9786139893119 - Divalproex sodium floating microspheres - Design and Quantification di Rajaram, Subashini; Thomas A, Arun Alphons; Murugan, Abirami (6 risultati)

Paperback. Condizione: Brand New. 124 pages. 8.66x5.91x0.28 inches. In Stock.

Taschenbuch. Condizione: Neu. Divalproex sodium floating microspheres - Design and Quantification | Subashini Rajaram (u. a.) | Taschenbuch | 124 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9786139893119 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption. 124 pp. Englisch.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Rajaram SubashiniDr. Subashini Rajaram.,M.Pharm.,Ph.D.,Working as an Associate Professor in the department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Namakkal, Tamilnadu,India,Awarded Ph.D from The Tamilnadu Dr.M.G.R.M.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 124 pp. Englisch.

Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption.