springer netherlands springer netherlands okt 2015 (44 risultati)

Taschenbuch. Condizione: Neu. Neuware -In this book, the authors discuss the biophysical characteristics of Dendritic cells (DCs) at various differentiation stages and in tumor microenvironments in detail. A type of Chinese traditional herb, which can improve the biophysical and microrheological properties of DCs, is also introduced. DCs are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The biophysical and microrheological characteristics of DCs are important for their motility and normal immune function. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown. This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency ofanti-tumor therapy based on DCs. 76 pp. Englisch.

Buch. Condizione: Neu. Neuware -The volume offers an exploration of methods for analysis of emotion in negotiation, such as cognitive modeling, discourse analysis, all testing, subsequent multidimensional scaling, impression rating, and graph modeling for conflict resolution, reasonable and unreasonable disagreement.It covers activities, such as business negotiation, conflict solving, bargaining, task management meetings, discussions, and elaborates on different kinds of emotions. Some emotions stimulate negotiation (e.g. empathy), others -hinder it (e.g. disgust). However, all emotions open a door to uncertainty in relations and negotiation, which in turn provides an opportunity.The volume views language in negotiation not only as a vehicle for transmission of thought but also as a manifestation of emotion and the ethical.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencinganalyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, as well as protein and gene expression data integration in complex human diseases etc. The book is particularly useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, as well as physicians etc.Dr. Jiaqian Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Centre, Houston, TX, USA.¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 196 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book contains the full set of RILEM Recommendations which have been produced to enable engineers, specifiers and testing houses to design and produce concrete which will not suffer damage arising from alkali reactions in the concrete. There are five recommended test methods for aggregates (designated AAR-1 to AAR-5), and an overall recommendation which describes how these should be used to enable a comprehensive aggregate assessment (AAR-0). Additionally, there are two Recommended International Specifications for concrete (AAR-7.1 & 7.2) and a Preliminary International Specification for dams and other hydro structures (AAR-7.3), which describe how the aggregate assessment can be combined with other measures in the design of the concrete to produce a concrete with a minimised risk of developing damage from alkali-aggregate reactions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Buch. Condizione: Neu. Neuware -In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book presents research into chemical, biological, radiological and nuclear (CBRN) defense and environmental security, exploring practical implications of the research. Contributions from a diverse group of international civilian researchers present the latest work on nanotechnology problems in this area, looking at detection, protective technologies, decontamination and threats to environmental security due to bacteriophages and nanomaterials.Highlights include the potential of Atomic Force Microscopy (AFM) to characterize the nanoscale properties of microbial pathogens, the development of bacteriophage-based therapeutics, prophylactic and diagnostic preparations and their uses in different fields, such as medicine, veterinary, agriculture, food and water safety, amongst others.Readers may also consider an inexpensive bioassay suited for assessing chemical poisoning in the environment such as the presence of pesticides, sensors to detect ultra-trace quantities of the explosive Pentaerythritol tetranitrate (PETN) using nanotubes and electrochemical sensors to simultaneously detect and reduce the explosive trinitrotoluene (TNT) to 2,4,6-triaminotoluene (TAT) in solution.This book shows how cooperative research among NATO countries and NATO partners can make a critical contribution to meeting the opportunities and challenges of nanotechnology problems relevant to chemical and biological defense needs.The papers presented here are representative of contributions made to the Advanced Research Workshop (ARW) on September 22-26, 2014 in Antalya, Turkey, to address the NATO SPS Key Priority of Defense against CBRN Agents and Environmental Security.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Buch. Condizione: Neu. Neuware -The book mainly introduces readers to the development and current status of water quality criteria (WQC) in China and other countries or areas, and proposes a minimum toxicity data requirement (MTDR; i.e., six species from three phyla) as the principle metric for deriving WQC in China. Further, ten model species from 4 different phyla are recommended as domestic test species, and the methodologies for deriving aquatic life criteria, sediment criteria, ecocriteria and nutrient criteria in China are also described in detail. In order to demonstrate the methods, several representative chemical pollutants and aquatic environments are highlighted as examples. The book provides important references for future WQC-related research in China, which will make it of great interest to researchers and graduate students in the fields of environmental science, ecology and aquatic science etc.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 180 pp. Englisch.

Buch. Condizione: Neu. Neuware -This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors.Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery.This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book presents research into chemical, biological, radiological and nuclear (CBRN) defense and environmental security, exploring practical implications of the research. Contributions from a diverse group of international civilian researchers present the latest work on nanotechnology problems in this area, looking at detection, protective technologies, decontamination and threats to environmental security due to bacteriophages and nanomaterials.Highlights include the potential of Atomic Force Microscopy (AFM) to characterize the nanoscale properties of microbial pathogens, the development of bacteriophage-based therapeutics, prophylactic and diagnostic preparations and their uses in different fields, such as medicine, veterinary, agriculture, food and water safety, amongst others.Readers may also consider an inexpensive bioassay suited for assessing chemical poisoning in the environment such as the presence of pesticides, sensors to detect ultra-trace quantities of the explosive Pentaerythritol tetranitrate (PETN) using nanotubes and electrochemical sensors to simultaneously detect and reduce the explosive trinitrotoluene (TNT) to 2,4,6-triaminotoluene (TAT) in solution.This book shows how cooperative research among NATO countries and NATO partners can make a critical contribution to meeting the opportunities and challenges of nanotechnology problems relevant to chemical and biological defense needs.The papers presented here are representative of contributions made to the Advanced Research Workshop (ARW) on September 22-26, 2014 in Antalya, Turkey, to address the NATO SPS Key Priority of Defense against CBRN Agents and Environmental Security.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a practical strategy for obtaining a more complete and accurate geologic site characterization. The strategy and methods to characterize complex geologic settings are readily available. The strategy utilizes readily available technology, basic science and good, old-fashioned common sense resulting in a solid understanding of geologic and even karst or pseudokarst conditions. We provide an introduction to many off-the-shelf methods available for site characterization as well as examples of their application throughout the book.The purpose of a geologic site characterization is to understand the 3-dimensional geologic framework, along with the engineering and hydrologic properties of a site including any man-made impacts. A well-done site characterization is the cornerstone of all geotechnical, groundwater and environmental projects. The geologic conditions, particularly karst conditions, can significantly impact a site including its structural stability, groundwater pathways and potential for rapid transport or traps for contaminants. Once we have adequately characterized the geologic conditions can we carry our remediation, design and construction, model flow, and make risk assessments that are accurate and reliable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book summarizes major aspects of the evolution of South American metatherians, including their epistemologic, phylogenetic, biogeographic, faunal, tectonic, paleoclimatic, and metabolic contexts. A brief overview of the evolution of each major South American lineage ('Ameridelphia', Sparassodonta, Didelphimorphia, Paucituberculata, Microbiotheria, and Polydolopimorphia) is provided.It is argued that due to physiological constraints, metatherian evolution closely followed the conditions imposed by global temperatures. In general terms, during the Paleocene and the early Eocene multiple radiations of metatherian lineages occurred, with many adaptive types exploiting insectivorous, frugivorous, and omnivorous adaptive zones. In turn, a mixture of generalized and specialized types, the latter mainly exploiting carnivorous and granivorous-folivorous adaptive zones, characterized the second half of the Cenozoic. In both periods, climate was the critical driver of their radiation andturnovers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Condizione: Neu. Neuware -This work gives an overview of significant research from recent years concerning performance-based design and quality control for concrete durability and its implementation. In engineering practice, performance approaches are often still used in combination with prescriptive requirements. This is largely because, for most durability test methods, sufficient practical experience still has to be gained before engineers and owners are prepared to fully rely on them.This book, compiled by RILEM TC 230-PSC, is intended to assist efforts to successfully build the foundation for the full implementation of performance-based approaches through the exchange of relevant knowledge and experience between researchers and practitioners worldwide.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Buch. Condizione: Neu. Neuware -Digital games offer enormous potential for learning and engagement in mathematics ideas and processes. This volume offers multidisciplinary perspectives¿of educators, cognitive scientists, psychologists and sociologists¿on how digital games influence the social activities and mathematical ideas of learners/gamers. Contributing authors identify opportunities for broadening current understandings of how mathematical ideas are fostered (and embedded) within digital game environments. In particular, the volume advocates for new and different ways of thinking about mathematics in our digital age¿proposing that these mathematical ideas and numeracy practices are distinct from new literacies or multiliteracies. The authors acknowledge that the promise of digital games has not always been realised/fulfilled. There is emerging, and considerable, evidence to suggest that traditional discipline boundaries restrict opportunities for mathematical learning.Throughout the book, what constitutes mathematics learnings and pedagogy is contested. Multidisciplinary viewpoints are used to describe and understand the potential of digital games for learning mathematics and identify current tensions within the field.Mathematics learning is defined as being about problem solving; engagement in mathematicalideas and processes; and social engagement. The artefact, which is the game, shapes the ways in which the gamers engage with the social activity of gaming. In parallel, the book (as a textual artefact) will be supported by Springer¿s online platform¿allowing for video and digital communication (including links to relevant websites) to be used as supplementary material and establish a dynamic communication space.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Buch. Condizione: Neu. Neuware -Most neonates who now survive intensive care would have died 50 years ago, and ¿nature¿ would have decided the outcomes, making ethical discussions about initiating or withholding resuscitation irrelevant. Medical developments in neonatology have changed the way we respond to diseases of neonates, to their illness, and to their parents. Not only as physicians, but also as a society.Decisions on when to start, withhold, or withdraw life-saving interventions in critically ill neonates are among the most difficult decisions in pediatric practice. These decisions are fraught with ethical dilemmas, for example deciding whether withholding intensive care ¿leading to death- is superior to uncertain survival with a risk of disability and the additional burden of intensive care. This book covers important ethical questionsthat arise inneonatal intensive care units.Questions such as, whether to intervene medically and whether we are good at predicting the outcome of fragile neonates; whether a medical intervention should be withheld or withdrawn, and who should be primarily responsible for these decisions and how Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 104 pp. Englisch.

