springer us okt 1991 (35 risultati)

Buch. Condizione: Neu. Neuware - Proceedings of the 1990 Conference on the Southwest Economy Sponsored by the Federal Reserve Bank of Dallas.

Buch. Condizione: Neu. Neuware - Although research in architectural synthesis has been conducted for over ten years it has had very little impact on industry. This in our view is due to the inability of current architectural synthesizers to provide area-delay competitive (or 'optimal') architectures, that will support interfaces to analog, asynchronous, and other complex processes. They also fail to incorporate testability. The OASIC (optimal architectural synthesis with interface constraints) architectural synthesizer and the CATREE (computer aided trees) synthesizer demonstrate how these problems can be solved. Traditionally architectural synthesis is viewed as NP hard and there fore most research has involved heuristics. OASIC demonstrates by using an IP approach (using polyhedral analysis), that most input algo rithms can be synthesized very fast into globally optimal architectures. Since a mathematical model is used, complex interface constraints can easily be incorporated and solved. Research in test incorporation has in general been separate from syn thesis research. This is due to the fact that traditional test research has been at the gate or lower level of design representation. Nevertheless as technologies scale down, and complexity of design scales up, the push for reducing testing times is increased. On way to deal with this is to incorporate test strategies early in the design process. The second half of this text examines an approach for integrating architectural synthesis with test incorporation. Research showed that test must be considered during synthesis to provide good architectural solutions which minimize Xlll area delay cost functions.

Buch. Condizione: Neu. Neuware - Oceanic basalts are the most abundant rock type found at the earth's surface, and as such they have been the subject of considerable research, particularly since the concept of sea-floor spreading became widely accepted. This book provides a review of these rocks, first dicussing how we sample the ocean floor and what we know about the structure of the oceanic crust, followed by an overview of the various regional settings (Pacific crust, Atlantic crust, marginal basins, seamounts and islands) and finally examines the main processes (and their interactions) which prevail during the generation and emplacement of oceanic basalt magmas. This is a volume for geologists, geochemists and geophysicists and a source of reference for advanced undergraduate students and postgraduates in these disciplines.

Buch. Condizione: Neu. Neuware - Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Plastics are part of everyday life and contribute immensely to the benefit of humanity. When failures occur, they are due in part either to inferior properties (resulting from poor design or badly controlled processing), or to an incomplete understanding of the properties and applications of plastics materials. Since publication of the first edition, the plastics industry has increas ingly adopted advanced business procedures and automation (such as closed loop control and robotics), to combat the effects of recession, and has moved increasingly towards methods based on sound scientific and technological principles. Plastics have increasingly been used in appli cations once dominated by the use of metals and ceramics. For instance, in the automotive industry, the modern car now contains a much higher proportion of polymers, including commodity plastics and more spec ialized materials. In addition, compact discs are being made from new injection-moulding grades of polycarbonate, which meet the requirements of a demanding process. This second edition has been thoroughly revised and extended to include new materials, technologies and design concepts. Chapters on thermoplastics reflect the development of polymer blends and alloys, whilst the chapters devoted to thermosets have been reorganized to accommodate the renaissance in the applications of phenolics and to cover the growing importance of polyurethanes. The related two component process technologies are now included; having undergone major developments in the last decade, they have become important shaping processes. 212 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -SOME DISCLAIMERS It is somewhat unusual to begin a book by declaring what it is not, but the topic of police behavior is so complex that it requires the writer to state as early as possible the limits of what he has written here to describe and explain a police officer's experience. In order for the reader to get a clear idea of what areas of police behavior are to be described, it is nec essary to delineate those aspects of police behavior that are beyond the scope of this book. First of all, this book is about the psychological effects of police work on policemen: male police officers. Nearly all of the police officers with whom I have worked have been men, so my impressions and opinions are based on the experiences of male police officers. Consequently, descriptions and expla nations of the motivations, anxieties, psychological defenses, and resultant behavior of police officers must be limited to policemen. I believe that there are significant differences in the psychological effects of police work on men and women, but this book does not address this issue. 