9781586037031 - virtual admet assessment in target selection and maturation: v. 6 (4 risultati)
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Da: Antiquariat Thomas Haker GmbH & Co. KG, Berlin, GermaniaAntiquariat Thomas Haker GmbH & Co. KG
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Hardcover. Condizione: Wie neu. 1st ed. 268 S. Like new. Shrink wrapped. Sprache: Englisch Gewicht in Gramm: 825.
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Da: Revaluation Books, Exeter, Regno UnitoRevaluation Books
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Hardcover. Condizione: Brand New. 1st edition. 255 pages. 9.25x6.50x0.75 inches. In Stock.
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Da: preigu, Osnabrück, Germaniapreigu
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EUR 260,05
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Buch. Condizione: Neu. Virtual ADMET Assessment in Target Selection and Maturation | B. Testa (u. a.) | Buch | Englisch | 2006 | IOS Press | EAN 9781586037031 | Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, 36244 Bad Hersfeld, gpsr[at]libri[dot]de | Anbieter: preigu Print on Demand.
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Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH
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Buch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing fact…or to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods have accelerated the process towards drugability of new chemical structures. Another component of the revolution in drug discovery is the replacement of the disease (indication)-based approach by a target-based approach. A better understanding of pathophysiology of diseases and the underlying biological processes of diseases combined with explosive development of genomics and proteomics have been instrumental in the birth of this new paradigm. This volume summarizes discussions of these three aspects of modern drug discovery, i.e. priority for targets, early ADMET assessment, and in silico screening. We trust that readers from academia as well as from industry will benefit from these studies.
