9783527306381 - Protein Synthesis and Ribosome Structure: Translating the Genome (7 risultati)

Hardcover. Condizione: As New. Condizione sovraccoperta: No Dust Jacket. (?); (?). An in-depth and authoritative guide to the molecular machinery of protein synthesis, this volume explores the structure and function of the ribosome in detail. Combining insights from structural biology, genetics, and pharmacology, it offers a comprehensive look at how genetic information is translated into proteins. Ideal for researchers, students, and professionals in molecular biology and biochemistry. ; 18x25x3.9cm; 597 pages.

, Hardcover/Pappeinband. Condizione: Gut. Auflage: 1. Auflage. 597 Seiten Fresh and clean hardcover copy in good condition. Frisches und sauberes Hardcover-Exemplar in gutem Zustand. Contents: Preface XV 1 A History of Protein Biosynthesis and Ribosome Research 1.1 Introduction 1.2 The Archaeology of Protein Synthesis - The 1940s: Forgotten Paradigms 1.3 Basic Mechanisms - The 1950s 1.3.1 Steps toward an in vitro Protein Synthesis System 1.3.2 Amino Acid Activation and the Emergence of Soluble RNA 1.3.3 From Microsomes to Ribosomes 1.3.4 Models 1.4 The Golden Age ofTranslation - The 1960s 1.4.1 From Enzymatic Adaptation to Gene Regulation: Messenger RNA 1.4.2 A Bacterial in vitro System ofProtein Synthesis 1.4.3 The Functional Dissection ofTranslation 1.4.4 The Structural Dissection ofthe Ribosome 1.5 1970-1990s: A Brief Synopsis 2 Structure of the Ribosome - Gregor Bloho 2.1 General Features ofthe Ribosome and Ribosomal Subunits 2.2 A Special Feature ofthe 50S Subunit: The Tunnel 2.3 Features of the Ribosomal Subunits at Atomic Resolution 2.4 The Domain Structure of the Ribosomal Subunits 2.5 Interactions ofRNA with RNA or Struts and Bolts in the 3D Fold ofrRNA: Coaxial Stacking and A-minor Motifs 2.5.1 Coaxial Stacldng 2.5.2 A-minor Motifs 2.5.3 Ribose Zippers and Patches ofA-minor Motifs 2.5.3.1 Canonical Ribose Zipper 2.5.3.2 Single-base Ribose Zipper 7 2.6 Progress and New Developments in Understanding rRNA Structures 2.6.1 K-turn 2.6.2 Lonepair Triloop 2.6 .2 .1 Classification of Lonepair Triloops 2.6 .3 Systemizing Base Pairs 2.6 .4 Systemizing RNA Structural Elements 2.7 RNA-protein Interactions 2.7 .1 Problem of RNA Recognition 2.7.2 Chemistry of RNA-protein Interactions 2.7.3 rRNA-protein Interaction 3 Ribosome Assembly 3.1 Assembly Of The Prokaryotic Ribosome - Knud H. Nierhaus 3.1 .1 Introduction 3.1 .2 Processing of rRNAs 3.1 .3 Precursor Particles and Reconstitution Intermediates 3.1 .4 Assembly-initiator Proteins 3 .1 .5 Proteins Essential for the Early Assembly: The Assembly Gradient 3 .1 .6 Late-assembly Components 3 .1 .7 Proteins Solely Involved in Assembly 3.1 .8 Assembly Maps 3.2 Eukaryotic Ribosome Synthesis - Denis L.J . Lafontaine 3.2.1 Introduction 3.1 .1 Prelude 3 .2 .2 Why so many RRPs? 3.2 .3 (Pre-)ribosome Assembly, the Proteomic Era 3.2 .4 Ribosomal RNA Processing, Getting there 3.2 .5 Ribosomal RNA Modification : A Solved Issue? 3.2 .5 .1 Ribose Methylation, Pseudouridines formation and the snoRNAs 3.2 .5 .2 The Emergence of the snoRNAs 3.2 .5 .3 Non-ribosomal RNA Substrates for the snoRNAs 3 .2 .5 .4 Possible function(s) of RNA modifications 3.2 .5 .5 Base methylation 3.2 .5 .6 U3 snoRNP, the 'SSU Processome', and the Central Pseudoknot 3.2 .6 SnoRNA Synthesis and Intranuclear Trafficking 3.2 .6.1 SnoRNAs Synthesis 3 .2 .6.2 Non-core snoRNP Proteins required for snoRNA Accumulation 3.2 .6 .3 Interactions between Cleavage Factors and Core snoRNP Proteins 3.2 .6 .4 SnoRNAs Trafficking 3.2 .6 .5 CB/NB are Conserved Sites of Small RNP Synthesis 3.2 .7 Ribosome Intranuclear Movements and Ribosome Export 3.2 .8 The Cytoplasmic Phase of Ribosome Maturation 3.2 .9 Regulatory Mechanisms, all along 3.2 .10 And Now . What's Next? 3.2 .11 Epilogue 3.3 .12 Useful WWW links 4 tRNA and Synthetases 4.1 tRNA : Structure and Function - Viter Marqudz and Knud H. Nierhaus 4.1 .1 Introduction 4.1 .2 Secondary Structure 4.1 .3 Tertiary Structure 4.1 .4 tRNA Modifications 4.1 .5 Recognition of tRNA by tRNA synthetase : Identity Elements 4.1 .6 Is the tRNA Cloverleaf Structure a Pre-requisite for the L-shape? 