Buch. Condizione: Neu. Neuware -N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced.Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials.Written and edited by some of the world¿s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Buch. Condizione: Neu. Neuware -This double-volume work focuses on socio-demographics and the use of such data to support strategic resource management and planning initiatives. Papers go beyond explanations of methods, technique and traditional applications to explore new intersections in the dynamic relationship between the utilization and management of resources, and urban development.International authors explore numerous experiences, characteristics of development and decision-making influences from across Asia and Southeast Asia, as well as recounting examples from America and Africa. Papers propound techniques and methods used in geographical research such as support vector machines, socio-economic correlates and travel behaviour analysis.In this volume the contributions examine issues such as natural resource and environmental management, livelihoods issues in the context of climate change, land markets and land trusts, adaptive management of wildlife sanctuaries, ground water scarcity, flood hazards and flood plain management, non-conventional energy resources, community forestry and management and land use and land cover change. The significance of these topics lie in the pace and volume of change as is reflected through continued development within established fields of inquiry and the introduction of significantly new approaches during the last decade.Readers are invited to consider the dynamics of spatial expansion of urban areas and economic development, and to explore conceptual discussion of the innovations in and challenges on urbanization processes, urban spaces themselves and both resource management and environmental management.Together, the two volumes contribute to the interdisciplinary literature on regional resources and urban development by collating recent research with geography at its core. Scholars of urban geography, human geography, urbanism and sustainable development will be particularly interested in this book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 580 pp. Englisch.