244 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In recent years, the boundaries of the neurological fields have blurred, and students and scientists in all subdivisions of neuroscience now must be familiar not only with the terminology of their own specialty but also with that of the related disciplines. In response to these developments, the author has written this revised and expanded edition of her Desk Reference for Neuroanatomy (Springer-Verlag 1977), entitled Desk Reference for Neuroscience, Second Edition. The dictionary has been amplified to include terms from neurophysiology, neuropathology, and neuropharmacology, in addition to neuroanatomy. Illustrations have been added and the references and bibliographythoroughly updated. Students and scientists will find the second edition of the Desk Reference for Neuroscience an accessible and practical guide to essential terms and definitions in all branches of the neurosciences.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -SOME DISCLAIMERS It is somewhat unusual to begin a book by declaring what it is not, but the topic of police behavior is so complex that it requires the writer to state as early as possible the limits of what he has written here to describe and explain a police officer's experience. In order for the reader to get a clear idea of what areas of police behavior are to be described, it is nec essary to delineate those aspects of police behavior that are beyond the scope of this book. First of all, this book is about the psychological effects of police work on policemen: male police officers. Nearly all of the police officers with whom I have worked have been men, so my impressions and opinions are based on the experiences of male police officers. Consequently, descriptions and expla nations of the motivations, anxieties, psychological defenses, and resultant behavior of police officers must be limited to policemen. I believe that there are significant differences in the psychological effects of police work on men and women, but this book does not address this issue.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For many years, the dominant fault model in automatic test pattern gen eration (ATPG) for digital integrated circuits has been the stuck-at fault model. The static nature of stuck-at fault testing when compared to the extremely dynamic nature of integrated circuit (IC) technology has caused many to question whether or not stuck-at fault based testing is still viable. Attempts at answering this question have not been wholly satisfying due to a lack of true quantification, statistical significance, and/or high computational expense. In this monograph we introduce a methodology to address the ques tion in a manner which circumvents the drawbacks of previous approaches. The method is based on symbolic Boolean functional analyses using Or dered Binary Decision Diagrams (OBDDs). OBDDs have been conjectured to be an attractive representation form for Boolean functions, although cases ex ist for which their complexity is guaranteed to grow exponentially with input cardinality. Classes of Boolean functions which exploit the efficiencies inherent in OBDDs to a very great extent are examined in Chapter 7. Exact equa tions giving their OBDD sizes are derived, whereas until very recently only size bounds have been available. These size equations suggest that straight forward applications of OBDDs to design and test related problems may not prove as fruitful as was once thought. 156 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents. An emerging powerful tool of molecular pharmacology is described by Holcenberg and Wu. Manipulation of genetic expression by modification of messenger RNA is now within our reach, and the basic concepts are suc cinctly reviewed as a primer on future biochemical engineering of new anti cancer molecules. Another concept that appears to be worthy of further study in both experimental and clinical chemotherapy concerns obs'ervations on the modulation of activity by the nucleoside transport inhibitor, dipyri damole. How potentiation of several anticancer drugs occurs has practical, as well as theoretical, ramifications, discussed by Goel and HowelL Finally, O'Dwyer and La Creta present a fresh look at sensitization of chemotherapy by the hypoxic radiosensitizer, SR-2731. 184 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -After alm ost three scores of years of basic and applied research, the field of speech processing is, at present, undergoing a rapid growth in terms of both performance and applications and this is fueHed by the advances being made in the areas of microelectronics, computation and algorithm design.Speech processing relates to three aspects of voice communications: -Speech Coding and transmission which is mainly concerned with man-to man voice communication. -Speech Synthesis which deals with machine-to-man communication. -Speech Recognition which is related to man-to-machine communication. Widespread application and use of low-bit rate voice codec., synthesizers and recognizers which are all speech processing products requires ideaHy internationally accepted quality assessment and evaluation methods as weH as speech processing standards so that they may be interconnected and used independently of their designers and manufacturers without costly interfaces. This book presents, in a tutorial manner, both fundamental and applied aspects of the above topics which have been prepared by weH-known specialists in their respective areas. The book is based on lectures which were sponsored by AGARD/NATO and delivered by the authors, in several NATO countries, to audiences consisting mainly of academic and industrial R&D engineers and physicists as weH as civil and military C3I systems planners and designers. 