4.1 .7 Other Functions of tRNA outside the Ribosomal Elongation Cycle 4.1 .8 Human Neurodegenerative Disorders Associated with Mitochondrial tRNAs 4.2 Aminoacylations of tRNAs: Record-keepers for the Genetic Code Llu's Ribas de Pouplana and Paul Schimmel 4.2 .1 Introduction 4.2 .2 The Operational RNA Code 4.2 .3 Extant Aminoacyl-tRNA Synthetases 4.2 .4 The Origin of Aminoacyl-tRNA Synthetase Classes: Two Proteins bound to one tRNA 4.2 .5 A Common Genetic Origin for all Aminoacyl-tRNA Synthetases ? 4.2 .5 .1 Evolution of Extant Enzymes prior to LUCA 4.2 .5 .2 Changes in Acceptor Stem Identity Elements Correlate with Changes in the Code 5 rnRNA Decay and RNA-degrading Machines in Prokaryotes and Eukaryotes - Agamemnonf. Carpousis and Marc Dreyfus 5.1 Summary 5.2 Introduction 5.3 mRNA Decay in E. coli 5 .4 mRNA Decay in S. cerevisiae 5.5 A Comparison of mRNA Decay in E. coli and S. cerevisiae 5.6 RNase E Specificity: A Role in Translation Arrest? 5.7 The E. coli RNA degradosome 5.8 The Autoregulation of RNase E and PNPase Synthesis: A Link between Bulk Translation and mRNA Stability 5.9 RNA-degrading Machines in other Organisms 5 .10 DEAD-box ATPases 5 .11 Perspective 6 tRNA Locations on the Ribosome - Knud H . Nierhaus 6.1 tRNAs Move through Functional Sites on the Ribosome 6.2 Visualization of tRNAs on the Ribosome 6.3 tRNA-ribosome Contacts 7 Initiation of Protein Synthesis 7.1 Initiation of Protein Synthesis in Eubacteria - Daniel N . Wilson 7.1 .1 Overview of Initiation in Eubacteria 7.1 .2 Specialized initiation events : translational coupling, 70S initiation and leaderless mRNAs 7.1 .3 Initiation Factor 1 Binds to the Ribosomal A-site 7.1.4 The Domain Structure of Bacterial IF2 7.1 .5 Interaction Partners of IF2 7.1 .6 The Role of the IF2-dependent GTPase Activity 7.1 .7 The Mystery of the I173-binding Site on the 30S Subunit 7.2 Mechanism and Regulation of Protein Synthesis Initiation in Eukaryotes Alan G. Hinnebusch, Thomas E. Dever, and Nahum Sonenberg 7.2 .1 Introduction 7.2 .1 .1 Overview of Translation-initiation Pathways in Eukaryotes and Prokaryotes 7.2 .1 .2 Conservation and diversity of translation-initiation factors among bacteria, archaea and eukaryotes 7.2 .1 .3 Genetic assays for in vivo functions of eIF2 248 7.2 .2 Generation of Free 40S Subunits and 40S Binding of Met-tRNA 7.2 .2 .1 Dissociation of Idle 80S Ribosomes 7.2 .2 .2 Components of the eIF2/GTP/Met-tRNA Ternary Complex 7.2 .2 .3 The GEF eIF2B regulates terna.

Condizione: New. pp. xviii + 579.

Condizione: New. pp. xviii + 579 Illus.

Condizione: New. pp. xviii + 579.

Gebundene Ausgabe. Condizione: Neu. Gebraucht - Sehr gut Mängelexemplar mit leichten Lagerspuren, Sofortversand - Seit 30 Jahren beschäftigt sich Knud Nierhaus mit dem Ribosom. In diesem Band fügt er, unterstützt von erfahrenen Fachleuten aus verschiedenen Disziplinen, die gegenwärtig gesicherten Erkenntnisse über Struktur und Funktion dieses größten in lebenden Zellen existierenden Enzymkomplexes zu einem beeindruckenden Porträt zusammen. Erwogen werden nahezu sämtliche denkbaren Aspekte des Themas, wobei sich Antworten auf manche schon vor Jahrzehnten gestellte Frage ergeben. Ein Muss für Molekularbiologen, Biotechnologen, Pharmakologen und Molekularmediziner!

Hardcover. Condizione: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.