully-solved problems\* Over 500 problems are carefully selected for instructive appeal, elegance, and theoretical importance; roughly half include complete solutions\* Two or more solutions provided to many of the problems; paired solutions range from step-by-step, elementary methods whose purpose is to strengthen basic comprehension to more sophisticated, powerful proofs to challenge advanced readers\* Appendices with review material on complex variablesIdeal as an introduction to linear algebra, the extensive exercises and well-chosen applications also make this text suitable for advanced courses at the junior or senior undergraduate level. It can serve as a colorful supplementary problem book, reference, or self-study manual for professional scientists and mathematicians. Complete with bibliography and index, this work is a natural bridge between pure/ applied mathematics and the natural/social sciences, appropriate for any student or researcher who needs a strong footing in the theory, problem-solving, and model-building that are the subject's hallmark. 504 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book, from the faculty and residents of one of the world¿s most respected hospitals, provides a comprehensive and concise approach to vascular disease. Beginning with the foundations of vascular disease and diagnosis, this text moves on to cover critical disease processes. Each section of the book, dedicated to a unique pathology, explains salient pathophysiology, presentation, diagnosis, treatment options, and outcomes. A special emphasis is given to both open and endovascular techniques and their related pitfalls. Additionally, reflecting the growing importance of evidence-based medicine, readers are provided with references to critical publications that underpin diagnostic and therapeutic recommendations.Diagnosis, treatment, and more are provided succinctly, allowing this text to be broad in focus while remaining in a convenient portable format. As a brief review for practicing physicians or a primary educational text for fellows, residents, and medical students, Cleveland Clinic Manual of Vascular Surgery is a valuable addition to everyone¿s library.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 164 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The book is intended for students who want to learn how to prove theorems and be better prepared for the rigors required in more advance mathematics. One of the key components in this textbook is the development of a methodology to lay bare the structure underpinning the construction of a proof, much as diagramming a sentence lays bare its grammatical structure. Diagramming a proof is a way of presenting the relationships between the various parts of a proof. A proof diagram provides a tool for showing students how to write correct mathematical proofs.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 372 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Receptor Tyrosine Kinases: Methods and Protocols explores on the most widely studied of the protein classes, known for their central role in several cellular functions and in a variety of human pathologies. Beginning with a section on activation and signaling of Receptor Tyrosine Kinases (RTKs), the book continues with chapters on aberrant expression of RTKs, trafficking and negative regulation, as well as RTKs as pharmacological targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Receptor Tyrosine Kinases: Methods and Protocols contains an up-to-date overview of the most relevant and widely used methods employed in this field, providing detailed protocols that molecular and cellular biologists could easily adopt in their research programs on RTKs.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 196 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume emphasizes new techniques to help understand protein cages and to apply them to a variety of technologies, highlighting the expertise of researchers based on three continents. Protein cages are currently inspiring diverse scientific disciplines and are therefore at the crossroads of extremely widely-scoped research, which is reflected in the detailed chapters of Protein Cages: Methods and Protocols. From nanomaterials studies and iron particles to computational strategies and Atomic Force Microscopy, the chapters herein collectively provide an introduction to the rich world of protein cage research and specific techniques to understand and exploit this fascinating class of proteins. Written in the highly successful Methods in Molecular Biology series format, chapters begin with an introduction to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and cutting-edge, Protein Cages: Methods and Protocols will help to inspire and further propel the current multi-disciplinary enthusiasm in studying and discovering new applications for protein cages.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 200 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Distributed Programming: Theory and Practice presents a practical and rigorous method to develop distributed programs that correctly implement their specifications. The method also covers how to write specifications and how to use them. Numerous examples such as bounded buffers, distributed locks, message-passing services, and distributed termination detection illustrate the method. Larger examples include data transfer protocols, distributed shared memory, and TCP network sockets.Distributed Programming: Theory and Practice bridges the gap between books that focus on specific concurrent programming languages and books that focus on distributed algorithms. Programs are written in a 'real-life' programming notation, along the lines of Java and Python with explicit instantiation of threads and programs.Students and programmers will see these as programs and not 'merely' algorithms in pseudo-code. The programs implement interesting algorithms and solve problems that are large enough to serve as projects in programming classes and software engineering classes. Exercises and examples are included at the end of each chapter with on-line access to the solutions.Distributed Programming: Theory and Practice is designed as an advanced-level text book for students in computer science and electrical engineering. Programmers, software engineers and researchers working in this field will also find this book useful.