Buch. Condizione: Neu. Neuware -This extensive work focuses on an important group of temperate freshwater fish, approaching the topic from the perspectives of both biology and aquaculture. It compiles the latest research on fish belonging to the Percidae family and describes in detail all biological aspects relevant to the culture of different species, including ecology, reproductive physiology, feeding and nutrition, genetics, immunology, stress physiology and behavior. It also considers commercial fish production and fish farming topics, such as protocols for induction of gonad maturation, spawning, incubation and larval rearing.Expert contributors not only provide a critical peer review of scientific literature but also original research data, and identify effective practical techniques. The book features chapters on systematics, ecology and evolution, on development, metabolism and husbandry of early life stages and on growth, metabolism, behavior and husbandry of juvenile and grow-out stages. Furthermore, the authors consider genetic improvement and domestication, as well as diseases and health management, crucial to the readers' understanding of these fish and how they can be cultured.Both researchers of percid fish biology and aquaculture professionals who are considering intensive and pond culture of percid fishes will value this timely and comprehensive handbook.)Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 920 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book presents original happiness research from and about a region that showsunexpectedly high levels of happiness.Even when Latin American countries cannot be classified as high-income countries their population do enjoy, on average, high happiness levels. The book draws attention to some important factors that contribute to the happiness of people, such as: relational values, human relations, solidarity networks, the role of the family, and the availability and gratifying using of leisure time. In a world where happiness is acquiring greater relevance as a final social and personal aim both the academic community and the social-actors and policy-makers community would benefit from Happiness Research in Latin America.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 652 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume collects the state-of-the-art research on forgiveness and mental and physical health and well-being. It focuses specifically on connections between forgiveness and its health and well-being benefits. Forgiveness has been examined from a variety of perspectives, including the moral, ethical and philosophical. Ways in which to become more forgiving and evolutionary theories of revenge and forgiveness have also been investigated and proposed. However, little attention has been paid to the benefits of forgiveness.This volume offers an examination of the theory, methods and research utilized in understanding these connections. It considers trait and state forgiveness, emotional and decisional forgiveness, and interventions to promote forgiveness, all with an eye toward the positive effects of forgiveness for a victim¿s health and well-being. Finally, this volume considers key moderators such as gender, race, and age, as well as, explanatory mechanisms that might mediate links between forgiveness and key outcomes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Buch. Condizione: Neu. Neuware -Medicinal and aromatic plants (MAPs) have accompanied mankind from its very early beginnings. Their utilization has co-evolved with homo sapiens itself bringing about a profound increase in our scientific knowledge of these species enabling them to be used in many facets of our life (e.g. pharmaceutical products, feed- and food additives, cosmetics, etc.). Remarkably, despite the new renaissance of MAPs usage, ca. 80 % of the world¿s population is relying on natural substances of plant origin, with most of these botanicals sourced from the wild state. This first volume and ultimately the series, provides readers with a wealth of information on medicinal and aromatic plants.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 468 pp. Englisch.

Buch. Condizione: Neu. Neuware -True bugs (Heteroptera) are a diverse and complex group of plant-feeding and predatory insects important to food production, human health, the global economy and the environment. Within the nearly 43,000 species described around the world, Neotropical true bugs are particularly diverse, and much remains to be discovered about their biology and relations with other species. Inspired by the need for a comprehensive assessment,True Bugs (Heteroptera) of the Neotropicsis the most complete and thorough review ever published.Experts in each of the seven infraorders have drawn together the scattered literature to provide detailed treatments of each major taxon. The most common and important species as well as select lesser known species in each major family are covered, highlighting morphology, classification, biology and ecology. The numerous color illustrations highlight key species and their adaptations, and importance to basic and applied sciences is discussed.Each chapter is based on an up-to-date review of the literature, and with a bibliography of more than 3,000 references, readers are presented with an unprecedented and vital and timely account of the true bugs of the Neotropical Region.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 924 pp. Englisch.

Buch. Condizione: Neu. Neuware -This is the first comprehensive volume to explore and engage with current trends in Geographies of Media research. It reviews how conceptualizations of mediated geographies have evolved. Followed by an examination of diverse media contexts and locales, the book illustrates key issues through the integration of theoretical and empirical case studies, and reflects on the future challenges and opportunities faced by scholars in this field. The contributions by an international team of experts in the field, address theoretical perspectives on mediated geographies, methodological challenges and opportunities posed by geographies of media, the role and significance of different media forms and organizations in relation to socio-spatial relations, the dynamism of media in local-global relations, and in-depth case studies of mediated locales. Given the theoretical and methodological diversity of this book, it will provide an important reference for geographers and other interdisciplinary scholars working in cultural and media studies, researchers in environmental studies, sociology, visual anthropology, new technologies, and political science, who seek to understand and explore the interconnections of media, space and place through the examples of specific practices and settings.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 480 pp. Englisch.