springer us feb 2007 (16 risultati)

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Government interference in free enterprise is growing. Should they intercede in business ethics and corporate responsibility; and if so, to what extent The Morality of Business: A Profession for Human Wealthcare goes beyond the utilitarian case in discussing the various elements of business ethics, social policy, job security, outsourcing, government regulation, stakeholder theory, advertising and property rights. 152 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Computational Intelligence is tolerant of imprecise information, partial truth and uncertainty. This book presents a selected collection of contributions on a focused treatment of important elements of CI, centred on its key element: learning. This book presents novel applications and real world applications working in Manufacturing and Engineering, and it sets a basis for understanding Domotic and Production Methods of the XXI Century. 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Modern science and technology, from materials science to integrated circuit development, is directed toward the nanoscale. From thin films to field effect transistors, the emphasis is on reducing dimensions from the micro to the nanoscale. Fundamentals of Nanoscale Film Analysis concentrates on analysis of the structure and composition of the surface and the outer few tens to hundred nanometers in depth. It describes characterization techniques to quantify the structure, composition and depth distribution of materials with the use of energetic particles and photons.The book describes the fundamentals of materials characterization from the standpoint of the incident photons or particles which interrogate nanoscale structures. These induced reactions lead to the emission of a variety of detected of particles and photons. It is the energy and intensity of the detected beams that is the basis of the characterization of the materials. The array of experimental techniques used in nanoscale materials analysis covers a wide range of incident particle and detected beam interactions.Included are such important interactions as atomic collisions, Rutherford backscattering, ion channeling, diffraction, photon absorption, radiative and nonradiative transitions, and nuclear reactions. A variety of analytical and scanning probe microscopy techniques are presented in detail. 352 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book offers a welcome expansion on key concepts, terms, and issues in causality. It brings much needed clarity to psychological injury assessments and the legal contexts that employ them.Focusing on PTSD, traumatic brain injury, and chronic pain (and grounding readers in salient U.S. and Canadian case law), the book sets out a multifactorial causality framework to facilitate admissibility of psychological evidence in court. 660 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is the first graduate-level textbook presenting a comprehensive treatment of Data Converters. It provides comprehensive definition of the parameters used to specify data converters, and covers all the architectures used in Nyquist-rate data converters. The book uses Simulink and Matlab extensively in examples and problem sets. This is a textbook that is also essential for engineering professionals as it was written in response to a shortage of organically organized material on the topic. The book assumes a solid background in analog and digital circuits as well as a working knowledge of simulation tools for circuit and behavioral analysis. 460 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Modern science and technology, from materials science to integrated circuit development, is directed toward the nanoscale. From thin films to field effect transistors, the emphasis is on reducing dimensions from the micro to the nanoscale. Fundamentals of Nanoscale Film Analysis concentrates on analysis of the structure and composition of the surface and the outer few tens to hundred nanometers in depth. It describes characterization techniques to quantify the structure, composition and depth distribution of materials with the use of energetic particles and photons.The book describes the fundamentals of materials characterization from the standpoint of the incident photons or particles which interrogate nanoscale structures. These induced reactions lead to the emission of a variety of detected of particles and photons. It is the energy and intensity of the detected beams that is the basis of the characterization of the materials. The array of experimental techniques used in nanoscale materials analysis covers a wide range of incident particle and detected beam interactions.Included are such important interactions as atomic collisions, Rutherford backscattering, ion channeling, diffraction, photon absorption, radiative and nonradiative transitions, and nuclear reactions. A variety of analytical and scanning probe microscopy techniques are presented in detail.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 352 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases as well as for the progress on the development of prophylactic and therapeutic vaccines. This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It has recently been clarified that DCs are important targets and reservoirs of HIV and may play an important role in virus spreading to T cells. Interestingly, HIV can exploit many of the cellular processes responsible for the generation and regulation of the adaptive immune responses to gain access to its main target cells, i.e. the CD4+ T lymphocytes. Thus, the central role of DCs in stimulating T cell activation not only provides a route for viral transmission, but also represents a vulnerable point at which HIV-1 can interfere with the initiation of primary T cell immunity.Recent studies have revealed that several HIV proteins can profoundly influence the phenotype and functions of DCs even in the absence of a productive infection, often resulting in an abnormal immune response. While this knowledge has resulted in the identification of some major mechanisms involved in the pathogenesis of HIV-1 infection, the recent progress on DC biology has opened perspectives in the research on new adjuvants (selectively acting on DCs) and on novel strategies for the in vivo targeting of antigens to DCs, which appear to be highly relevant for the development of HIV vaccines. Of note, defects in the number and functions of DCs have been observed in the course of HIV infection and during disease progression, thus suggesting that DCs play an important role in the immune control of viral replication and virus-induced dysfunctions. The development of therapeutic vaccination strategies to be combined with HAART is thought as an important step for an effective control of HIV infection in patients. In this context, the use of autologous DCs may represent an attracting strategy. Notably, DCs are now regarded as a valuable approach for the development of cancer vaccines and several clinical trials have explored the efficacy of different DC preparations as cellular adjuvants in inducing a potentially protective immune response. Recent data in animal models provide the background for the clinical testing of DC-based vaccines in HIV-1-infected patients. Now that we start to understand the complex interactions between HIV and DCs in the pathogenesis of AIDS and we are learning how to prepare potentially effective DCs from lessons on cancer vaccines, we may reasonably assume that DC-based therapeutic vaccines can represent a topic of increasing interest in protocols of clinical immunotherapy of HIV-1-infected patients. 