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 404 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume presents detailed, recently-developed protocols ranging from isolation of nuclei to purification of chromatin regions containing single genes, with a particular focus on some less well-explored aspects of the nucleus. The methods described include new strategies for isolation of nuclei, for purification of cell type-specific nuclei from a mixture, and for rapid isolation and fractionation of nucleoli. For gene delivery into and expression in nuclei, a novel gentle approach using gold nanowires is presented. As the concentration and localization of water and ions are crucial for macromolecular interactions in the nucleus, a new approach to measure these parameters by correlative optical and cryo-electron microscopy is described. The Nucleus, Second Edition presents methods and software for high-throughput quantitative analysis of 3D fluorescence microscopy images, for quantification of the formation of amyloid fibrils in the nucleus, and for quantitative analysis of chromosome territory localization. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, The Nucleus, Second Edition seeks to serve both professionals and novices with its well-honed methods for the study of the nucleus.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 252 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The top quark is by far the heaviest known fundamental particle with a mass nearing that of a gold atom. Because of this strikingly high mass, the top quark has several unique properties and might play an important role in electroweak symmetry breaking¿the mechanism that gives all elementary particles mass. Creating top quarks requires access to very high energy collisions, and at present only the Tevatron collider at Fermilab is capable of reaching these energies.Until now, top quarks have only been observed produced in pairs via the strong interaction. At hadron colliders, it should also be possible to produce single top quarks via the electroweak interaction. Studies of single top quark production provide opportunities to measure the top quark spin, how top quarks mix with other quarks, and to look for new physics beyond the standard model. Because of these interesting properties, scientists have been looking for single top quarks for more than 15 years.This thesis presents the first discovery of single top quark production. It documents one of the flagship measurements of the D0 experiment, a collaboration of more than 600 physicists from around the world. It describes first observation of a physical process known as ¿single top quark production¿, which had been sought for more than 10 years before its eventual discovery in 2009. Further, his thesis describes, in detail, the innovative approach Dr. Gillberg took to this analysis. Through the use of Boosted Decision Trees, a machine-learning technique, he observed the tiny single top signal within an otherwise overwhelming background.This Doctoral Thesis has been accepted by Simon Fraser University, Burnaby, BC, Canada.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 156 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Cultural heritage is material ¿ tangible and intangible ¿ that signifies a culture¿s history or legacy. It has become a venue for contestation, ranging in scale from protesting to violently claimed and destroyed. But who defines what is to be preserved and what is to be erased As cultural heritage becomes increasingly significant across the world, the number of issues for critical analysis and, hopefully, mediation, arise.The issue stems from various groups: religious, ethnic, national, political, and others come together to claim, appropriate, use, exclude, or erase markers and manifestations of their own and others¿ cultural heritage as a means for asserting, defending, or denying critical claims to power, land, and legitimacy.Can cultural heritage be well managed and promoted while at the same time kept within parameters so as to diminish contestation The cases herein rage from Greece, Spain, Egypt, the UK, Syria, Zimbabwe, Italy, the Balkans, Bénin, and Central America.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 296 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway. Chapters focus on assays developed to detect its activation not only in vitro but also in vivo, optimized multiplex analysis, medium- to high-throughput screens, and the cellular process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Apoptosis and Cancer: Methods and Protocols, Second Edition aids scientists as a stand-alone resource for the execution and analysis of the described protocols and as a reference for the study and detection of apoptosis within and outside the area of cancer research.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 220 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As the obesity epidemic widens to all age groups and nations, chronic conditions increase in frequency, and populations grow in number, the costs of treatment will exhaust future health care resources. The only alternative is population-based m- agement emphasizing prevention, health promotion, and environmental modifi- tions. Dissemination of information on risk factors derived from epidemiologic studies to evoke individual, community, and policy change is a strategy in suppo- ing this approach. Complementing this needs to be health care services based upon the knowledge and application of epidemiologic concepts and methods to achieve control of existing and emerging health problems given resource constraints and ethical considerations. While some of these health problems and their consequences are predictable and generally addressed by health systems, health care services need to address unpredictable exposures and events as well. Epidemiology also provides a framework for planning health services for unpredictable events such as natural and man-made disasters. This text focuses on the unique application of epidemiology to health care m- agement practice, regardless of the setting of that practice. This emerging discipline termed is 'managerial epidemiology. ' Managerial epidemiology draws from the traditional disciplines of public health, epidemiology, and health care management for improving the health of populations, be those in communities or served by health plans or systems. 