260 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During a meeting in Toronto last winter, Mike Jenkins, Bob Bernecky and I were discussing how the two existing theories on arrays influenced or were in fluenced by programming languages and systems. More's Army Theory was the basis for NIAL and APL2 and Mullin's A Mathematics of A rmys(MOA) , is being used as an algebra of arrays in functional and A-calculus based pro gramming languages. MOA was influenced by Iverson's initial and extended algebra, the foundations for APL and J respectively. We discussed that there is a lot of interest in the Computer Science and Engineering communities concerning formal methods for languages that could support massively parallel operations in scientific computing, a back to-roots interest for both Mike and myself. Languages for this domain can no longer be informally developed since it is necessary to map languages easily to many multiprocessor architectures. Software systems intended for parallel computation require a formal basis so that modifications can be done with relative ease while ensuring integrity in design. List based lan guages are profiting from theoretical foundations such as the Bird-Meertens formalism. Their theory has been successfully used to describe list based parallel algorithms across many classes of architectures. 336 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The chapters in this collection are from papers which were presented at a symposium on solid-state NMR of polymers. A two-part program on available NMR techniques applicable to solid polymer analysis was presented at the 3rd Chemical Congress of North American held in Toronto, Ontario, June 5-10,1988. The program was sponsored by the Division of Polymer Chemistry with support provided by the Division, its Industrial Sponsors, and the Donors of the Petroleum Research Fund administered by the American Chemical Society. Co-organizers included Professor Colin Fyfe of the University of British Columbia (Vancouver, Canada), Professor Hans Spiess of the Max Planck Institut fur Polymerforschung (Mainz, West Germany), and myself. The full-day tutorial, which was free to registered attendees, covered the range of topics. The purpose of the tutorial was to provide a basic introduction to the field so that newcomers to its present and future applications could develop sufficient understanding to learn effectively from the subsequent symposium. The first talk attempted to give listeners a feel for the way a novice spectroscopist can learn to use the various NMR techniques to explore his own areas of interest. Simple experiments can provide unique information about solid polymers that can be useful in interpreting synthetic results and in relating solid-state conformation, morphology and molecular motion to physical properties. 424 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The workshop 'Biologically Inspired Physics' was organized, with the support of the NATO Scientific Affairs Division and the Directorate-General for Science, Research and Development of the Commission of the European Communities, in order to review some subjects of physics of condensed matter which are inspired by biological problems or deal with biological systems, but which address physical questions. The main topics discussed in the meeting were: 1. Macromolecules: In particular, proteins and nucleic acids. Special emphasis was placed on modelling protein folding, where analogies with disordered systems in con densed matter (glasses, spin glasses) were suggested. It is not clear at this point whether such analogies will help in solving the folding problem. Interesting problems in nucleic acids (in particular DNA) deal with the dynamics of semiflexible chains with torsion and the relationship between topology and local structure. They arise from such biological problems as DNA packing or supercoiling. 2. Membranes: This field has witnessed recent progress in the understanding of the statistical mechanics of fluctuating flexible sheets, such as lipid bilayers. It appears that one is close to understanding shape fluctuations in red blood cells on a molec ular basis. Open problems arise from phenomena such as budding or membrane fusion. Experiments on model systems, such as vesicle systems or artificial lipids, have great potential. Phenomena occurring inside the membrane (protein diffusion, ionic pumps) were only discussed briefly. 