576 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body. 448 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases as well as for the progress on the development of prophylactic and therapeutic vaccines.This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It has recently been clarified that DCs are important targets and reservoirs of HIV and may play an important role in virus spreading to T cells. Interestingly, HIV can exploit many of the cellular processes responsible for the generation and regulation of the adaptive immune responses to gain access to its main target cells, i.e. the CD4+ T lymphocytes. Thus, the central role of DCs in stimulating T cell activation not only provides a route for viral transmission, but also represents a vulnerable point at which HIV-1 can interfere with the initiation of primary T cell immunity.Recent studies have revealed that several HIV proteins can profoundly influence the phenotype and functions of DCs even in the absence of a productive infection, often resulting in an abnormal immune response. While this knowledge has resulted in the identification of some major mechanisms involved in the pathogenesis of HIV-1 infection, the recent progress on DC biology has opened perspectives in the research on new adjuvants (selectively acting on DCs) and on novel strategies for the in vivo targeting of antigens to DCs, which appear to be highly relevant for the development of HIV vaccines. Of note, defects in the number and functions of DCs have been observed in the course of HIV infection and during disease progression, thus suggesting that DCs play an important role in the immune control of viral replication and virus-induced dysfunctions. The development of therapeutic vaccination strategies to be combined with HAART is thought as an important step for an effective control of HIV infection in patients. In this context, the use of autologous DCs may represent an attracting strategy. Notably, DCs are now regarded as a valuable approach for the development of cancer vaccines and several clinical trials have explored the efficacy of different DC preparations as cellular adjuvants in inducing a potentially protective immune response. Recent data in animal models provide the background for the clinical testing of DC-based vaccines in HIV-1-infected patients. Now that we start to understand the complex interactions between HIV and DCs in the pathogenesis of AIDS and we are learning how to prepare potentially effective DCs from lessons on cancer vaccines, we may reasonably assume that DC-based therapeutic vaccines can represent a topic of increasing interest in protocols of clinical immunotherapy of HIV-1-infected patients.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 576 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It is well known, that the Sun as central star of our solar system gravitationally controls the orbits of planets and minor bodies. Much less known is the domain of plasma fields and charged particles, however, in which the Sun with a radius of less than 0.7 Million km governs the heliosphere out to about 15 Billion km, a distance about 20 000 times larger in radius or nearly 1013 times bigger in volume. What forces activates the Sun to maintain this power Coronal Mass Ejections (CMEs) and their descendants are the troops serving the Sun during high solar activity periods.This volume offers a comprehensive and integrated overview of our present knowledge and understanding of Coronal Mass Ejections (CMEs) and their descendants, Interplanetary CMEs (ICMEs). It results from a series of workshops held between 2000 and 2004. An international team of about sixty experimenters involved e.g. in the SOHO, ULYSSES, VOYAGER, PIONEER, HELIOS, WIND, IMP, and ACE missions, ground observers, and theoreticians worked jointly on interpreting the observations and developing new models for CME initiations, development, and interplanetary propagation.The book is intended to provide scientists active in space physics research a with an up-to-date status of the current understanding of CMEs and ICMEs and their effects in the heliosphere, and also to serve the advanced graduate student with introductory material on this active field of research.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 492 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Our understanding of the biology of papillomaviruses has increased dramatically over the past 25 years. Before then, the lack of a facile tissue culture system had left this virus family behind the other ¿DNA tumor viruses,¿ such as SV40 and murine polyomavirus. However, with the advent of molecular cloning and other new techniques, coupled with the pivotal stimulus given by connecting HPV infection and cervical cancer, the field has flourished. This progress has culminated in the development of the first true anticancer vaccine, using vir- like particles of the HPV16 and 18 capsid proteins. All investigators in the field should take pride in their contribution to a wonderful scientific journey with such a spectacular humanitarian outcome. Their basic studies, technological innovations, and clinical investigation serve as a model of the positive impact of science in society. The obvious difficulty in assembling a book about any rapidly moving sci- tific field is that many observations may be out of date by the time of publication. Given the rate of progress in papillomavirus research, this text may suffer in this regard. However, the release of the HPV vaccine completes a major era, which should be marked by a summary of the work to date. In this summary, we have emphasized the biology of papillomaviruses as well as their clinical importance. Many of the lessons learned have obvious relevance to other viruses and cancers, and they illuminate new pathways to oncogenesis. These lessons stand alongside the vaccine as monuments of progress.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Spectroscopic methods are not only important as an analytical tool, they also provide information about fundamental physical and chemical properties of molecules, the molecular and electronic structure, and the dynamic behaviour of molecules. Starting from a comprehensive quantum mechanical description, ESR Spectroscopy in Membrane Biophysics introduces the optical (IR, Raman, UV/Vis, CD, fluorescence and laser spectroscopy) and magnetic resonance (1D and 2D-NMR, ESR) techniques. ESR Spectroscopy in Membrane Biophysics is a timely review of the increasing interest in using spin-label ESR as an alternative structural technique for NMR or X-ray diffraction. It is aimed at training an audience to learn ESR spectroscopy to determine membrane protein structures, conformational dynamics and protein-lipid interaction. 341 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity. 208 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders. 580 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 580 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This two volume handbook provides a comprehensive examination of policy, practice, research and theory related to English Language Teaching in international contexts. More than 70 chapters highlight the research foundation for best practices, frameworks for policy decisions, and areas of consensus and controversy in second language acquisition and pedagogy. The Handbook provides a unique resource for policy makers, educational administrators, and researchers concerned with meeting the increasing demand for effective English language teaching. It offers a strongly socio-cultural view of language learning and teaching. It is comprehensive and global in perspective with a range of fresh new voices in English language teaching research. 1268 pp. Englisch.