364 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Perioperative Addiction addresses an issue that every anesthesiologist will encounter many times during the course of his or her career: the patient who arrives for operative care under the influence of legal or illegal drugs. The editors and contributors provide expert guidance on how to identify and manage the addicted patient, approaching the subject from the vantage points of the specific drug and of special patient populations. Features: Guidance for spotting and managing addicted patients All common and important drugs of addiction, from opioids, cocaine, club drugs, and alcohol, to tobacco, marijuana, nitrous oxide, inhalants, and propofol Special populations, including pregnant women, pain patients, adolescents, older patients, and healthcare professionals Fascinating overview of the long history of addiction Genetic basis of addiction, and the range of pharmacological treatments for addiction 304 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book targets custom IC designers who are encountering variation issues in their designs, especially for modern process nodes at 45nm and below, such as statistical process variations, environmental variations, and layout effects. It teaches them the state-of-the-art in Variation-Aware Design tools, which help the designer to analyze quickly the variation effects, identify the problems, and fix the problems. Furthermore, this book describes the algorithms and algorithm behavior/performance/limitations, which is of use to designers considering these tools, designers using these tools, CAD researchers, and CAD managers. 204 pp. Englisch. …

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Solving multi-objective problems is an evolving effort, and computer science and other related disciplines have given rise to many powerful deterministic and stochastic techniques for addressing these large-dimensional optimization problems. Evolutionary algorithms are one such generic stochastic approach that has proven to be successful and widely applicable in solving both single-objective and multi-objective problems. This textbook is a second edition of Evolutionary Algorithms for Solving Multi-Objective Problems, significantly expanded and adapted for the classroom. The various features of multi-objective evolutionary algorithms are presented here in an innovative and student-friendly fashion, incorporating state-of-the-art research. The book disseminates the application of evolutionary algorithm techniques to a variety of practical problems, including test suites with associated performance based on a variety of appropriate metrics, as well as serial and parallel algorithm implementations. 824 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book developed out of my year-long course on asymptotic theory at Purdue University. To some extent, the topics coincide with what I cover in that course. There are already a number of well-known books on asy- totics. This book is quite different. It covers more topics in one source than areavailableinanyothersinglebookonasymptotictheory. Numeroustopics covered in this book are available in the literature in a scattered manner, and they are brought together under one umbrella in this book. Asymptotic theory is a central unifying theme in probability and statistics. My main goal in writing this book is to give its readers a feel for the incredible scope and reach of asymptotics. I have tried to write this book in a way that is accessible and to make the reader appreciate the beauty of theory and the insights that only theory can provide. Essentially every theorem in the book comes with at least one reference, preceding or following the statement of the theorem. In addition, I have p- vided a separate theorem-by-theorem reference as an entry on its own in the front of the book to make it extremely convenient for the reader to nd a proof that was not provided in the text. Also particularly worth mentioning is a collection of nearly 300 practically useful inequalities that I have c- lected together from numerous sources. This is appended at the very end of the book. 756 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Spatial trajectories have been bringing the unprecedented wealth to a variety of research communities. A spatial trajectory records the paths of a variety of moving objects, such as people who log their travel routes with GPS trajectories. The field of moving objects related research has become extremely active within the last few years, especially with all major database and data mining conferences and journals.Computing with Spatial Trajectories introduces the algorithms, technologies, and systems used to process, manage and understand existing spatial trajectories for different applications. This book also presents an overview on both fundamentals and the state-of-the-art research inspired by spatial trajectory data, as well as a special focus on trajectory pattern mining, spatio-temporal data mining and location-based social networks. Each chapter provides readers with a tutorial-style introduction to one important aspect of location trajectory computing, case studies and many valuable references to other relevant research work.Computing with Spatial Trajectories is designed as a reference or secondary text book for advanced-level students and researchers mainly focused on computer science and geography. Professionals working on spatial trajectory computing will also find this book very useful.