412 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The development of chemicals to selectively control the growth of weeds has been a fascinating success story which has unfolded largely during the last four decades. The dramatic growth of herbicide research that followed the wartime discoveries of the auxin-type herbicides (phenoxyalkanoic acids) resulted in a whole range of compounds and mixtures which are used to eliminate broad-or narrow-leaved weeds from agricultural, horticul tural, or forestry crops. Today, the safe use of this armament of compounds requires our understanding of their mode of action, metabolism, and environmental persistence. The most recently developed herbicides are highly effective inhibitors of specific enzyme systems, and formulation may be an important factor determining their efficient delivery at specific target sites. In this book, the major target sites of herbicide action are discussed in Chapters 1-5, with particular reference to photosynthesis; amino acid, lipid, and carotenoid synthesis; and other primary target sites. The effects of synergists or antagonists as modifiers of herbicide action are described in Chapter 6. The importance of efficient target site delivery as a fundamental factor in herbicide activity and selectivity is generally recognized. Delivery of a potentially lethal dose of active ingredient may depend on a whole range of factors including the efficiency of application, retention, absorption, translocation, immobilization, and detoxification. These aspects are con sidered in the remaining chapters, with particular reference to the pathways and mechanisms involved in the uptake, translocation, and metabolism of soil-and foliage-applied herbicides. 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents an approach to quantifying consciousness and its various states. It represents over ten years of work in developing, test ing, and researching the use of relatively simple self-report question naires in the retrospective assessment of subjective or phenomenologi cal experience. While the simplicity of the method allows for subjective experience to be reliably and validly assessed across various short stim ulus conditions, the flexibility of the approach allows the cognitive psy chologist, consciousness researcher, and mental health professional to quantify and statistically assess the phenomenological variables associ ated with various stimulus conditions, altered-state induction tech niques, and clinical procedures. The methodology allows the cognitive psychologist and mental health professional to comprehensively quantify the structures and pat terns of subjective experience dealing with imagery, attention, affect, volitional control, internal dialogue, and so forth to determine how these phenomenological structures might covary during such stimulus conditions as free association, a sexual fantasy, creative problem solving, or a panic attack. It allows for various phenomenological pro cesses to be reported, quantified, and statistically assessed in a rather comprehensive fashion that should help shed greater understanding on the nature of mind or consciousness. 450 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The layout of an integrated circuit (lC) is the process of assigning geometric shape, size and position to the components (transistors and connections) used in its fabrication. Since the number of components in modem ICs is enormous, computer aided-design (CAD) programs are required to automate the difficult layout process. Prior CAD methods are inexact or limited in scope, and produce layouts whose area, and consequently manufacturing costs, are larger than necessary. This book addresses the problem of minimizing exactly the layout area of an important class of basic IC structures called CMOS cells. First, we precisely define the possible goals in area minimization for such cells, namely width and height minimization, with allowance for area-reducing reordering of transistors. We reformulate the layout problem in terms of a graph model and develop new graph-theoretic concepts that completely characterize the fundamental area minimization problems for series-parallel and nonseries-parallel circuits. These concepts lead to practical algorithms that solve all the basic layout minimization problems exactly, both for a single cell and for a one-dimensional array of such cells. Although a few of these layout problems have been solved or partially solved previously, we present here the first complete solutions to all the problems of interest. 188 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book really began in 1980 with our first microcomputer, an Apple II +. The great value of the Apple II + was that we could take the computer programs we had been building on mainframe and mini-computers, and make them available to the many fisheries biologists who also had Apple II + 's. About 6 months after we got our first Apple, John Glaister came through Vancouver and saw what we were doing and realized that his agency (New South Wales State Fisheries) had the same equipment and could run the same programs. John organized a training course in Australia where we showed about 25 Australian fisheries biologists how to use microcomputers to do many standard fisheries analyses. In the process of organizing this and sub sequent courses we developed a series of lecture notes. Over the last 10 years these notes have evolved into the chapters of this book. 592 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book has a rather strange history. It began in Spring 1989, thirteen years after our Systems Science Department at SUNY -Binghamton was established, when I was asked by a group of students in our doctoral program to have a meeting with them. The spokesman of the group, Cliff Joslyn, opened our meeting by stating its purpose. I can closely paraphrase what he said: 'We called this meeting to discuss with you, as Chairman of the Department, a fundamental problem with our systems science curriculum. In general, we consider it a good curriculum: we learn a lot of concepts, principles, and methodological tools, mathematical, computational, heuristic, which are fundamental to understanding and dealing with systems. And, yet, we learn virtually nothing about systems science itself. What is systems science What are its historical roots What are its aims Where does it stand and where is it likely to go These are pressing questions to us. After all, aren't we supposed to carry the systems science flag after we graduate from this program We feel that a broad introductory course to systems science is urgently needed in the curriculum. Do you agree with this assessment ' The answer was obvious and, yet, not easy to give: 'I agree, of course, but I do not see how the situation could be alleviated in the foreseeable future. 684 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The development of chemicals to selectively control the growth of weeds has been a fascinating success story which has unfolded largely during the last four decades. The dramatic growth of herbicide research that followed the wartime discoveries of the auxin-type herbicides (phenoxyalkanoic acids) resulted in a whole range of compounds and mixtures which are used to eliminate broad-or narrow-leaved weeds from agricultural, horticul tural, or forestry crops. Today, the safe use of this armament of compounds requires our understanding of their mode of action, metabolism, and environmental persistence. The most recently developed herbicides are highly effective inhibitors of specific enzyme systems, and formulation may be an important factor determining their efficient delivery at specific target sites. In this book, the major target sites of herbicide action are discussed in Chapters 1-5, with particular reference to photosynthesis; amino acid, lipid, and carotenoid synthesis; and other primary target sites. The effects of synergists or antagonists as modifiers of herbicide action are described in Chapter 6. The importance of efficient target site delivery as a fundamental factor in herbicide activity and selectivity is generally recognized. Delivery of a potentially lethal dose of active ingredient may depend on a whole range of factors including the efficiency of application, retention, absorption, translocation, immobilization, and detoxification. These aspects are con sidered in the remaining chapters, with particular reference to the pathways and mechanisms involved in the uptake, translocation, and metabolism of soil-and foliage-applied herbicides.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 360 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The workshop 'Biologically Inspired Physics' was organized, with the support of the NATO Scientific Affairs Division and the Directorate-General for Science, Research and Development of the Commission of the European Communities, in order to review some subjects of physics of condensed matter which are inspired by biological problems or deal with biological systems, but which address physical questions. The main topics discussed in the meeting were: 1. Macromolecules: In particular, proteins and nucleic acids. Special emphasis was placed on modelling protein folding, where analogies with disordered systems in con densed matter (glasses, spin glasses) were suggested. It is not clear at this point whether such analogies will help in solving the folding problem. Interesting problems in nucleic acids (in particular DNA) deal with the dynamics of semiflexible chains with torsion and the relationship between topology and local structure. They arise from such biological problems as DNA packing or supercoiling. 2. Membranes: This field has witnessed recent progress in the understanding of the statistical mechanics of fluctuating flexible sheets, such as lipid bilayers. It appears that one is close to understanding shape fluctuations in red blood cells on a molec ular basis. Open problems arise from phenomena such as budding or membrane fusion. Experiments on model systems, such as vesicle systems or artificial lipids, have great potential. Phenomena occurring inside the membrane (protein diffusion, ionic pumps) were only discussed briefly.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 412 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -rlevel to the networklevel. Inaddition, thirty six posters were accepted forpresentation.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 432 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents. An emerging powerful tool of molecular pharmacology is described by Holcenberg and Wu. Manipulation of genetic expression by modification of messenger RNA is now within our reach, and the basic concepts are suc cinctly reviewed as a primer on future biochemical engineering of new anti cancer molecules. Another concept that appears to be worthy of further study in both experimental and clinical chemotherapy concerns obs'ervations on the modulation of activity by the nucleoside transport inhibitor, dipyri damole. How potentiation of several anticancer drugs occurs has practical, as well as theoretical, ramifications, discussed by Goel and HowelL Finally, O'Dwyer and La Creta present a fresh look at sensitization of chemotherapy by the hypoxic radiosensitizer, SR-2731.