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 336 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book presents numerical and other approximation techniques for solving various types of mathematical problems that cannot be solved analytically. In addition to well known methods, it contains some non-standard approximation techniques that are now formally collected as well as original methods developed by the author that do not appear in the literature.This book contains an extensive treatment of approximate solutions to various types of integral equations, a topic that is not often discussed in detail. There are detailed analyses of ordinary and partial differential equations and descriptions of methods for estimating the values of integrals that are presented in a level of detail that will suggest techniques that will be useful for developing methods for approximating solutions to problems outside of this text.The book is intended for researchers who must approximate solutions to problems that cannot be solved analytically. It is also appropriatefor students taking courses in numerical approximation techniques.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 500 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As experimentation and clinical trials with first generation anti-angiogenic agents have yielded results and our understanding of the biology and physiology of blood and lymphatic vessels has increased, a new angiogenesis volume swiftly became a necessity. Angiogenesis Protocols, Second Edition remains true to its original vision of providing a single source for angiogenesis researchers, irrespective of levels of resource and expertise, by collecting a range of methods for cell isolation and assessing angiogenesis in vivo or in vitro. This information, however, is expanded to include chapters on circulating endothelial progenitor cells, angiogenic signalling pathways, imaging of angiogenesis, and measurement of tissue blood flow. Written in the Methods in Molecular Biology(TM) series format, the chapters provide step-by-step laboratory protocols, lists of necessary materials and reagents, and a Notes section, which details tips on troubleshooting and avoiding known pitfalls.Extensive and cutting-edge, Angiogenesis Protocols, Second Edition is not only a practical handbook for key techniques, but also an informative and enjoyable read for all those interested, no matter how directly, in angiogenesis. 380 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-depth insights into presentations of genomic signal processing. Also detailed is the use of tiling arrays for large genomes analysis.The protocols follow the successful Methods in Molecular Biology(TM) series format, offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls. 288 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular Biology(TM) series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls.Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology. 460 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology(TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases. 220 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In Proteases and Cancer: Methods and Protocols, expert researchers bring together a wide range of current, complimentary techniques that have been developed for the specific detection and analysis of proteases and their activities in cancer biology. The volume covers vital topics including the application of proteomics technologies for the detection of protease expression in tumors, imaging proteases by activity profiling, proteomics technologies for the identification of biological substrates, detection of cell surface proteolysis, imaging of protease activity, the use of transgenic mice to determine protease function in tumor initiation and progression, and the development of anti-protease therapies for cancer. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easy to use, Proteases and Cancer: Methods and Protocols is an ideal guide for scientists who wish to pursue the study of this important branch of cancer research and the development of unique innovative technologies to aid in that study. 236 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 400 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data. 304 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Simple carbohydrates, complex oligosaccharides and polysaccharides all belong to a class of ubiquitous (macro)molecules that exhibit a wide range of biological functions, and the recent advent of enhanced enzymatic, chemical and analytical tools used to study these sugars has inaugurated a genuine explosion in the field of glycomics. Specifically, it has led to a deeper understanding of how specific sugar structures modulate cellular phenotypes, and that breakthrough has led to the discovery of new pharmaceuticals for the treatment of many serious diseases, such as cancer. The subsequent rapid expansion of this research holds high promise for future therapeutic regimens, and capillary electrophoresis (CE) refers to the range of related separation techniques that are integral to this vital research.CE uses narrow-bore fused-silica capillaries to separate a complex array of large and small molecules, and Capillary Electrophoresis of Carbohydrates offers a comprehensive look at the latest breakthroughs and improvements in CE and CE techniques applied to monosaccharides up to complex oligosaccharides and polysaccharides. It begins with an overview of the application of CE and CE- mass spectrometric in the analysis of simple carbohydrates without any previous derivatization step before discussing various detection techniques such as spectrophotometric detection, electrochemical detection and other less common techniques. It then covers in detail an array of related topics and numerous applications. It is an essential text for anyone exploring the myriad possibilities of this rapidly expanding field. 292 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. 200 pp. Englisch.…