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The chapters in this collection are from papers which were presented at a symposium on solid-state NMR of polymers. A two-part program on available NMR techniques applicable to solid polymer analysis was presented at the 3rd Chemical Congress of North American held in Toronto, Ontario, June 5-10,1988. The program was sponsored by the Division of Polymer Chemistry with support provided by the Division, its Industrial Sponsors, and the Donors of the Petroleum Research Fund administered by the American Chemical Society. Co-organizers included Professor Colin Fyfe of the University of British Columbia (Vancouver, Canada), Professor Hans Spiess of the Max Planck Institut fur Polymerforschung (Mainz, West Germany), and myself. The full-day tutorial, which was free to registered attendees, covered the range of topics. The purpose of the tutorial was to provide a basic introduction to the field so that newcomers to its present and future applications could develop sufficient understanding to learn effectively from the subsequent symposium. The first talk attempted to give listeners a feel for the way a novice spectroscopist can learn to use the various NMR techniques to explore his own areas of interest. Simple experiments can provide unique information about solid polymers that can be useful in interpreting synthetic results and in relating solid-state conformation, morphology and molecular motion to physical properties.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 424 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -During May 21-June 1 1990, the eleventh course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the Italian Ministry of Universities and of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and Technobiochip. The subject of the course was 'Molecular Basis of Human Cancer' with participants selected worldwide from 15 different countries. The purpose of the course was to address, in a tutorial and structural fashion, the molecular basis of human cancer, including the mechanism of signal transduction in mammalian cells, the genetic mechanism of malignant transformation in man, growth factors, hormone receptors, cell membrane and cytoskeleton, and DNA high order structure. The course had this as its major objective and the resulting book reflects it. The participants were exposed to a critical evaluation of current knowledge about cancer and to some of the key problems that remain as stumbling blocks to our eventual understanding of this important biological and medical problem. Through the media of formal and informal lectures, workshops, symposia and informal discussions, a select group of interested young and senior scientists were acquainted with many of the aspects of human cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book presents an approach to quantifying consciousness and its various states. It represents over ten years of work in developing, test ing, and researching the use of relatively simple self-report question naires in the retrospective assessment of subjective or phenomenologi cal experience. While the simplicity of the method allows for subjective experience to be reliably and validly assessed across various short stim ulus conditions, the flexibility of the approach allows the cognitive psy chologist, consciousness researcher, and mental health professional to quantify and statistically assess the phenomenological variables associ ated with various stimulus conditions, altered-state induction tech niques, and clinical procedures. The methodology allows the cognitive psychologist and mental health professional to comprehensively quantify the structures and pat terns of subjective experience dealing with imagery, attention, affect, volitional control, internal dialogue, and so forth to determine how these phenomenological structures might covary during such stimulus conditions as free association, a sexual fantasy, creative problem solving, or a panic attack. It allows for various phenomenological pro cesses to be reported, quantified, and statistically assessed in a rather comprehensive fashion that should help shed greater understanding on the nature of mind or consciousness.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 450 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The recentexplosionofactivity inneural modelingseemsto have beendriven more by advances inthe theories and applicationsoflearning paradigms for artificial neural networks than by advances in our knowledge of real nervous systems. In the past few years, major conferences on neural networks and neural modeling have emerged and, appropriately, have focussed on technological exploitation of these advances. Sensingthat the recentleaps in both computational powerand knowledge ofthe nervous system may have setthe stage for a revolution intheoretical neurobiology, neuroscientists have welcomed thenew neural modeling; butmanyofthem would like tosee itdirected as heavily toward understanding of the nervou$ system as it is presently directed toward computertechnology and control-system engineering. Furthermore, some neuroscientists believe thattechnologists shouldnotbe satisfiedonly with exploiting or extending the recent advances in learning paradigms, that emerging knowledge about real nervous systems will suggest other, comparably valuable, paradigms forsignal processingand control. Ourmotive as organizers was to have a conference that focussed on both of these areas -- emerging modeling tools and concepts for neurobiologists, and emerging neurobiological concepts and neurobiological knowledge ofpotential use to technologists. Ourprinciple ofdesign was simple. We attempted to organize aconference withagroup ofspeakers that would be most illuminating and exciting to us and to our students. We succeeded. EdwinR. Lewis INTRODUCTION This volume contains the collected papers of the 1990 Conference on Analysis and ModelingofNeural Systems, held July 25-27, in Berkeley, California. There were 21 invited talks at the meeting, covering aspects ofanalysis and modeling from the subcellularlevel to the networklevel. Inaddition, thirty six posters were accepted forpresentation. 432 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book benefited from the financial support of a French Government scholarship between 1976 and 1978. It sponsored a doctoral thesis in which initial theoretical, empirical, and historical reflections on acci dents were developed and written while I was a student at the Ecole des Hautes Etudes en Sciences Sociales in Paris. The New Zealand Depart ment of Labour funded a study on industrial accidents and night work during 1979-80. In 1982-83, the award of a postdoctoral fellowship by the University of Canterbury (New Zealand) permitted a first version of this book to be finished. In the summer of 1986-87 the Funda~ao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) and the Labora toire d'Ergonomie et de Neurophysiologie du Travail of the Centre Na tional des Arts et Metiers joined forces to fund a stay in Paris where the second draft of this book was presented in a special doctoral seminar series. The third draft was completed during a 1988 research leave granted by the Conjunto de Ciencia Politica of the Universidade Es tadual de Campinas (UNICAMP). On a further research leave from the same unit, and thanks to a postdoctoral fellowship from the Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnol6gico (CNPq), final redrafting was carried out between August and October 1990 when I was a visiting fellow in the Science, Technology, and Society Program at Cornell University. I am deeply grateful to these institutions for their generosity. 340 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book really began in 1980 with our first microcomputer, an Apple II +. The great value of the Apple II + was that we could take the computer programs we had been building on mainframe and mini-computers, and make them available to the many fisheries biologists who also had Apple II + 's. About 6 months after we got our first Apple, John Glaister came through Vancouver and saw what we were doing and realized that his agency (New South Wales State Fisheries) had the same equipment and could run the same programs. John organized a training course in Australia where we showed about 25 Australian fisheries biologists how to use microcomputers to do many standard fisheries analyses. In the process of organizing this and sub sequent courses we developed a series of lecture notes. Over the last 10 years these notes have evolved into the chapters of this book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 592 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -HISTORICAL BACKGROUND The use of genetic animal models in neuroscience and biomedical research is showing dramatic growth. The earliest application of these models to research on drug mechanisms was in the area of alcohol research. Mardones (1951) reported successful selective breeding of rats preferring and not preferring to drink alcohol under various conditions of dietary deficiency, suggesting genetic control of alcohol drinking. McClearn and Rodgers (1959, 1961) described differences among inbred mouse strains in preference for 10Ofo ethanol solutions versus tap water. Active exploration of this phenomenon continued until the early 1970s, eventually spawning the entire range of alcohol genetic research reviewed in Chapters 2 and 3 of this volume. Notably, oral alcohol self-administration has served as the basis for the development of several rat lines bred for preference or aversion, and these lines are very actively being investigated. The pioneering research of Dr. McClearn and others was very wide ranging in its conceptual scope and at least touched on all issues currently under intense investigation. The basic approach was to identify high and low preferrers among inbred strains of mice and to search for preference correlates in other traits. One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization. Reviews of these studies concluded that nutritional factors could not completely explain preference differences (Rod gers, 1966; McClearn, 1968). 404 pp. Englisch.